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SOLUS SIGNED

Smart optical and ultrasound diagnostics of breast cancer

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

SOLUS project word cloud

Explore the words cloud of the SOLUS project. It provides you a very rough idea of what is the project "SOLUS" about.

life photons composition modal reducing tissue previously female cancer source pulsed parametric 54 countries shear edge mammographic detector health distance validating lipids point industries quantitative quality mortality penetration risk disciplinary needless domain unprecedented expertise elastography combining healthcare diagnosis savings characterization breast sensitivity invasive unthinkable gated dynamic additional chain huge players diffuse wave academic blood screening morphologic cutting imaging sources significantly engineers time radiologists collagen societal tomography optical millions innovative clinically small women levels solus push operate miniaturized physicists false single leadership techniques detectors biopsy components representing market clinical positive mechanical specificity cumulative unmet picosecond involvement care water first innovation 60 industrial optics ultrasounds functional contribution biophotonics laser trans photonics stiffness

Project "SOLUS" data sheet

The following table provides information about the project.

Coordinator	POLITECNICO DI MILANO Organization address address: PIAZZA LEONARDO DA VINCI 32 city: MILANO postcode: 20133 website: www.polimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.solus-project.eu
Total cost	3˙815˙260 €
EC max contribution	3˙815˙260 € (100%)
Programme	1. H2020-EU.2.1.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Information and Communication Technologies (ICT))
Code Call	H2020-ICT-2016-1
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-11-01 to 2021-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	POLITECNICO DI MILANO POLITECNICO DI MILANO Organization address address: PIAZZA LEONARDO DA VINCI 32 city: MILANO postcode: 20133 website: www.polimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	coordinator	726˙988.00
2	VERMON SA VERMON SA Organization address address: RUE GENERAL RENAULT 180 city: TOURS postcode: 37000 website: www.vermon.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (TOURS)	participant	555˙312.00
3	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 website: www.cea.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS 15)	participant	518˙783.00
4	SUPERSONIC IMAGINE SUPERSONIC IMAGINE Organization address address: 510 RUE RENE DESCARTES LES JARDINS DE LA DURANNE B ET BAT F city: AIX EN PROVENCE postcode: 13857 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (AIX EN PROVENCE)	participant	407˙500.00
5	MICRO PHOTON DEVICES S.R.L. MICRO PHOTON DEVICES S.R.L. Organization address address: Via Stradivari 4 city: BOLZANO postcode: 39100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BOLZANO)	participant	400˙711.00
6	EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG Organization address address: NEUTORGASSE 9/2 city: WIEN postcode: 1010 website: www.eibir.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	366˙250.00
7	IC-HAUS GMBH IC-HAUS GMBH Organization address address: AM KUEMMERLING 18 city: BODENHEIM postcode: 55294 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BODENHEIM)	participant	327˙000.00
8	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	300˙213.00
9	OSPEDALE SAN RAFFAELE SRL OSPEDALE SAN RAFFAELE SRL Organization address address: VIA OLGETTINA 60 city: MILANO postcode: 20132 website: www.hsr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	212˙500.00

Map

Project objective

SOLUS is a trans-disciplinary 54-month project bringing together 9 partners: industries (4), academic and clinical institutions from 5 countries (engineers, physicists and radiologists) representing cutting-edge expertise in their fields, to develop an innovative non-invasive, point-of-care, low-cost, easy-to-operate, multi-modal imaging system (diffuse optics and ultrasounds/shear wave elastography) for high-specificity diagnosis of breast cancer, the most common female cancer in Europe. Mammographic screening is effective in reducing mortality, however the 10-year cumulative false-positive risk is 50-60%, leading to needless additional invasive procedures (e.g. biopsy). The project addresses the unmet clinical need for higher specificity in breast cancer imaging following screening by fully combining photonics with non-photonics techniques, developing and clinically validating innovative and previously unthinkable photonics concepts and components: time-domain small source-detector distance optical tomography, miniaturized picosecond pulsed laser sources, high-dynamic-range time-gated single-photons detectors to achieve unprecedented sensitivity and depth penetration. For the first time, this allows a comprehensive quantitative characterization of breast tissue including composition (water, lipids, collagen), functional blood parameters, morphologic information and mechanical parameters (stiffness). This innovative multi-parametric characterization will significantly improve the specificity of breast screening, with great impact on the quality of life of millions of European women every year, and huge savings for the healthcare systems. The strong involvement of leading industrial players at all levels in the value chain will push the European innovation process and make a significant contribution to ensuring Europe’s industrial leadership in the biophotonics healthcare market, while addressing one of the largest societal challenges in health and well-being.

