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OXYTRAIN SIGNED

Harnessing the power of enzymatic oxygen activation

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

OXYTRAIN project word cloud

Explore the words cloud of the OXYTRAIN project. It provides you a very rough idea of what is the project "OXYTRAIN" about.

translating reaction catalytic pharmaceuticals hydrolases reactions oxygenase oxygenation chemical mutual infancy convergence fertilization biotechnological selective tools biochemistry etn experts individual satisfy biotechnology hurdles oxygenases academic for biological joint biorefineries power groups beneficiaries solved exploited feasible cross catalyse entrepreneurial oxygenating skills nature multiple generation molecules textiles considering classes disciplines oxygen network industrial setting unrivalled stage supporting biocatalysts routes engineering metabolic training add perfect intersectoral esrs incorporation chemistry types enzymes oxidative conventional enzyme innovative oxytrain

Project "OXYTRAIN" data sheet

The following table provides information about the project.

Coordinator	RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	https://www.oxytrain.eu/
Total cost	3˙076˙435 €
EC max contribution	3˙076˙435 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	coordinator	922˙184.00
2	NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET Organization address address: UNIVERSITETSTUNET 3 city: AS postcode: 1433 website: http://www.nmbu.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (AS)	participant	286˙275.00
3	UNIVERSITY OF YORK UNIVERSITY OF YORK Organization address address: HESLINGTON city: YORK NORTH YORKSHIRE postcode: YO10 5DD website: http://www.york.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (YORK NORTH YORKSHIRE)	participant	273˙287.00
4	UNIVERSITA DEGLI STUDI DI PAVIA UNIVERSITA DEGLI STUDI DI PAVIA Organization address address: STRADA NUOVA 65 city: PAVIA postcode: 27100 website: www.unipv.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PAVIA)	participant	258˙061.00
5	TECHNISCHE UNIVERSITAET GRAZ TECHNISCHE UNIVERSITAET GRAZ Organization address address: RECHBAUERSTRASSE 12 city: GRAZ postcode: 8010 website: www.tugraz.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (GRAZ)	participant	255˙934.00
6	DSM FOOD SPECIALTIES BV DSM FOOD SPECIALTIES BV Organization address address: ALEXANDER FLEMINGLAAN 1 city: DELFT postcode: 2613 AX website: www.dsmfoodspecialties.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (DELFT)	participant	255˙374.00
7	RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN RHEINISCH-WESTFAELISCHE TECHNISCHE HOCHSCHULE AACHEN Organization address address: TEMPLERGRABEN 55 city: AACHEN postcode: 52062 website: www.rwth-aachen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (AACHEN)	participant	249˙216.00
8	SESAM-BIOTECH GMBH SESAM-BIOTECH GMBH Organization address address: FORCKENBECKSTRASSE 50 city: AACHEN postcode: 52074 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (AACHEN)	participant	249˙216.00
9	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Organization address address: SCHLOSSPLATZ 2 city: MUENSTER postcode: 48149 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	participant	249˙216.00
10	SANKO TEKSTIL ISLETMELERI SANAYI VETICARET ANONIM SIRKETI SANKO TEKSTIL ISLETMELERI SANAYI VETICARET ANONIM SIRKETI Organization address address: OSB 3 CADDE city: BURSA postcode: 16400 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	TR (BURSA)	participant	77˙668.00
11	bisy e.U. bisy e.U. Organization address address: Wetzawinkel 20A city: Hofstaetten / Raab postcode: 8200 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (Hofstaetten / Raab)	partner	0.00
12	BORREGAARD AS BORREGAARD AS Organization address address: HJALMAR WESSELS VEI 6 city: SARPSBORG postcode: 1721 website: www.borregaard.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (SARPSBORG)	partner	0.00
13	DSM CHEMICAL TECHNOLOGY R & D BV DSM CHEMICAL TECHNOLOGY R & D BV Organization address address: POSTSTRAAT 1 city: SITTARD postcode: 6135 KR website: www.dsm.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (SITTARD)	partner	0.00
14	INGENZA LIMITED INGENZA LIMITED Organization address address: WALLACE BUILDING ROSLIN BIOCENTRE city: ROSLIN postcode: EH25 9PP website: www.ingenza.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (ROSLIN)	partner	0.00
15	SYNCOM BV SYNCOM BV Organization address address: KADIJK 3 city: GRONINGEN postcode: 9747 AT website: www.syncom.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	partner	0.00

