ARTISYM SIGNED
Artificial endosymbiosis
Total Cost €
0EC-Contrib. €
0Partnership
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0ARTISYM project word cloud
Explore the words cloud of the ARTISYM project. It provides you a very rough idea of what is the project "ARTISYM" about.
Project "ARTISYM" data sheet
The following table provides information about the project.
| Coordinator |
TECHNISCHE UNIVERSITEIT EINDHOVEN
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 2˙500˙000 € |
| EC max contribution | 2˙500˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-AdG |
| Funding Scheme | ERC-ADG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2021-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | TECHNISCHE UNIVERSITEIT EINDHOVEN | NL (EINDHOVEN) | coordinator | 2˙500˙000.00 |
Map
Project objective
Living organisms have acquired new functionalities by uptake and integration of species to create symbiotic life-forms. This process of endosymbiosis has intrigued scientists over the years, albeit mostly from an evolution biology perspective. With the advance of chemical and synthetic biology, our ability to create molecular-life-like systems has increased tremendously, which enables us to build cell and organelle-like structures. However, these advances have not been taken to a level to study comprehensively if endosymbiosis can be applied to non-living systems or to integrate living with non-living matter. The aim of the research described in the ARTISYM proposal is to establish the field of artificial endosymbiosis. Two lines of research will be followed. First, we will incorporate artificial organelles in living cells to design hybrid cells with acquired functionality. This investigation is scientifically of great interest, as it will show us how to introduce novel compartmentalized pathways into living organisms. It also serves an important societal goal, as with these compartments dysfunctional cellular processes can be corrected. We will follow both a transient and a permanent approach. With the transient route biodegradable nanoreactors are introduced to supply living cells temporarily with novel function. Functionality is permanently introduced using genetic engineering to express protein-based nanoreactors in living cells, or via organelle transplantation of healthy mitochondria in diseased living cells. Secondly I aim to create artificial cells with the ability to perform endosymbiosis; the uptake and presence of artificial organelles in synthetic vesicles allows them to dynamically respond to their environment. Responses that are envisaged are shape changes, motility, and growth and division. Furthermore, the incorporation of natural organelles in liposomes provides biocatalytic cascades with the necessary cofactors to function in an artificial cell
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Hailong Che, Jan C. M. van Hest Adaptive Polymersome Nanoreactors published pages: 1092-1109, ISSN: 2199-692X, DOI: 10.1002/cnma.201900245 |
ChemNanoMat 5/9 | 2020-01-30 |
| 2019 |
Yigit Altay, Shoupeng Cao, Hailong Che, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest Adaptive Polymeric Assemblies for Applications in Biomimicry and Nanomedicine published pages: 4053-4064, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.9b01341 |
Biomacromolecules 20/11 | 2020-01-30 |
| 2019 |
Alexander F. Mason, N. Amy Yewdall, Pascal L. W. Welzen, Jingxin Shao, Marleen van Stevendaal, Jan C. M. van Hest, David S. Williams, Loai K. E. A. Abdelmohsen Mimicking Cellular Compartmentalization in a Hierarchical Protocell through Spontaneous Spatial Organization published pages: 1360-1365, ISSN: 2374-7943, DOI: 10.1021/acscentsci.9b00345 |
