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METAGE SIGNED

Metamorphosis as a re-set mechanism of the ageing clock: is early-life stress bypassed by morphogenesis?

Total Cost €

EC-Contrib. €

Partnership

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METAGE project word cloud

Explore the words cloud of the METAGE project. It provides you a very rough idea of what is the project "METAGE" about.

domains xenopus length stress cellular rejuvenate vary larval stressors me later individuals differ newly accumulated biological independent trained metamorphic examine cycles life telomere metamorphosis biomarkers influences hypothesis levels larvae act stages successfully skills telomerase complete shortening previously understand remodelled biology group structures molecular training formed damage ageing model completely physiology measuring host species empirical exposed tissues oxidative laevis animal amphibian

Project "METAGE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2019
Duration (year-month-day)	from 2019-02-18 to 2021-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF GLASGOW UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	coordinator	183˙454.00

Map

Project objective

The overall aim of this proposal is to understand how early-life stress can affect later ageing biomarkers (oxidative stress, telomere shortening, and telomerase activity) in species with complex life-cycles, and in particular to test the completely new hypothesis that amphibian metamorphosis may act to rejuvenate tissues previously exposed to stress. The research objectives are: 1) to determine whether levels of ageing biomarkers vary across larval and metamorphic stages, 2) to investigate whether damage accumulated by larvae due to early-stress is reduced by metamorphosis and whether this differ between remodelled and newly formed tissues/structures, and 3) to examine whether early-stress influences cellular responses stressors to ageing biomarkers later in life. I will be trained by the host to adopt an empirical approach to measuring early-life stress and ageing (e.g. oxidative stress, telomere length, and telomerase activity) in species with complex life-cycles (using as a model Xenopus laevis individuals), and will learn new skills in several areas of animal physiology and molecular biology, which are needed to successfully complete the research objectives. This training will increase my experience in different biological domains and will help me to develop my independent research group in the EU.

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The information about "METAGE" are provided by the European Opendata Portal: CORDIS opendata.