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IAPEMIDE

Impact of Intrapartum Antimicrobial Prophylaxis as an early determinant in Microbiome Development

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

IAPEMIDE project word cloud

Explore the words cloud of the IAPEMIDE project. It provides you a very rough idea of what is the project "IAPEMIDE" about.

mandatory diseases communicable resistance protective rising western minimising establishment antimicrobial reducing consequence strategies iap foetus antibiotic milk opportunity last treatment mechanisms placenta quality continue later during disease care breast situations neonatal administration career doctors infant once least adult evident decades genes spectrum intestinal antibiotics health 11 alterations total maternal childhood urgent orchestrating lifestyle modulation risk relationship 30 intrapartum microbiota life countries strengthen broad besides beginning resistome worthy resistances first diet im worries cross dietary plays recommendations exerts feeding prophylaxis chronic extremely adverse types competences negative correct regarding deliveries decisions

Project "IAPEMIDE" data sheet

The following table provides information about the project.

Coordinator	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.ipla.csic.es/microbiota-alimentacion-y-salud
Total cost	158˙121 €
EC max contribution	158˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-08-01 to 2019-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	158˙121.00

Map

Project objective

During the last decades, changes in diet and lifestyle have increased the risk of non-communicable diseases in the western countries. It is known that once they are established in the childhood, they continue into adult life with the associated negative impact on health, quality of life and health care costs. The correct establishment of the intestinal microbiota (IM) at the beginning of life plays a key role in health, reducing risk of chronic disease. Some factors affecting this process have been studied; however, other like the intrapartum antimicrobial prophylaxis (IAP), in spite of been present on over 30% of total deliveries, have been much less studied. It is already known that at least 11 types of broad-spectrum antibiotics cross the placenta and reach the foetus. Given the increasingly evident relationship between early microbiota, later disease risk and the rising worries regarding antimicrobial resistances, there is an urgent need to assess the potential adverse consequences of IAP in the establishment of the IM and resistome. This project will be the first to study mechanisms orchestrating the impact of IAP on the neonatal IM establishment. The objectives are: identify the alterations induced by IAP in the neonatal IM development; identify the antibiotic resistance genes that the IM carried as consequence of IAP; study the potential role of infant feeding in the modulation of the microbiota after IAP administration and design of specific dietary strategies for minimising the impact of IAP on the IM establishment. Moreover, if the breast-milk exerts a protective role, it would help to strengthen the maternal breast-feeding recommendations. Following this study, doctors will be better able to address the consequences to make knowledge-based decisions about IAP treatment in those situations where it is not extremely mandatory. Besides, the present project will represent a worthy opportunity for the applicant to improve her research competences and career.

Publications

List of publications.
year	authors and title	journal	last update
2018	- G. SolÃs, M. SuÃ¡rez, N. FernÃ¡ndez, L. MantecÃ³n, S. Arboleya, A. Nogacka, C. Milani, C.G. de los Reyes-GavilÃ¡n, M. Ventura, M. Gueimonde Metagenomics analysis disclose the impact of intrapartum antimicrobial prophylaxis in the early microbiome published pages: , ISSN: , DOI:	J Pediatr Neonat Individual Med	2019-11-20
2018	Silvia Arboleya, M. SuÃ¡rez, N. FernÃ¡ndez, L. MantecÃ³n, G. SolÃs, M. Gueimonde, C.G. deÂ losÂ Reyes-GavilÃ¡n C-section and the Neonatal Gut Microbiome Acquisition: Consequences for Future Health published pages: 17-23, ISSN: 0250-6807, DOI: 10.1159/000490843	Annals of Nutrition and Metabolism 73/3	2019-11-20
2018	- G. SolÃs, S. Arboleya, M. SuÃ¡rez, N. FernÃ¡ndez, L. MantecÃ³n, A. Nogacka, C. Milani, C.G. de los Reyes-GavilÃ¡n, M. Ventura, M. Gueimonde Intrapartum antimicrobial prophylaxis affects early-gut Bifidobacterium populations in healthy neonates published pages: , ISSN: , DOI: 10.7363/070232	Journal of Pediatric and Neonatal Individualized Medicine (JPNIM)	2019-11-20
2019	Saturio S., Nogacka A., FernÃ¡ndez N., SuÃ¡rez M., SolÃs G., de los Reyes-GavilÃ¡n C.G., Gueimonde M., Arboleya S Abstracts of the 10th Workshop on Probiotics and Prebiotics published pages: 1-31, ISSN: 0250-6807, DOI: 10.1159/000496759	Annals of Nutrition and Metabolism 74/Suppl. 1	2019-11-20

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The information about "IAPEMIDE" are provided by the European Opendata Portal: CORDIS opendata.