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DyNAmics

Dynamic synthetic molecular duplexes

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

DyNAmics project word cloud

Explore the words cloud of the DyNAmics project. It provides you a very rough idea of what is the project "DyNAmics" about.

appropriate biological structure intermolecular enzyme biggest modular combinatorial dynamics dna supramolecular efficient fascinating robustness smart chemistry perform unprecedented sequences chemical modern multivalent template quantitative accomplishes synthetic structural questions adding molecular molecules duplexes constitutional components assembly bond nonliving materials defective deeply deep organizes interactions free valuable self innovative precise covalent macroscopic storage nature answer complementary prebiotic living science flexible organize reliability manipulation duplex lay regarding bonds directed monomers fidelity recognition transformation dynamic inspired encoding word synthesis imperfections data foundation

Project "DyNAmics" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www-hunter.ch.cam.ac.uk
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-03-01 to 2019-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	183˙454.00

Map

Project objective

Precise control of macroscopic properties at molecular level is one of the biggest challenges of modern science. Nature accomplishes this by adding information to matter, and organizes chemical system of nonliving components into living, biological systems. Achieving a deep knowledge on the appropriate manipulation of the intermolecular non-covalent interactions, will allow chemistry to be not only the science of the structure and transformation of matter, but also an information science, involving the storage of information at the molecular level. Inspired by the most fascinating nature’s information system, the DNA, “DyNAmics” will perform a modular and highly flexible synthesis of novel information carrying monomers, able to self-organize in duplex structure, through both covalent and non-covalent bonds formation. The reliability, robustness and the dynamic formation of H-bond based duplex, together with the template ability in a dynamic combinatorial system, will be deeply investigated. By quantitative assessment of multivalent recognition of complementary sequences and imperfections in the duplex formation of non-complementary and defective sequences, valuable information on the structural features and fidelity of supramolecular assembly formation of various sequences will be obtained. Reliable formation of dynamic synthetic duplexes would allow precise control over supramolecular interactions and will lay the foundation for formation of smart advanced materials with unprecedented properties, such as innovative data storage materials and new Constitutional Dynamic Materials. Furthermore this will be crucial for the development of efficient template directed synthesis for information encoding molecules, and it will provide information to answer to important questions regarding the formation of duplex encoding information, in a enzyme free system, such as the prebiotic word.

Publications

List of publications.
year	authors and title	journal	last update
2019	SzczypiÅ„ski, Filip; Gabrielli, Luca; Hunter, Christopher Emergent Supramolecular Assembly Properties of a Recognition-Encoded Oligoester published pages: , ISSN: 2041-6520, DOI:	Chemical Science	2019-09-02

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The information about "DYNAMICS" are provided by the European Opendata Portal: CORDIS opendata.