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EMbRACe SIGNED

Effective Multidrug Cocktails for Cancer

Total Cost €

EC-Contrib. €

Partnership

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EMbRACe project word cloud

Explore the words cloud of the EMbRACe project. It provides you a very rough idea of what is the project "EMbRACe" about.

patient goals successful drug designed groups wet performed motivated cocktails economic business combinations screening therapeutic cells exponentially approval epidemic pave appropriate adoption socio combined limited impossible invested treatment small poc astronomical global tests personalized approved material predicting cancer idea phases anticancer tumor mental ages formula pressing instance drugs stroke prevention exist heart disease diagnosis lab tested rigorous never experiments doses validate grows tremendous illness turn computing

Project "EMbRACe" data sheet

The following table provides information about the project.

Coordinator	WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Israel [IL]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2015-PoC
Funding Scheme	ERC-POC
Starting year	2016
Duration (year-month-day)	from 2016-11-01 to 2018-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	WEIZMANN INSTITUTE OF SCIENCE WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	coordinator	150˙000.00

Map

Project objective

Cancer is a global epidemic that affects all ages and socio-economic groups. In turn, tremendous resources are being invested in prevention, diagnosis, and treatment of cancer. For instance, over 1,000 anticancer drugs are currently in various phases of development and pre-approval testing, more than the number for heart disease, stroke, and mental illness combined. Finding multi-drug combinations for cancer is an increasingly pressing therapeutic challenge. However, screening all possible drug combinations is an impossible task because the number of experiments grows exponentially with the number of different drugs and doses. Therefore, highly effective combinations of already approved drugs may likely exist that have never been tested before at the appropriate doses, due the astronomical number of wet lab tests required to find these combinations. Motivated by this challenge, we have developed a novel method for computing the effects of high order combinations of drugs on cancer cells and predicting the best drug for a given tumor based only on a very small number of experiments. In turn, the goals of our PoC project are to further validate the potential of our formula by means of numerous rigorous tests and to establish the business potential of our idea. If successful, this PoC project will pave the way to the development and adoption of highly personalized drug cocktails that are designed based only on a limited number of measurements performed on patient-derived tumor material.

Publications

List of publications.
year	authors and title	journal	last update
2017	Anat Zimmer, Avichai Tendler, Itay Katzir, Avi Mayo, Uri Alon Prediction of drug cocktail effects when the number of measurements is limited published pages: e2002518, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.2002518	PLOS Biology 15/10	2019-06-13

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The information about "EMBRACE" are provided by the European Opendata Portal: CORDIS opendata.