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INFRAVEC2 SIGNED

Research Infrastructures for the control of vector-borne diseases

Total Cost €

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EC-Contrib. €

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Partnership

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Project "INFRAVEC2" data sheet

The following table provides information about the project.

Coordinator
INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website https://infravec2.eu
 Total cost 9˙998˙845 €
 EC max contribution 9˙998˙845 € (100%)
 Programme 1. H2020-EU.1.4.1.2. (Integrating and opening existing national and regional  research infrastructures of European interest)
 Code Call H2020-INFRAIA-2016-1
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-02-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 1˙275˙929.00
2    POLO D'INNOVAZIONE DI GENOMICA, GENETICA E BIOLOGIA SCARL IT (SIENA) participant 983˙682.00
3    INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT FR (MARSEILLE) participant 912˙055.00
4    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 762˙346.00
5    IDRYMA TECHNOLOGIAS KAI EREVNAS EL (IRAKLEIO) participant 680˙887.00
6    UNIVERZITA KARLOVA CZ (PRAHA 1) participant 607˙750.00
7    THE PIRBRIGHT INSTITUTE LBG UK (WOKING) participant 584˙983.00
8    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 536˙625.00
9    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 473˙437.00
10    TROPIQ HEALTH SCIENCES NL (NIJMEGEN) participant 415˙400.00
11    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) participant 381˙680.00
12    INSTITUT DE RECERCA I TECNOLOGIA AGROALIMENTARIES ES (CALDES DE MONTBUI BARCELONA) participant 375˙922.00
13    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 316˙185.00
14    UNIVERSITAT ZURICH CH (ZURICH) participant 302˙232.00
15    CENTRO AGRICOLTURA E AMBIENTE GIORGIO NICOLI SRL IT (CREVALCORE) participant 278˙890.00
16    CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LEDEVELOPPEMENT - C.I.R.A.D. EPIC FR (PARIS) participant 226˙651.00
17    Fondation Health Sciences e-Training CH (Lausanne) participant 191˙687.00
18    WAGENINGEN UNIVERSITY NL (WAGENINGEN) participant 188˙787.00
19    INSTITUT PASTEUR DE DAKAR SN (DAKAR) participant 101˙250.00
20    UNIVERSITE DES SCIENCES DES TECHNIQUES ET DES TECHNOLOGIES DE BAMAKO ML (BAMAKO) participant 101˙000.00
21    MINISTERE DE LA SANTE BF (Ouagadougou) participant 100˙510.00
22    INSTITUT PASTEUR DE NOUVELLE-CALEDONIE NC (NOUMEA) participant 92˙526.00
23    LIVERPOOL SCHOOL OF TROPICAL MEDICINE UK (LIVERPOOL) participant 62˙812.00
24    Univerzitet u Novom Sadu, Poljoprivredni fakultet Novi Sad RS (NOVI SAD) participant 45˙612.00

Map

 Project objective

The overall objective of the Infravec2 project is to integrate key specialized research facilities necessary for European excellence in insect vector biology, to open the infrastructure for European access, and to develop new vector control measures targeting the greatest threats to human health and animal industries. Infravec2 is an Advanced Community, following a four-year Starting Community lifecycle (FP7 Infravec1). Lack of access to key infrastructures limits European vector research and impedes development of vector control measures. Insect vectors transmit parasitic diseases such as malaria and leishmaniasis, and viral infections such as chikungunya, dengue, Zika, Japanese encephalitis and yellow fever. Vector-borne diseases, which have historically been a problem of tropical countries, now represent a threat for temperate regions of the world including much of Europe. The 24 consortium partners, including 4 commercial companies, hold the major European biosecure insectaries for experimental infection and containment of insect vectors under Containment Level 2 and 3 (CL2/CL3) conditions, other key insect vector facilities, and include front-line field sites in Africa, the Pacific, and the Americas. Infravec2 will implement comparable standards across the secure insectary facilities as a world first, improving exploitation of European vector infrastructures for research and public health, and will develop other innovative methodologies and technologies. Networking activities will assure that the project achieves full impact, producing a step change in European vector biology research and the product pipeline, and consolidating European global leadership in insect vectors. The goal of the Infravec2 project is to build a durable European infrastructure to control insect vector-borne disease, including with power to predict and prevent the inevitable next epidemic outbreak in advance.

