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SILICOFCM SIGNED

In Silico trials for drug tracing the effects of sarcomeric protein mutations leading to familial cardiomyopathy

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

SILICOFCM project word cloud

Explore the words cloud of the SILICOFCM project. It provides you a very rough idea of what is the project "SILICOFCM" about.

tools storage hcm regulatory artery reports resonance treatment fundamentally vivo magnetic hypertrophic flow disease data platforms time distributed coronary bsc society clinical protein performance therapies models efficient ul fcm familial tech loading optimized unew therapy abnormalities functional prospective mri echocardiography diagnosed drug bioinformatics progress cardiology imaging icvdv dcm platform cardiomyopathy image unifi ventricular classifications academic monitored dilated kinetic stopped outcome silico unexplained arvc myocardium uw cloud charge upmc limiting either symptoms reduce uoi mutation integration rcm animal computing bioirc silicofcm integrate arrhythmogenic sme abnormal computer course experiments right reasonably computational retrospective company 2014 according uhreg sbg structural molecular cardiomyopathies restrictive unikent vitro muscle assays heart guidelines cardiac iit responsible

Project "SILICOFCM" data sheet

The following table provides information about the project.

Coordinator	ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO Organization address address: PRVOSLAVA STOJANOVICA STREET 6 city: KRAGUJEVAC postcode: 34000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Serbia [RS]
Project website	https://silicofcm.eu/
Total cost	5˙507˙441 €
EC max contribution	5˙507˙441 € (100%)
Programme	1. H2020-EU.3.1.5. (Methods and data)
Code Call	H2020-SC1-2017-CNECT-2
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-06-01 to 2021-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO ISTRAZIVACKO RAZVOJNI CENTAR ZA BIOINZENJERING BIOIRC DOO Organization address address: PRVOSLAVA STOJANOVICA STREET 6 city: KRAGUJEVAC postcode: 34000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	RS (KRAGUJEVAC)	coordinator	653˙000.00
2	UNIVERSITY OF NEWCASTLE UPON TYNE UNIVERSITY OF NEWCASTLE UPON TYNE Organization address address: KINGS GATE city: NEWCASTLE UPON TYNE postcode: NE1 7RU website: http://www.ncl.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NEWCASTLE UPON TYNE)	participant	604˙090.00
3	UNIVERSITY OF WASHINGTON UNIVERSITY OF WASHINGTON Organization address address: BROOKLYN AVENUE NE 4333 city: SEATTLE WA postcode: 98195 9472 website: http://www.washington.edu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (SEATTLE WA)	participant	450˙201.00
4	INSTITUT ZA KARDIOVASKULARNE BOLESTI VOJVODINE INSTITUT ZA KARDIOVASKULARNE BOLESTI VOJVODINE Organization address address: PUT DOKTORA GOLDMANA 4 city: SREMSKA KAMENICA postcode: 21204 website: www.ikvbv.ns.ac.rs contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	RS (SREMSKA KAMENICA)	participant	445˙750.00
5	Illinois Institute of Technology Illinois Institute of Technology Organization address address: 10 W. 35th Street, Suite 7D7-1 city: CHICAGO IL postcode: 60616 website: www.iit.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (CHICAGO IL)	participant	417˙750.00
6	UNIVERSITY OF KENT UNIVERSITY OF KENT Organization address address: THE REGISTRY CANTERBURY city: CANTERBURY, KENT postcode: CT2 7NZ website: www.kent.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CANTERBURY, KENT)	participant	413˙550.00
7	SORBONNE UNIVERSITE SORBONNE UNIVERSITE Organization address address: 21 RUE DE L'ECOLE DE MEDECINE city: PARIS postcode: 75006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	396˙625.00
8	KLINIKUM DER UNIVERSITAET REGENSBURG KLINIKUM DER UNIVERSITAET REGENSBURG Organization address address: FRANS JOSEF STRAUSS ALLEE 11 city: REGENSBURG postcode: 93053 website: www-cgi.uni-regensburg.de/Klinik/Klinikum/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (REGENSBURG)	participant	374˙625.00
9	BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION BARCELONA SUPERCOMPUTING CENTER - CENTRO NACIONAL DE SUPERCOMPUTACION Organization address address: Calle Jordi Girona 31 city: BARCELONA postcode: 8034 website: www.bsc.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	342˙375.00
10	SEVEN BRIDGES GENOMICS INC SEVEN BRIDGES GENOMICS INC Organization address address: 1 MAIN STREET 500 city: CAMBRIDGE MA postcode: 2142 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (CAMBRIDGE MA)	participant	339˙375.00
11	UNIVERSITA DEGLI STUDI DI FIRENZE UNIVERSITA DEGLI STUDI DI FIRENZE Organization address address: Piazza San Marco 4 city: Florence postcode: 50121 website: http://www.unifi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (Florence)	participant	327˙475.00
12	STEINBEIS ADVANCED RISK TECHNOLOGIES GMBH STEINBEIS ADVANCED RISK TECHNOLOGIES GMBH Organization address address: FANGELSBACHSTRASSE 14 city: STUTTGART postcode: 70178 website: www.risk-technologies.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (STUTTGART)	participant	278˙750.00
13	PANEPISTIMIO IOANNINON PANEPISTIMIO IOANNINON Organization address address: PANEPISTEMIOYPOLE PANEPISTEMIO IOANNINON city: IOANNINA postcode: 45110 website: www.uoi.gr / www.rc.uoi.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (IOANNINA)	participant	276˙375.00
14	UNIVERZA V LJUBLJANI UNIVERZA V LJUBLJANI Organization address address: KONGRESNI TRG 12 city: LJUBLJANA postcode: 1000 website: http://www.uni-lj.si contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SI (LJUBLJANA)	participant	187˙500.00

