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CuraBone SIGNED

Predictive models and simulations in bone regeneration: a multiscale patient-specific approach

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CuraBone project word cloud

Explore the words cloud of the CuraBone project. It provides you a very rough idea of what is the project "CuraBone" about.

supervision bone establishment surgical bioreactors image existent loads models quantitatively technologies gap rehabilitation requiring microenvironmental relies experiments capacity creation numerical implant implants recovery adaptive expert methodology validate patient exact simulation hence levels scaffold mechanical musculoskeletal health appropriate bones copies nowadays effectiveness regeneration computational validation scales planning platform finite fea made predictive curabone estimate vitro organ optimize corrective orthopaedic quantified injuries treatment algorithms fix custom body model thanks bridge therapies techniques fabricate hospitals cell surgery preoperative consequently integrating reconstruction lacks treatments rigid

Project "CuraBone" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DE ZARAGOZA Organization address address: CALLE PEDRO CERBUNA 12 city: ZARAGOZA postcode: 50009 website: www.unizar.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://curabone.unizar.es/
Total cost	1˙247˙425 €
EC max contribution	1˙247˙425 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-EID
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2021-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DE ZARAGOZA UNIVERSIDAD DE ZARAGOZA Organization address address: CALLE PEDRO CERBUNA 12 city: ZARAGOZA postcode: 50009 website: www.unizar.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (ZARAGOZA)	coordinator	495˙745.00
2	MATERIALISE NV MATERIALISE NV Organization address address: TECHNOLOGIELAAN 15 city: HEVERLEE postcode: 3001 website: www.materialise.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (HEVERLEE)	participant	751˙680.00
3	AALBORG UNIVERSITET AALBORG UNIVERSITET Organization address address: FREDRIK BAJERS VEJ 7K city: AALBORG postcode: 9220 website: www.aau.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AALBORG)	partner	0.00
4	AnyBody Technology A/S AnyBody Technology A/S Organization address address: Niels Jernes Vej 10 city: Aalborg postcode: 9220 website: www.anybodytech.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (Aalborg)	partner	0.00
5	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	partner	0.00
6	LOZANO BLESA HOSPITAL LOZANO BLESA HOSPITAL Organization address address: n.a. city: Zaragoza postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Zaragoza)	partner	0.00
7	MAZ HOSPITAL MAZ HOSPITAL Organization address address: n.a. city: Zaragoza postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (Zaragoza)	partner	0.00
8	RJAH ORTHOPAEDIC HOSPITAL RJAH ORTHOPAEDIC HOSPITAL Organization address address: n.a. city: Oswestry postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Oswestry)	partner	0.00
9	TA INSTRUMENTS TA INSTRUMENTS Organization address address: n.a. city: New Castle postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (New Castle)	partner	0.00

Map

Project objective

Bone injuries represent a high cost for the European health system, requiring corrective surgery to fix the bones. Traditionally, their treatment relies on classical orthopaedic techniques but, nowadays, it is possible to design and fabricate custom-made implants. Thanks to the current advance in image-based technologies, the reconstruction of models that are exact copies of patient specific bones is possible. Thus, this methodology is appropriate for preoperative surgical planning, but currently lacks of a predictive capacity. It presents a low impact for quantitatively determine the effectiveness of different treatments on bone regeneration and, consequently, the patient recovery. CURABONE aims to bridge this gap, integrating and extending numerical simulation technologies based on image analysis to achieve a predictive methodology, to optimize patient-specific treatment of bone injuries and rehabilitation therapies. Therefore, CURABONE will focus on the establishment of a currently non-existent, but essential multi-validation platform at different scale levels for the creation of bone models. At organ level, patient-specific loads will be quantified from image-based analysis and musculoskeletal rigid-body modelling. At implant level, Finite Element analyses (FEA) of bone and implant/scaffold will be evaluated. At cell level, in-vitro experiments will be developed under controlled microenvironmental conditions in bioreactors to estimate the cell response under different mechanical conditions. All this information obtained from validation at different scales will be integrated in a computational model with a predictive capacity. Hence, CURABONE will not only develop patient-specific musculoskeletal modelling based on FEA and bone adaptive algorithms, but will also bring a step-forward to validate these models at different scales together with supervision of different orthopaedic hospitals expert on bone injuries.

Deliverables

List of deliverables.
Integrative computer bone healing framework.	Documents, reports	2019-07-22 16:45:49
Integrative computer degradation algorithm.	Documents, reports	2019-07-22 16:45:47
Integrative computer bone remodelling framework.	Documents, reports	2019-07-22 16:45:49
Loading conditions for the humerus and radius.	Documents, reports	2019-06-27 14:17:43
Mid Term report	Documents, reports	2019-06-27 14:17:43
Loading conditions for the femur and tibia.	Documents, reports	2019-06-27 14:17:43
Progress report	Documents, reports	2019-06-27 14:17:43
Career Development plans & Declarations on conformity	Documents, reports	2019-06-27 14:17:43
Definition of requirements for ESRs recruitment and training	Documents, reports	2019-06-27 14:17:43
CuraBone web site release	Websites, patent fillings, videos etc.	2019-06-27 14:17:43
Data Management Plan	Documents, reports	2019-06-27 14:17:43

Take a look to the deliverables list in detail: detailed list of CuraBone deliverables.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CURABONE" project.

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Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CURABONE" are provided by the European Opendata Portal: CORDIS opendata.