 Deliverables

List of deliverables.
Standard protocols and baselines: Plasmodium-Anopheles infections Documents, reports 2020-03-23 11:38:21
Standard protocols and baselines: arbovirus-Aedes infections Documents, reports 2020-03-23 11:38:21
Rules and procedures to implement the Transnational access Documents, reports 2020-03-23 11:38:21
Report on strengths, gaps and needs for reinforcement among emergence zone partners Documents, reports 2020-03-23 11:38:21
Standard protocols and baselines: Leishmania-sand fly infections Documents, reports 2020-03-23 11:38:21
Guidelines and criteria for assessing the suitability of candidate end users for receiving Vectors and Derived Products, and for physical access to facilities Documents, reports 2020-03-23 11:38:21
Protocols for alternative rearing/infection/incubation conditions Documents, reports 2020-03-23 11:38:21
The European CL2/CL3 insectary containment and design standards are published for comment Websites, patent fillings, videos etc. 2020-03-23 11:38:21
TNA portal and tools for access to the repository Websites, patent fillings, videos etc. 2020-03-23 11:38:21
Product development: Validation of individual assays for the ArboVec-Disk for species ID, insecticide resistance traits and pathogens/symbionts Documents, reports 2020-03-23 11:38:20

Take a look to the deliverables list in detail:  detailed list of INFRAVEC2 deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Akira J. T. Alexander, Marie-Pierre Confort, Sophie Desloire, James I. Dunlop, Srikeerthana Kuchi, Vattipally B. Sreenu, Daniel Mair, Gavin S. Wilkie, Ana Da Silva Filipe, Benjamin Brennan, Maxime Ratinier, Frédérick Arnaud, Alain Kohl
Development of a Reverse Genetics System for Toscana Virus (Lineage A)
published pages: 411, ISSN: 1999-4915, DOI: 10.3390/v12040411
Viruses 12/4 2020-04-24
2020 Nazli Ayhan, Jorian Prudhomme, Lison Laroche, Anne-Laure Bañuls, Remi N. Charrel
Broader Geographical Distribution of Toscana Virus in the Mediterranean Region Suggests the Existence of Larger Varieties of Sand Fly Vectors
published pages: 114, ISSN: 2076-2607, DOI: 10.3390/microorganisms8010114
Microorganisms 8/1 2020-04-15
2020 Olivia J. S. Macleod, Jean-Mathieu Bart, Paula MacGregor, Lori Peacock, Nicholas J. Savill, Svenja Hester, Sophie Ravel, Jack D. Sunter, Camilla Trevor, Steven Rust, Tristan J. Vaughan, Ralph Minter, Shabaz Mohammed, Wendy Gibson, Martin C. Taylor, Matthew K. Higgins, Mark Carrington
A receptor for the complement regulator factor H increases transmission of trypanosomes to tsetse flies
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-020-15125-y
Nature Communications 11/1 2020-03-24
2020 Ignazio Graziosi, Carles Aranda, Fabrizio Balestrino, Romeo Bellini, Núria Busquets, Mammadou Coulibaly, Andrea Crisanti, Diawo Diallo, Mawlouth Diallo, Alioune Gaye, Moussa Guelbeogo, Aleksandra Ignjatović-Ćupina, Sebastián Napp, Sagnon N’Falé, Dušan Petrić, Paola Pollegioni, Alekos Simoni, Marija Zgomba, Ruth Müller
A litmus test for harmonized mosquito monitoring across Europe and Africa
published pages: , ISSN: , DOI: 10.1101/2020.01.30.927020
2020-03-24
2019 Marina Mariconti, Thomas Obadia, Laurence Mousson, Anna Malacrida, Giuliano Gasperi, Anna-Bella Failloux, Pei-Shi Yen
Estimating the risk of arbovirus transmission in Southern Europe using vector competence data
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-54395-5
Scientific Reports 9/1 2020-03-23
2019 Kevin L Howe, Bruno Contreras-Moreira, Nishadi De Silva, Gareth Maslen, Wasiu Akanni, James Allen, Jorge Alvarez-Jarreta, Matthieu Barba, Dan M Bolser, Lahcen Cambell, Manuel Carbajo, Marc Chakiachvili, Mikkel Christensen, Carla Cummins, Alayne Cuzick, Paul Davis, Silvie Fexova, Astrid Gall, Nancy George, Laurent Gil, Parul Gupta, Kim E Hammond-Kosack, Erin Haskell, Sarah E Hunt, Pankaj Jaiswal,