Map

Project objective

According to the 2014 European Society of Cardiology Guidelines, cardiomyopathies are defined as structural and functional abnormalities of the ventricular myocardium that are unexplained by flow limiting coronary artery disease or abnormal loading conditions. There are four major classifications of cardiomyopathy: hypertrophic (HCM), dilated (DCM), restrictive (RCM), and arrhythmogenic right ventricular (ARVC). Familial cardiomyopathies (FCM) are most commonly diagnosed, or progress of the disease is monitored, through in vivo imaging, with either echocardiography or, increasingly, cardiac magnetic resonance imaging (MRI). The treatment of symptoms of FCM by established therapies could only in part improve the outcome, but novel therapies need to be developed to affect the disease process and time course more fundamentally. SILICOFCM project will develop in silico computational cloud platform which will integrate from stopped-flow molecular kinetic assays to magnetic resonance imaging of the whole heart, bioinformatics and image processing tools with state of the art computer models with the aim to reduce animal and clinical studies for a new drug development and optimized clinical therapy of FCM. The developed system will be distributed on the cloud platforms in order to achieve efficient data storage and high-performance computing, that can offer end users results in reasonably short time. Academic technical partners IIT, UOI, UL and BSC will be responsible for developing and integration of in silico cloud computational platform with multi-scale cardiac muscle modelling which include experiments on protein mutation in vitro from UNIKENT, UNIFI and UW. Bioinformatics tools will be integrated by US company SBG. Clinical partners UNEW, ICVDV, UPMC and UHREG will do retrospective and prospective studies. SME partner R-Tech will be in charge of regulatory issues and reports and BIOIRC will do the exploitation of the project.

Deliverables

List of deliverables.
SILICOFCM flyers	Other	2019-07-23 15:45:40
Imaging acquisition data	Documents, reports	2019-07-23 15:45:34
SILICOFCM Cloud platform	Documents, reports	2019-07-23 15:45:48
Project Website	Other	2019-07-23 15:45:37
Project videos	Other	2019-07-23 15:45:45
Road map on Business Model v1	Documents, reports	2019-07-23 15:45:29
Software: Upgrade FE simulation	Documents, reports	2019-07-23 15:45:45
SILICOFCM Reference Architecture	Documents, reports	2019-07-23 15:45:33

