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MITOSENSING SIGNED

Decoding mitochondrial nutrient-sensing programs in POMC neurons as key determinants of metabolic health

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MITOSENSING project word cloud

Explore the words cloud of the MITOSENSING project. It provides you a very rough idea of what is the project "MITOSENSING" about.

systemic nutritional disorders pursue regulatory functional scientific defects mechanisms lifestyle hypothesizes sense balance effectors implications engage primary energy diabetes homeostasis functions strategies networks signals neuroendocrine modulated physiological actions monitor neurons entity bioenergetic underlie lacking sensors mitochondria molecular mitosensing neuron caused integrate logical organism obesity metabolic sources programs play gene coordinate sensing vivo mitochondrial neuronal commanders critical modulators disruption adaptive enormous sustain status governing behavioural central t2d therapeutical defective cellular pomc milieu context life alterations mechanistic nutrient integrative subset transcriptionally candidates

Project "MITOSENSING" data sheet

The following table provides information about the project.

Coordinator	CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Organization address address: CALLE ROSSELLO 149 PUERTA BJS city: BARCELONA postcode: 8036 website: http://www.idibaps.org/en_index.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	1˙999˙573 €
EC max contribution	1˙999˙573 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-COG
Funding Scheme	ERC-COG
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2022-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER Organization address address: CALLE ROSSELLO 149 PUERTA BJS city: BARCELONA postcode: 8036 website: http://www.idibaps.org/en_index.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	coordinator	1˙999˙573.00

Map

Project objective

Nutrient-sensing by POMC neurons is a critical process to monitor the metabolic status of the organism and to coordinate adaptive neuroendocrine, behavioural and metabolic effectors of energy balance. Mitochondria, as central commanders of cellular energy production and primary sources of bioenergetic signals, are logical candidates to play a key role in metabolic control. However, a comprehensive understanding of the mitochondria as nutrient-sensors and modulators of systemic energy homeostasis is lacking. MITOSENSING hypothesizes that dedicated mitochondrial networks in POMC neurons are able to sense, integrate and respond to alterations in the nutritional milieu and engage physiological actions to maintain energy balance. Thus, defects in these mitochondrial nutrient-sensing programs in this subset of neurons underlie the development of metabolic conditions such as obesity and type-2 diabetes (T2D). To test it, we will pursue three aims: 1) to identify transcriptionally-modulated mitochondrial nutrient-sensing programs in POMC neurons; 2) to investigate whether disruption of specific nutrient-sensing programs in POMC neurons cause metabolic disorders; 3) to investigate whether the development of lifestyle-associated metabolic disorders are caused by defective mitochondrial nutrient-sensing programs in POMC neurons. By providing neuron-specific, integrative, functional and mechanistic in vivo strategies, MITOSENSING will represent a major step forward into the understanding of mitochondria as a nutrient-sensing entity, the gene programs involved and their physiological regulatory functions in the context of energy balance control. Adequate coordination of neuronal nutrient-sensing with energy balance control is critical to sustain life, and thus understanding the molecular mechanisms governing these physiological programs will have an enormous scientific impact and also potential therapeutical implications for obesity and T2D.

Publications

List of publications.
year	authors and title	journal	last update
2018	Macarena Pozo, Marc Claret Hypothalamic Control of Systemic Glucose Homeostasis: The Pancreas Connection published pages: 581-594, ISSN: 1043-2760, DOI: 10.1016/j.tem.2018.05.001	Trends in Endocrinology & Metabolism 29/8	2019-05-06

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