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DismantlingNoise SIGNED

Dissecting the (epi)genetic origins of phenotypic variation and metabolic disease susceptibility

Total Cost €

0

EC-Contrib. €

0

Partnership

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 DismantlingNoise project word cloud

Explore the words cloud of the DismantlingNoise project. It provides you a very rough idea of what is the project "DismantlingNoise" about.

mice    stochastic    regulation    bi    isogenic    completely    heart    obesity    interactions    layers    framework    regulatory    amplify    perfect    series    critical    examine    latter    feeding    billion    first    molecular    gene    100    risk    functional    prevalence    environment    sensitized    powerful    socio    stroke    eight    unbiased    catalogue    poorly    place    understand    current    unprecedented    builds    etiological    time    mapped    epigenetically    models    c57bl6    chief    stable    body    trigger    phenome    begin    emergence    resolution    explanation    2030    map    mutants    mechanistic    diabetes    economic    mechanisms    contribution    day    vary    estimates    epigenetic    disease    variation    dissection    fat    dozen    epigenome    context    approximately    weight    susceptibility    phenotypic    worldwide    developmental    chromatin    phenomics    epistasis    epi    plasticity    genetic    regulator    matrix    generates    buffer   

Project "DismantlingNoise" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: Munich
postcode: 80539
website: www.mpg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website https://www.ie-freiburg.mpg.de/pospisilik
 Total cost 1˙997˙853 €
 EC max contribution 1˙997˙853 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (Munich) coordinator 1˙997˙853.00

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 Project objective

Current estimates place the prevalence of obesity beyond 1 billion by the year 2030. As a critical risk factor for heart disease, diabetes and stroke, obesity represents one of the chief socio-economic challenges of our day. While studies have mapped a genetic framework for understanding obesity, the etiological contribution of several regulatory layers, and in particular epigenetic regulation, remain poorly understood. A perfect example, we know that isogenic C57Bl6/J mice can vary by as much as 100% in body weight upon high fat feeding; currently, we have no mechanistic explanation for the emergence of such phenotypic variation. Here, I propose three aims dedicated towards understanding the (epi)genetic control of phenotypic variation and disease susceptibility. First, we will catalogue epigenome and phenome variation to an unprecedented depth and resolution in the isogenic context. Next, we will examine two completely novel models of epigenetically sensitized bi-stable obesity and thus begin a mechanistic dissection of phenotypic variation. Finally, we will map a series of gene-gene and gene-environment epistasis interactions including eight models of developmental plasticity and approximately a dozen chromatin regulator mutants. The latter epistasis matrix will identify the molecular mechanisms that trigger, amplify and buffer phenotypic variation and stochastic obesity in mice. The functional (epi)phenomics approach is unique. It builds the first unbiased framework against which to understand developmental plasticity and phenotypic variation, and at the same time generates powerful resources for disease researchers worldwide.

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The information about "DISMANTLINGNOISE" are provided by the European Opendata Portal: CORDIS opendata.

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