Opendata, web and dolomites

PHOTO-BORAD

Boron chemistry in a new light: exploring the radical reactivity of boronate complexes through photochemical strategies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PHOTO-BORAD project word cloud

Explore the words cloud of the PHOTO-BORAD project. It provides you a very rough idea of what is the project "PHOTO-BORAD" about.

fundamental    cycle    organic    methodology    light    versatile    harbouring    rearrangement    endeavour    bonds    transfer    chiral    believe    create    positions    intermediate    groups    leaving    reactive    academic    irradiation    mechanistic    tremendously    previously    electrophilic    exploited    radicals    thereby    chemistry    migration    merge    trigger    adjacent    combining    creation    boronic    community    alkyl    molecule    readily    decade    solid    normally    employ    physical    react    scientific    boronate    pillars    host    transformations    photoredox    unconnected    involve    synthesis    complexes    group    emerge    researcher    species    proposing    oxidise    seek    oxidation    foundations    rearrangements    esters    boron    stereospecific    chemical    suite    ing    catalysis    reactions    forging    synthetic    last    links    visible    radical    emerged    vinyl    reported    enantioenriched    structures    carefully    transformation    starting    laying    mild    network    scope    metallate   

Project "PHOTO-BORAD" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.chm.bris.ac.uk/org/aggarwal/research.php
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-03-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 183˙454.00

Map

 Project objective

In the last decade photoredox reactions have emerged as tremendously versatile processes for organic synthesis, enabling reactive radical species to be generated at specific positions in an organic molecule under very mild conditions (visible-light irradiation). Over the same decade the host group have developed a suite of transformations exploiting the fundamental chemistry of boron, many of which involve 1,2-metallate rearrangement of boronate complexes. We now seek to merge these two major pillars of synthetic methodology, which are currently unconnected, to create a new field which we believe has significant potential for organic synthesis. We propose to react electrophilic radicals generated through photoredox catalysis with vinyl boronate complexes. Oxidation of the resulting intermediate radical during the photoredox cycle will trigger 1,2-alkyl migration, creating new C-C and C-B bonds. 1,2-Metallate rearrangements normally employ leaving groups adjacent to boron but here we are proposing to oxidise a radical adjacent to a boronate to achieve the same transformation, a process that has not been previously reported. 1,2-Metallate rearrangements are stereospecific, and this will be exploited in the creation of enantioenriched products starting from readily available chiral boronic esters. The scope of the process will be carefully investigated, and mechanistic studies will be carried out using advanced physical/chemical methods, thereby laying solid foundations for the development of this new field. By combining two major fields of endeavour, novel chemistry will emerge with new structures harbouring novel properties for exploitation. Furthermore this project will enable significant knowledge transfer between host and researcher, while forging new academic network links within the scientific community.

 Publications

year authors and title journal last update
List of publications.
2018 Mattia Silvi, Raffael Schrof, Adam Noble, Varinder K. Aggarwal
Enantiospecific Three-Component Alkylation of Furan and Indole
published pages: 4279-4282, ISSN: 0947-6539, DOI: 10.1002/chem.201800527
Chemistry - A European Journal 24/17 2019-09-02
2017 Mattia Silvi, Christopher Sandford, Varinder K. Aggarwal
Merging Photoredox with 1,2-Metallate Rearrangements: The Photochemical Alkylation of Vinyl Boronate Complexes
published pages: 5736-5739, ISSN: 0002-7863, DOI: 10.1021/jacs.7b02569
Journal of the American Chemical Society 139/16 2019-09-02
2018 Mattia Silvi, Paolo Melchiorre
Enhancing the potential of enantioselective organocatalysis with light
published pages: 41-49, ISSN: 0028-0836, DOI: 10.1038/nature25175
Nature 554/7690 2019-09-02

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PHOTO-BORAD" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PHOTO-BORAD" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

OSeaIce (2019)

Two-way interactions between ocean heat transport and Arctic sea ice

Read More  

ACES (2019)

Antarctic Cyclones: Expression in Sea Ice

Read More  

EcoSpy (2018)

Leveraging the potential of historical spy satellite photography for ecology and conservation

Read More