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DismantlingNoise SIGNED

Dissecting the (epi)genetic origins of phenotypic variation and metabolic disease susceptibility

Total Cost €

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EC-Contrib. €

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Partnership

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 DismantlingNoise project word cloud

Explore the words cloud of the DismantlingNoise project. It provides you a very rough idea of what is the project "DismantlingNoise" about.

mutants    poorly    emergence    series    epigenome    mechanistic    weight    dozen    context    molecular    contribution    map    socio    stochastic    mechanisms    first    gene    interactions    risk    catalogue    completely    regulator    dissection    susceptibility    explanation    layers    variation    body    diabetes    current    buffer    epistasis    regulatory    resolution    trigger    models    place    feeding    c57bl6    eight    heart    economic    time    isogenic    obesity    framework    etiological    developmental    day    epigenetically    powerful    chromatin    builds    approximately    vary    genetic    bi    sensitized    epi    phenotypic    100    begin    amplify    environment    2030    unbiased    disease    phenome    plasticity    mapped    latter    chief    phenomics    prevalence    epigenetic    critical    regulation    billion    generates    functional    unprecedented    stable    perfect    stroke    estimates    matrix    mice    understand    examine    fat    worldwide   

Project "DismantlingNoise" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.ie-freiburg.mpg.de/pospisilik
 Total cost 1˙997˙853 €
 EC max contribution 1˙997˙853 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙997˙853.00

Map

 Project objective

Current estimates place the prevalence of obesity beyond 1 billion by the year 2030. As a critical risk factor for heart disease, diabetes and stroke, obesity represents one of the chief socio-economic challenges of our day. While studies have mapped a genetic framework for understanding obesity, the etiological contribution of several regulatory layers, and in particular epigenetic regulation, remain poorly understood. A perfect example, we know that isogenic C57Bl6/J mice can vary by as much as 100% in body weight upon high fat feeding; currently, we have no mechanistic explanation for the emergence of such phenotypic variation. Here, I propose three aims dedicated towards understanding the (epi)genetic control of phenotypic variation and disease susceptibility. First, we will catalogue epigenome and phenome variation to an unprecedented depth and resolution in the isogenic context. Next, we will examine two completely novel models of epigenetically sensitized bi-stable obesity and thus begin a mechanistic dissection of phenotypic variation. Finally, we will map a series of gene-gene and gene-environment epistasis interactions including eight models of developmental plasticity and approximately a dozen chromatin regulator mutants. The latter epistasis matrix will identify the molecular mechanisms that trigger, amplify and buffer phenotypic variation and stochastic obesity in mice. The functional (epi)phenomics approach is unique. It builds the first unbiased framework against which to understand developmental plasticity and phenotypic variation, and at the same time generates powerful resources for disease researchers worldwide.

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