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ProFrost SIGNED

Theoretical and Numerical Analysis of Antifreeze and Ice Nucleator Proteins:Coarse-Grain Approach for Multiscale Study and Bio-Engineering

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 ProFrost project word cloud

Explore the words cloud of the ProFrost project. It provides you a very rough idea of what is the project "ProFrost" about.

folding    computer    solutions    disciplines    academy    model    rate    search    explore    food    preservation    life    shelf    sequences    carlos    vega    theoretical    subject    pave    framework    tissues    deeply    supervision    technological    physical    offers    broad    prof    protein    environmental    influencing    water    dellago    nucleator    attracts    dr    multiple    point    scientific    simulations    publications    line    influence    adapt    biophysical    artificial    combines    follows    letters    dynamical    character    ice    functionalized    temperatures    spectrum    review    biology    coarse    nature    proceeding    international    expert    science    profrost    coluzza    combination    chemistry    grain    molecules    understand    structural    antifreeze    inps    cryo    thermodynamic    physics    journals    space    national    interfaces    afps    innovative    atmospheric    proteins    frozen    excursions    configurational    bio    pressures    organisms    interdisciplinary    nucleation   

Project "ProFrost" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD COMPLUTENSE DE MADRID 

Organization address
address: AVENIDA DE SENECA 2
city: MADRID
postcode: 28040
website: http://www.ucm.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD COMPLUTENSE DE MADRID ES (MADRID) coordinator 158˙121.00

Map

 Project objective

In nature there are many organisms able to control the ice nucleation rate of water. This ability allows such organisms to adapt to environmental changes, like large temperatures excursions, and to facilitate the search for food. Bio-molecules such as antifreeze proteins (AFPs) and ice nucleator proteins (INPs) are known to influence the ice nucleation rate, a feature that attracts great interest from a wide spectrum of scientific disciplines like biology and atmospheric science, and it offers several technological applications like cryo-preservation of tissues and increasing frozen food shelf life. I propose a new approach, based on a novel combination of water-protein coarse-grain model, able, for a wide range of temperatures and pressures, to deeply explore the configurational space of a water-protein solutions. The ProFrost project aims at defining a novel theoretical framework within which it will be possible to study how the folding properties of AFPs and INPs affect the thermodynamic state point of water. The main goal of the project is to understand the influence of protein interfaces on the dynamical and structural properties of water. The success of this project will pave the way for the computer based design of artificial functionalized protein sequences capable of influencing the phase of water. This project follows an innovative research line, with a multi-scale approach that combines multiple fields of research, such as physics, biology and chemistry. This research due to its interdisciplinary character and broad interest, has large impact and is often subject of publications on relevant international scientific journals, such as Nature, Science, Proceeding of National Academy of Science, Physical Review Letters. ProFrost will carried out under the supervision Prof Carlos Vega, a leading expert on water, and in collaboration with Prof. Dellago and Dr. Coluzza, expert in modelling and simulations of biophysical systems,

 Publications

year authors and title journal last update
List of publications.
2018 Valentino Bianco, Emanuele Locatelli, Paolo Malgaretti
Globulelike Conformation and Enhanced Diffusion of Active Polymers
published pages: , ISSN: 0031-9007, DOI: 10.1103/physrevlett.121.217802
Physical Review Letters 121/21 2019-07-18

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