Ensembl Genomes 2020—enabling non-vertebrate genomic research
published pages: D689-D695, ISSN: 0305-1048, DOI: 10.1093/nar/gkz890
Nucleic Acids Research 48/D1 2020-03-23
2019 Marie Vazeille, Yoann Madec, Laurence Mousson, Rachel Bellone, Hélène Barré-Cardi, Carla Alexandra Sousa, Davy Jiolle, André Yébakima, Xavier de Lamballerie, Anna-Bella Failloux
Zika virus threshold determines transmission by European Aedes albopictus mosquitoes
published pages: 1668-1678, ISSN: 2222-1751, DOI: 10.1080/22221751.2019.1689797
Emerging Microbes & Infections 8/1 2020-03-23
2018 Anthony James Wilson, Lara Ellen Harrup
Reproducibility and relevance in insect-arbovirus infection studies
published pages: 105-112, ISSN: 2214-5745, DOI: 10.1016/j.cois.2018.05.007
Current Opinion in Insect Science 28 2020-03-23
2019 Slavica Vaselek, Jorian Prudhomme, Jitka Myskova, Tereza Lestinova, Tatiana Spitzova, Anne-Laure Bañuls, Petr Volf
Comparative Study of Promastigote- and Amastigote-Initiated Infection of Leishmania infantum (Kinetoplastida: Trypanosomatidae) in Phlebotomus perniciosus (Diptera: Psychodidae) Conducted in Different Biosafety Level Laboratories
published pages: , ISSN: 0022-2585, DOI: 10.1093/jme/tjz199
Journal of Medical Entomology 2020-03-23
2019 Nadège Gouignard, Floriane Cherrier, Emma Brito-Fravallo, Adrien Pain, Natalia Marta Zmarlak, Katia Cailliau, Corinne Genève, Kenneth D. Vernick, Colette Dissous, Christian Mitri
Dual role of the Anopheles coluzzii Venus Kinase Receptor in both larval growth and immunity
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-40407-x
Scientific Reports 9/1 2020-03-23
2018 J. Risueño, T. Spitzová, L. J. Bernal, C. Muñoz, M. C. López, M. C. Thomas, J. J. Infante, P. Volf, E. Berriatua
Longitudinal monitoring of anti‐saliva antibodies as markers of repellent efficacy against Phlebotomus perniciosus and Phlebotomus papatasi in dogs
published pages: 99-109, ISSN: 0269-283X, DOI: 10.1111/mve.12343
Medical and Veterinary Entomology 33/1 2020-03-23
2019 Mary Kefi, Vasileia Balabanidou, Vassilis Douris, Gareth Lycett, René Feyereisen, John Vontas
Two functionally distinct CYP4G genes of Anopheles gambiae contribute to cuticular hydrocarbon biosynthesis
published pages: 52-59, ISSN: 0965-1748, DOI: 10.1016/j.ibmb.2019.04.018
Insect Biochemistry and Molecular Biology 110 2020-03-23
2019 Slavica Vaselek, Petr Volf
Experimental infection of Phlebotomus perniciosus and Phlebotomus tobbi with different Leishmania tropica strains
published pages: , ISSN: 0020-7519, DOI: 10.1016/j.ijpara.2019.05.009
International Journal for Parasitology 2020-03-23
2019 Magdalena Jancarova, Laurence Bichaud, Jana Hlavacova, Stephane Priet, Nazli Ayhan, Tatiana Spitzova, Petr Volf, Remi Charrel
Experimental Infection of Sand Flies by Massilia Virus and Viral Transmission by Co-Feeding on Sugar Meal
published pages: 332, ISSN: 1999-4915, DOI: 10.3390/v11040332
Viruses 11/4 2020-03-23
2018 Vasileia Balabanidou, Linda Grigoraki, John Vontas
Insect cuticle: a critical determinant of insecticide resistance
published pages: 68-74, ISSN: 2214-5745, DOI: 10.1016/j.cois.2018.03.001
Current Opinion in Insect Science 27 2020-03-23
2017 Gildas A. Yahouédo, Fabrice Chandre, Marie Rossignol, Carole Ginibre, Vasileia Balabanidou, Natacha Garcia Albeniz Mendez, Olivier Pigeon, John Vontas, Sylvie Cornelie
Contributions of cuticle permeability and enzyme detoxification to pyrethroid resistance in the major malaria vector Anopheles gambiae
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-11357-z
Scientific Reports 7/1 2020-03-23
2018 Sebastián Napp, Dusan Petrić, Núria Busquets
West Nile virus and other mosquito-borne viruses present in Eastern Europe
published pages: 1-16, ISSN: 2047-7724, DOI: 10.1080/20477724.2018.1483567
Pathogens and Global Health 2020-03-23