Deliverables

List of deliverables.
Performances assessment of optode components	Documents, reports	2020-03-24 10:48:46
Performance assessment of the single optode	Documents, reports	2020-03-24 10:49:22
Updated Data Management Plan	Open Research Data Pilot	2020-03-24 10:49:24
First release of the Data Management Plan	Open Research Data Pilot	2020-02-27 11:35:14
Definition of paradigms representing exemplary breast lesions cases	Documents, reports	2020-02-27 11:35:14
Design of multi-modal phantoms for DOT-US	Documents, reports	2020-02-27 11:35:15
Definition of protocols for system characterization	Documents, reports	2020-02-27 11:35:15
Definition of procedures for routine tests	Documents, reports	2020-02-27 11:35:15
Visual identity and online presence	Documents, reports	2020-02-27 11:35:14

Take a look to the deliverables list in detail: detailed list of SOLUS deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Edoardo Ferocino, Antonio Pifferi, Simon Arridge, Fabrizio Martelli, Paola Taroni, Andrea Farina Multi Simulation Platform for Time Domain Diffuse Optical Tomography: An Application to a Compact Hand-Held Reflectance Probe published pages: 2849, ISSN: 2076-3417, DOI: 10.3390/app9142849	Applied Sciences 9/14	2020-02-27
2018	Anurag Behera, Laura Di Sieno, Antonio Pifferi, Fabrizio Martelli, Alberto Dalla Mora Instrumental, optical and geometrical parameters affecting time-gated diffuse optical measurements: a systematic study published pages: 5524, ISSN: 2156-7085, DOI: 10.1364/boe.9.005524	Biomedical Optics Express 9/11	2020-02-27
2019	Laura Di Sieno, Davide Contini, Giuseppe Lo Presti, Lorenzo Cortese, Tony Mateo, Bogdan Rosinski, Elena Venturini, Pietro Panizza, Mireia Mora, Gloria Aranda, Mattia Squarcia, Andrea Farina, Turgut Durduran, Paola Taroni, Antonio Pifferi, Alberto Dalla Mora Systematic study of the effect of ultrasound gel on the performances of time-domain diffuse optics and diffuse correlation spectroscopy published pages: 3899, ISSN: 2156-7085, DOI: 10.1364/boe.10.003899	Biomedical Optics Express 10/8	2020-02-27
2017	Edoardo Ferocino, Edoardo Martinenghi, Alberto Dalla Mora, Antonio Pifferi, Rinaldo Cubeddu, Paola Taroni Attractive new technologies for 7-wavelength time domain optical mammography published pages: 1041202, ISSN: , DOI: 10.1117/12.2286058	Diffuse Optical Spectroscopy and Imaging VI	2020-02-27
2017	Alberto Tosi, Mirko Sanzaro, Mauro Buttafava, Alessandro Ruggeri, Enrico Conca, Marco Renna, Federica Villa, Franco Zappa Gating techniques for InGaAs/InP and silicon SPADs published pages: 177, ISSN: , DOI:	Single Photon Workshop 2017	2020-02-27
2016	Laura Di Sieno, Judy Zouaoui, Lionel HervÃ©, Antonio Pifferi, Andrea Farina, Edoardo Martinenghi, Jacques Derouard, Jean-Marc Dinten, Alberto Dalla Mora Time-domain diffuse optical tomography using silicon photomultipliers: feasibility study published pages: 116002, ISSN: 1083-3668, DOI: 10.1117/1.JBO.21.11.116002	Journal of Biomedical Optics 21/11	2020-02-27
2017	Judy Zouaoui, Laura Di Sieno, Lionel HervÃ©, Antonio Pifferi, Andrea Farina, Alberto Dalla Mora, Jacques Derouard, Jean-Marc Dinten Chromophore decomposition in multispectral time-resolved diffuse optical tomography published pages: 4772, ISSN: 2156-7085, DOI: 10.1364/BOE.8.004772	Biomedical Optics Express 8/10	2020-02-27
2018	Edoardo Ferocino, Edoardo Martinenghi, Alberto Dalla Mora, Antonio Pifferi, Rinaldo Cubeddu, Paola Taroni High throughput detection chain for time domain optical mammography published pages: 755, ISSN: 2156-7085, DOI: 10.1364/boe.9.000755	Biomedical Optics Express 9/2	2020-02-27
2017	Paola Taroni, Anna Maria Paganoni, Francesca Ieva, Antonio Pifferi, Giovanna Quarto, Francesca Abbate, Enrico Cassano, Rinaldo Cubeddu Non-invasive optical estimate of tissue composition to differentiate malignant from benign breast lesions: A pilot study published pages: 40683, ISSN: 2045-2322, DOI: 10.1038/srep40683	Scientific Reports 7	2020-02-27

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