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CarBon SIGNED

Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CarBon project word cloud

Explore the words cloud of the CarBon project. It provides you a very rough idea of what is the project "CarBon" about.

network communication options expertise therapeutic developmental bioreactors impairs societal trained locomotor insufficient consideration esrs models people scientists edge functionalised bone discovery biology train prevent quality cutting character discover biological suffer understand biotechnology treatments computational vitro functioning either companies cell skilled treatment modulated stimulate pathobiology aging elucidate intellectual orchestrated careers foundation property combine defects silico foundations life charitable uniquely stage transition disciplines transitions multifactorial human scientific equipped young combined engineering academic healing dual undesired skills drug population pivotal diseases osteoarthritis tissue vivo leads physical transferable biomaterials 14 carbon cartilage fate drugs

Project "CarBon" data sheet

The following table provides information about the project.

Coordinator	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.carbonresearch.eu
Total cost	3˙607˙596 €
EC max contribution	3˙607˙596 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	coordinator	766˙122.00
2	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	751˙680.00
3	THE ROYAL VETERINARY COLLEGE THE ROYAL VETERINARY COLLEGE Organization address address: ROYAL COLLEGE STREET city: LONDON postcode: NW1 OTU website: www.rvc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	546˙575.00
4	SURGACOLL TECHNOLOGIES LIMITED SURGACOLL TECHNOLOGIES LIMITED Organization address address: INVENT DUBLIN CITY UNIVERSITY GLASNEVIN city: DUBLIN postcode: 9 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	265˙674.00
5	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Organization address address: College Green city: DUBLIN postcode: 2 website: www.tcd.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	participant	265˙674.00
6	IRCCS OSPEDALE POLICLINICO SAN MARTINO IRCCS OSPEDALE POLICLINICO SAN MARTINO Organization address address: LARGO ROSANNA BENZI 10 city: GENOVA postcode: 16132 website: www.hsanmartino.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (GENOVA)	participant	258˙061.00
7	LIFETEC GROUP BV LIFETEC GROUP BV Organization address address: KENNEDYPLEIN 11 city: EINDHOVEN postcode: 5611 ZS website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (EINDHOVEN)	participant	255˙374.00
8	JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN Organization address address: THEODOR W ADORNO PLATZ 1 city: FRANKFURT AM MAIN postcode: 60323 website: www.uni-frankfurt.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	249˙216.00
9	KLINIKUM DER UNIVERSITAET ZU KOELN KLINIKUM DER UNIVERSITAET ZU KOELN Organization address address: Kerpener Strasse 62 city: KOELN postcode: 50937 website: www.uk-koeln.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KOELN)	participant	249˙216.00
10	Deutsche Arthrosehilfe Deutsche Arthrosehilfe Organization address address: n.a. city: Frankfurt am Main postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Frankfurt am Main)	partner	0.00
11	Eli Lilly and Company Eli Lilly and Company Organization address address: n.a. city: Indianapolis postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UM (Indianapolis)	partner	0.00
12	Orthopaedic Research UK Orthopaedic Research UK Organization address address: n.a. city: London postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (London)	partner	0.00
13	STICHTING NATIONAAL REUMAFONDS STICHTING NATIONAAL REUMAFONDS Organization address address: DR J VAN BREEMENSTRAAT 4 city: AMSTERDAM postcode: 1056 AB website: http://www.reumafonds.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	partner	0.00

Map

Project objective

A well-functioning locomotor system is essential for human well-being. This is an important consideration in our aging population with the increased associated costs of ensuring high quality of life. Many people suffer from diseases of the locomotor system, such as bone defects or osteoarthritis, for which current treatments are insufficient. To develop new treatments, CarBon includes 6 academic partners, 3 companies and 3 charitable foundations, working together to train 14 young scientists. We will combine knowledge from the fields of tissue engineering, cartilage and bone developmental biology and pathobiology using skills from the disciplines of cell biology, computational modelling, biotechnology (bioreactors, biomaterials) and drug discovery.

In a multifactorial approach the network of young scientists will identify the biological and physical factors that determine the fate of cartilage. Understanding and controlling the dual character of cartilage is pivotal: insufficient transition impairs bone healing, and undesired transition to bone leads to osteoarthritis. State of the art in vitro, in silico and in vivo models will be uniquely combined to elucidate how this transition is orchestrated and how it can be modulated.

The main objectives of CarBon are: - To establish a network of 14 highly skilled early stage researchers (ESRs) equipped with essential knowledge, scientific expertise, transferable skills and societal awareness as a foundation for their future careers. ESRs will be trained in cutting edge technology, communication, intellectual property and valorisation. - To understand cartilage to bone transition, to identify targets to develop novel functionalised biomaterials and to discover therapeutic drugs that either prevent or stimulate cartilage to bone transitions. This will lead to new treatment options for large bone defects and osteoarthritis.

Deliverables

List of deliverables.
D6.1	Documents, reports	2019-07-05 15:23:53
D7.1	Websites, patent fillings, videos etc.	2019-07-05 15:23:53
D7.2	Websites, patent fillings, videos etc.	2019-07-05 15:23:53

Take a look to the deliverables list in detail: detailed list of CarBon deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Andrew Pitsillides, Soraia P Caetano-Silva Faculty of 1000 evaluation for Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand. published pages: , ISSN: , DOI: 10.3410/f.730362852.793539430		2020-04-07
2019	Cansu Gorgun, Daniele Reverberi, Gianluca Rotta, Federico Villa, Rodolfo Quarto, Roberta Tasso Isolation and Flow Cytometry Characterization of Extracellular-Vesicle Subpopulations Derived from Human Mesenchymal Stromal Cells published pages: e76, ISSN: 1941-7322, DOI: 10.1002/cpsc.76	Current Protocols in Stem Cell Biology 48/1	2019-08-29
2018	Behzad Javaheri, Soraia P. Caetano-Silva, Ioannis Kanakis, George Bou-Gharios, Andrew A. Pitsillides The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within? published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2018.00028	Frontiers in Bioengineering and Biotechnology 6	2019-07-05
2018	Raphaelle Lesage, Johan Kerkhofs, Liesbet Geris Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine published pages: , ISSN: 2296-4185, DOI: 10.3389/fbioe.2018.00165	Frontiers in Bioengineering and Biotechnology 6	2019-07-05

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The information about "CARBON" are provided by the European Opendata Portal: CORDIS opendata.