2018 Marie Miglianico, Maarten Eldering, Hannah Slater, Neil Ferguson, Pauline Ambrose, Rosemary S. Lees, Karin M. J. Koolen, Katerina Pruzinova, Magdalena Jancarova, Petr Volf, Constantianus J. M. Koenraadt, Hans-Peter Duerr, Graham Trevitt, Baiyuan Yang, Arnab K. Chatterjee, John Wisler, Angelika Sturm, Teun Bousema, Robert W. Sauerwein, Peter G. Schultz, Matthew S. Tremblay, Koen J. Dechering
Repurposing isoxazoline veterinary drugs for control of vector-borne human diseases
published pages: E6920-E6926, ISSN: 0027-8424, DOI: 10.1073/pnas.1801338115
Proceedings of the National Academy of Sciences 115/29 2020-03-23
2017 Michelle M Riehle, Tullu Bukhari, Awa Gneme, Wamdaogo M Guelbeogo, Boubacar Coulibaly, Abdrahamane Fofana, Adrien Pain, Emmanuel Bischoff, Francois Renaud, Abdoul H Beavogui, Sekou F Traore, N’Fale Sagnon, Kenneth D Vernick
The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.25813
eLife 6 2020-03-23
2016 Alain Kohl, Emilie Pondeville, Esther Schnettler, Andrea Crisanti, Clelia Supparo, George K. Christophides, Paul J. Kersey, Gareth L. Maslen, Willem Takken, Constantianus J. M. Koenraadt, Clelia F. Oliva, Núria Busquets, F. Xavier Abad, Anna-Bella Failloux, Elena A. Levashina, Anthony J. Wilson, Eva Veronesi, Maëlle Pichard, Sarah Arnaud Marsh, Frédéric Simard, Kenneth D. Vernick
Advancing vector biology research: a community survey for future directions, research applications and infrastructure requirements
published pages: 164-172, ISSN: 2047-7724, DOI: 10.1080/20477724.2016.1211475
Pathogens and Global Health 110/4-5 2020-03-23
2017 Paul Julian Kersey, James E Allen, Alexis Allot, Matthieu Barba, Sanjay Boddu, Bruce J Bolt, Denise Carvalho-Silva, Mikkel Christensen, Paul Davis, Christoph Grabmueller, Navin Kumar, Zicheng Liu, Thomas Maurel, Ben Moore, Mark D McDowall, Uma Maheswari, Guy Naamati, Victoria Newman, Chuang Kee Ong, Michael Paulini, Helder Pedro, Emily Perry, Matthew Russell, Helen Sparrow, Electra Tapanari, Kieron Taylor, Alessandro Vullo, Gareth Williams, Amonida Zadissia, Andrew Olson, Joshua Stein, Sharon Wei, Marcela Tello-Ruiz, Doreen Ware, Aurelien Luciani, Simon Potter, Robert D Finn, Martin Urban, Kim E Hammond-Kosack, Dan M Bolser, Nishadi De Silva, Kevin L Howe, Nicholas Langridge, Gareth Maslen, Daniel Michael Staines, Andrew Yates
Ensembl Genomes 2018: an integrated omics infrastructure for non-vertebrate species
published pages: D802-D808, ISSN: 0305-1048, DOI: 10.1093/nar/gkx1011
Nucleic Acids Research 46/D1 2020-03-23
2017 Eugeni Belda, Boubacar Coulibaly, Abdrahamane Fofana, Abdoul H. Beavogui, Sekou F. Traore, Daryl M. Gohl, Kenneth D. Vernick, Michelle M. Riehle
Preferential suppression of Anopheles gambiae host sequences allows detection of the mosquito eukaryotic microbiome
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-03487-1
Scientific Reports 7/1 2020-03-23
2018 Ferdinand Nanfack Minkeu, Kenneth Vernick
A Systematic Review of the Natural Virome of Anopheles Mosquitoes
published pages: 222, ISSN: 1999-4915, DOI: 10.3390/v10050222
Viruses 10/5 2020-03-23
2017 Linda Grigoraki, Arianna Puggioli, Konstantinos Mavridis, Vassilis Douris, Mario Montanari, Romeo Bellini, John Vontas
Striking diflubenzuron resistance in Culex pipiens, the prime vector of West Nile Virus
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-12103-1
Scientific Reports 7/1 2020-03-23
2018 Guillaume Carissimo, Adrien Pain, Eugeni Belda, Kenneth D. Vernick
Highly focused transcriptional response of Anopheles coluzzii to O’nyong nyong arbovirus during the primary midgut infection
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-018-4918-0
BMC Genomics 19/1 2020-03-23
2017 Kenneth D. Vernick
Infravec2: expanding researcher access to insect vector tools and resources
published pages: 1-2, ISSN: 2047-7724, DOI: 10.1080/20477724.2017.1347079
Pathogens and Global Health 2020-03-23

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