Take a look to the deliverables list in detail: detailed list of SILICOFCM deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Chloe A. Johnson, Jonathan Walklate, Marina Svicevic, Srboljub M. Mijailovich, Carlos Vera, Anastasia Karabina, Leslie A. Leinwand, Michael A. Geeves The ATPase cycle of Human Muscle Myosin II Isoforms: Adaptation of a single mechanochemical cycle for different physiological roles published pages: , ISSN: , DOI:	BioRxiv	2019-08-29
2019	Sarah Charman, Nduka Okwose, Gregory Maniatopoulos, Sara Graziadio, Tamara Metzler, Helen Banks, Luke Vale, Guy A MacGowan, Petar M SeferoviÄ‡, Ahmet Fuat, Christi Deaton, Jonathan Mant, Richard F D Hobbs, Djordje G Jakovljevic Opportunities and challenges of a novel cardiac output response to stress (CORS) test to enhance diagnosis of heart failure in primary care: qualitative study published pages: e028122, ISSN: 2044-6055, DOI: 10.1136/bmjopen-2018-028122	BMJ Open 9/4	2019-08-29
2019	J. Walklate, Zoltan Ujfalusi, Vincent Behrens, Edward J. King, Michael A. Geeves A micro-volume adaptation of a stopped-flow system; use with Î¼g quantities of muscle proteins published pages: 113338, ISSN: 0003-2697, DOI: 10.1016/j.ab.2019.06.009	Analytical Biochemistry 581	2019-08-29
2019	Nicoletta Piroddi, E. Rosalie Witjas-Paalberends, Claudia Ferrara, Cecilia Ferrantini, Giulia Vitale, Beatrice Scellini, Paul J.M. Wijnker, Vasco Sequiera, Dennis Dooijes, Cristobal dos Remedios, Saskia Schlossarek, Man Ching Leung, Andrew Messer, Douglas G. Ward, Annibale Biggeri, Chiara Tesi, Lucie Carrier, Charles S. Redwood, Steven B. Marston, Jolanda van der Velden, Corrado Poggesi The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM published pages: 18-29, ISSN: 0022-1295, DOI: 10.1085/jgp.201812160	The Journal of General Physiology 151/1	2019-08-05
2018	Miljan Milosevic, Dusica Stojanovic, Vladimir Simic, Bogdan Milicevic, Andjela Radisavljevic, Petar Uskokovic, Milos Kojic A Computational Model for Drug Release from PLGA Implant published pages: 2416, ISSN: 1996-1944, DOI: 10.3390/ma11122416	Materials 11/12	2019-08-05
2019	Milos Parovic, Nduka C. Okwose, Kristian Bailey, Lazar Velicki, Zlatko Fras, Petar M. Seferovic, Guy A. MacGowan, Djordje G. Jakovljevic NTâ€proBNP is a weak indicator of cardiac function and haemodynamic response to exercise in chronic heart failure published pages: 449-454, ISSN: 2055-5822, DOI: 10.1002/ehf2.12424	ESC Heart Failure 6/2	2019-08-05
2019	Giulia Vitale, Erica Lazzeri, Irene Costantini, Francesco Giardini, Giacomo Mazzamuto, Claudia Crocini, Nicoletta Piroddi, Beatrice Scellini, Manuel J. Pioner, Cecilia Ferrantini, Chiara Tesi, Francesco S. Pavone, Leonardo Sacconi, Corrado Poggesi Advanced Morpho-Functional Analysis on Ventricular and Atrial Tissue Reveals Cross-Bridge Kinetics Alterations and Sarcomere Energetic Impairment in Hcm Patients published pages: 29a, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2018.11.198	Biophysical Journal 116/3	2019-08-05
2019	Carlos D Vera, Chloe A Johnson, Jonathan Walklate, Arjun Adhikari, Zoltan Ujfalusi, Marina Svicevic, Srba M Mijailovich, Ariana Combs, Stephen J. Langer, Kathleen M. Ruppel, James A. Spudich, Leslie A. Leinwand, Michael A. Geeves Pediatric and adult-onset HCM mutations in the myosin motor domain have similar properties published pages: , ISSN: , DOI:		2019-08-05
2019	Srboljub M. Mijailovich, Momcilo Prodanovic, Lazar Vasovic, Boban Stojanovic, Mladen Maric, Danica Prodanovic, Joseph D. Powers, Jennifer Davis, Michael A. Geeves, Michael Regnier Modulation of Calcium Sensitivity and Twitch Contractions in Cardiac Muscle with Troponin-C Mutations: Simulations and Experiments published pages: 116a, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2018.11.654	Biophysical Journal 116/3	2019-08-05
2019	Samuel Sossalla, Christine Meindl, Marcus Fischer, Matthias Lubnow, Thomas MÃ¼ller, Lars S. Maier Bail-Out Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy in a Patient With Takotsubo Cardiomyopathy-Induced Cardiogenic Shock published pages: , ISSN: 1941-7640, DOI: 10.1161/circinterventions.118.007425	Circulation: Cardiovascular Interventions 12/2	2019-08-05
2019	M. Kojic, M. Milosevic, V. Simic, V. Geroski, A. Ziemys, N. Filipovic, M. Ferrari Smeared multiscale finite element model for electrophysiology and ionic transport in biological tissue published pages: 288-304, ISSN: 0010-4825, DOI: 10.1016/j.compbiomed.2019.03.023	Computers in Biology and Medicine 108	2019-08-05
2019	Aaron Koshy, Nduka C. Okwose, David Nunan, Anet Toms, David A. Brodie, Patrick Doherty, Petar Seferovic, Arsen Ristic, Lazar Velicki, Nenad Filipovic, Dejana Popovic, Jane Skinner, Kristian Bailey, Guy A. MacGowan, Djordje G. Jakovljevic Association between heart rate variability and haemodynamic response to exercise in chronic heart failure published pages: 77-82, ISSN: 1401-7431, DOI: 10.1080/14017431.2019.1590629	Scandinavian Cardiovascular Journal 53/2	2019-08-05
2019	Srboljub M. Mijailovich, Boban Stojanovic, Djordje Nedic, Marina Svicevic, Michael A. Geeves, Thomas C. Irving, Henk L. Granzier Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity published pages: 680-704, ISSN: 0022-1295, DOI: 10.1085/jgp.201812165	The Journal of General Physiology 151/5	2019-08-05
2019	Federica Sacco Quantification of the influence of detailed endocardial structures on human cardiac haemodynamics and electrophysiology using HPC published pages: , ISSN: , DOI:		2019-08-30
2019	Xin Gao, Djordje G. Jakovljevic, Daniel A. Beard Cardiac Metabolic Limitations Contribute to Diminished Performance of the Heart in Aging published pages: , ISSN: 0006-3495, DOI: 10.1016/j.bpj.2019.06.026	Biophysical Journal	2019-08-30

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