ACS Central Science 5/8 | 2020-01-30 |
| 2018 |
Hailong Che, Shoupeng Cao, Jan C. M. van Hest Feedback-Induced Temporal Control of “Breathing†Polymersomes To Create Self-Adaptive Nanoreactors published pages: 5356-5359, ISSN: 0002-7863, DOI: 10.1021/jacs.8b02387 |
Journal of the American Chemical Society 140/16 | 2019-06-13 |
| 2017 |
Imke A. B. Pijpers, Loai K. E. A. Abdelmohsen, David S. Williams, Jan C. M. van Hest Morphology Under Control: Engineering Biodegradable Stomatocytes published pages: 1217-1222, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.7b00723 |
ACS Macro Letters 6/11 | 2019-06-13 |
| 2017 |
Hailong Che, Bastiaan C. Buddingh\', Jan C. M. van Hest Self-Regulated and Temporal Control of a “Breathing†Microgel Mediated by Enzymatic Reaction published pages: 12581-12585, ISSN: 1433-7851, DOI: 10.1002/anie.201706716 |
Angewandte Chemie International Edition 56/41 | 2019-06-13 |
| 2017 |
Alexander F. Mason, Bastiaan C. Buddingh’, David S. Williams, Jan C. M. van Hest Hierarchical Self-Assembly of a Copolymer-Stabilized Coacervate Protocell published pages: 17309-17312, ISSN: 0002-7863, DOI: 10.1021/jacs.7b10846 |
Journal of the American Chemical Society 139/48 | 2019-06-13 |
| 2018 |
Lisanne M. P. E. van Oppen, Loai K. E. A. Abdelmohsen, Sjenet E. van Emst-de Vries, Pascal L. W. Welzen, Daniela A. Wilson, Jan A. M. Smeitink, Werner J. H. Koopman, Roland Brock, Peter H. G. M. Willems, David S. Williams, Jan C.M. van Hest Biodegradable Synthetic Organelles Demonstrate ROS Shielding in Human-Complex-I-Deficient Fibroblasts published pages: 917-928, ISSN: 2374-7943, DOI: 10.1021/acscentsci.8b00336 |
ACS Central Science 4/7 | 2019-06-13 |
| 2018 |
Jingxin Shao, Mona Abdelghani, Guizhi Shen, Shoupeng Cao, David S. Williams, Jan C. M. van Hest Erythrocyte Membrane Modified Janus Polymeric Motors for Thrombus Therapy published pages: 4877-4885, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b01772 |
ACS Nano 12/5 | 2019-06-03 |
| 2018 |
Suzanne B. P. E. Timmermans, Daan F. M. Vervoort, Lise Schoonen, Roeland J. M. Nolte, Jan C. M. van Hest Self-Assembly and Stabilization of Hybrid Cowpea Chlorotic Mottle Virus Particles under Nearly Physiological Conditions published pages: 3518-3525, ISSN: 1861-4728, DOI: 10.1002/asia.201800842 |
Chemistry - An Asian Journal 13/22 | 2019-06-03 |
| 2018 |
Shoupeng Cao, Loai K. E. A. Abdelmohsen, Jingxin Shao, Joep van den Dikkenberg, Enrico Mastrobattista, David S. Williams, Jan C. M. van Hest pH-Induced Transformation of Biodegradable Multilamellar Nanovectors for Enhanced Tumor Penetration published pages: 1394-1399, ISSN: 2161-1653, DOI: 10.1021/acsmacrolett.8b00807 |
ACS Macro Letters 7/11 | 2019-09-02 |
| 2019 |
Jingxin Shao, Imke A. B. Pijpers, Shoupeng Cao, David S. Williams, Xuehai Yan, Junbai Li, Loai K. E. A. Abdelmohsen, Jan C. M. van Hest Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano-Red Blood Cells published pages: 1801678, ISSN: 2198-3844, DOI: 10.1002/advs.201801678 |
Advanced Science 6/5 | 2019-09-02 |
| 2018 |
N. Amy Yewdall, Alexander F. Mason, Jan C. M. van Hest The hallmarks of living systems: towards creating artificial cells published pages: 20180023, ISSN: 2042-8898, DOI: 10.1098/rsfs.2018.0023 |
Interface Focus 8/5 | 2019-09-02 |
| 2018 |
Annelies C. Wauters, Imke A. B. Pijpers, Alexander F. Mason, David S. Williams, Jurjen Tel, Loai K. E. A. Abdelmohsen, Jan C.M. van Hest Development of Morphologically Discrete PEG–PDLLA Nanotubes for Precision Nanomedicine published pages: 177-183, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01245 |
Biomacromolecules 20/1 | 2019-09-02 |
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