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SCUBA CANCERS SIGNED

Finding the genetic causes of contagious metastases under the sea

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SCUBA CANCERS project word cloud

Explore the words cloud of the SCUBA CANCERS project. It provides you a very rough idea of what is the project "SCUBA CANCERS" about.

living natural bivalves found intends hosts environment leukemia cockle recurrently hn types drive cancers identification edule somatic drivers engineering vivo catalogue universal biological ngs driver genome insights approach transmissible figure ubiquity parasitic structure contagious genomic cockles genetic transmissibility marine depart naturally experimentation validation prevalence metastasis mechanisms individuals transmitted hemic transfer cancer unexpected cells operate evolve neoplasia first gene nearly unrelated cerastoderma validated 20 mutational discovery polyphyletic putative vitro opportunity gt phylogenetic alterations genes coast illuminating source model offers mutated cell clonally lineages clonal origins endless provides atlantic origin western editing occurring

Project "SCUBA CANCERS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://genomesdisease.tech/
Total cost	1˙492˙500 €
EC max contribution	1˙492˙500 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DE SANTIAGO DE COMPOSTELA UNIVERSIDAD DE SANTIAGO DE COMPOSTELA Organization address address: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N city: SANTIAGO DE COMPOSTELA postcode: 15782 website: http://www.usc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SANTIAGO DE COMPOSTELA)	coordinator	989˙463.00
2	UNIVERSIDAD DE VIGO UNIVERSIDAD DE VIGO Organization address address: LG CAMPUS LAGOAS MARCOSENDE city: VIGO PONTEVEDRA postcode: 36310 website: www.uvigo.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VIGO PONTEVEDRA)	participant	503˙036.00

Map

Project objective

Clonally transmissible cancers are somatic cell lineages that are transmitted between individuals via the transfer of living cancer cells. There are only three known types of naturally occurring clonally transmissible cancers, one of which is a leukemia-like cancer found in marine bivalves, called hemic neoplasia (HN). HN in cockles Cerastoderma edule offers an unique opportunity, over the other naturally occurring transmissible cancers, for the discovery of the genetic drivers of cancer transmissibility because: (1) cockle HN has a polyphyletic origin, which allows the identification of recurrently mutated genes among different unrelated cockle HN lineages; (2) HN provides a reliable in vitro and in vivo model that could be used for driver gene discovery and validation by means of genetic engineering methods; (3) cockle HN represents a nearly endless source of biological resources for study and experimentation on the origins and development of natural clonally transmissible cancers, due to the ubiquity of cockles throughout the Western Atlantic coast of Europe and the high prevalence of HN (>20%). Using HN in cockles as a model for clonally transmissible cancers, this project intends to identify the genomic alterations and mutational processes that drive transmissible cancers to depart from their hosts and evolve as parasitic clonal lineages in the marine environment, for illuminating universal processes that make a cancer contagious, and to identify new/unexpected biological insights into the general mechanisms of cancer metastasis. We will first characterize the clonal structure of cockle transmissible cancers by phylogenetic approaches. Then, we will use NGS analysis to catalogue the somatic alterations that characterize different HN clonal lineages, figure out the mutational processes that operate in marine transmissible cancers, and identify the putative cancer genes that drive cancer transmissibility, which will be finally validated by genome editing approach

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