Map

Project objective

For the selective and effective incorporation of oxygen into biological molecules (oxygenation reaction), several enzyme types have evolved in nature. They catalyse crucial reactions in various metabolic routes. The chemistry feasible with these biocatalysts is unrivalled when compared with conventional chemical methods. Therefore, these oxygenating enzymes are very promising tools in biotechnological approaches. However, when compared with other enzyme classes, such as hydrolases, oxygenases are still in their infancy considering their biotechnological potential. To fully exploit the catalytic power of oxygenases, several hurdles have to be taken for which a higher level of knowledge on these enzymes is needed while also technical aspects have to be solved.

The European Training Network (ETN) OXYTRAIN is a joint academic/non-academic training initiative supporting the convergence of biochemistry, enzyme engineering and biotechnology. The consortium's mutual goal is developing a new generation of innovative and entrepreneurial early stage researchers (ESRs) to satisfy the need for knowledge and skills to produce and apply oxidative enzymes. This will be achieved by setting up a network and intersectoral programme in which multiple disciplines will be integrated and exploited. By bringing together 7 academic beneficiaries that are experts in the field of individual oxygenase groups, the network will provide perfect conditions for cross-fertilization of knowledge, while the 3 industrial beneficiaries and 5 partner organisations will add to the consortium by translating the generated knowledge into real industrial applications, such as textiles, pharmaceuticals and biorefineries.

Deliverables

List of deliverables.
Generation and transfer of six SSB mutant libraries to the RWTH/TUG partners for screening	Demonstrators, pilots, prototypes	2020-03-23 11:29:33
Libraries of enzyme mutants prepared	Documents, reports	2020-03-23 11:29:33
Cofactor-independent oxygenases with few new functions identified within the tautomerase superfamily	Documents, reports	2020-03-23 11:29:33
Identification of substrates and inhibitors of HPP oxygenase	Documents, reports	2020-03-23 11:29:33
PQS-cleaving cofactor-independent dioxygenases purified and functionally characterised	Documents, reports	2020-03-23 11:29:33
Libraries of LPMO mutants prepared	Demonstrators, pilots, prototypes	2020-03-23 11:29:33
Identification of amino acid positions that govern selectivity of three heme-dependent monooxygenases	Documents, reports	2020-03-23 11:29:33
Flavin-dependent monooxygenases produced and purified	Documents, reports	2020-03-23 11:29:33
OXYTRAIN vacancies advertised	Other	2020-03-23 11:29:32
Project Website	Websites, patent fillings, videos etc.	2020-03-23 11:29:32

Take a look to the deliverables list in detail: detailed list of OXYTRAIN deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Nico D. Fessner P450 Monooxygenases Enable Rapid Late-Stage Diversification of Natural Products via Câˆ’H Bond Activation published pages: , ISSN: 1867-3880, DOI: 10.1002/cctc.201801829	ChemCatChem	2020-03-23
2019	Nikola LonÄar, Filippo Fiorentini, Gautier Bailleul, Simone Savino, Elvira Romero, Andrea Mattevi, Marco W. Fraaije Characterization of a thermostable flavin-containing monooxygenase from Nitrincola lacisaponensis (NiFMO) published pages: 1755-1764, ISSN: 0175-7598, DOI: 10.1007/s00253-018-09579-w	Applied Microbiology and Biotechnology 103/4	2020-03-23

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The information about "OXYTRAIN" are provided by the European Opendata Portal: CORDIS opendata.