IAPEMIDE
Impact of Intrapartum Antimicrobial Prophylaxis as an early determinant in Microbiome Development
Total Cost €
0EC-Contrib. €
0Partnership
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Project "IAPEMIDE" data sheet
The following table provides information about the project.
| Coordinator |
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Project website | http://www.ipla.csic.es/microbiota-alimentacion-y-salud |
| Total cost | 158˙121 € |
| EC max contribution | 158˙121 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2016 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-08-01 to 2019-07-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS | ES (MADRID) | coordinator | 158˙121.00 |
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Project objective
During the last decades, changes in diet and lifestyle have increased the risk of non-communicable diseases in the western countries. It is known that once they are established in the childhood, they continue into adult life with the associated negative impact on health, quality of life and health care costs. The correct establishment of the intestinal microbiota (IM) at the beginning of life plays a key role in health, reducing risk of chronic disease. Some factors affecting this process have been studied; however, other like the intrapartum antimicrobial prophylaxis (IAP), in spite of been present on over 30% of total deliveries, have been much less studied. It is already known that at least 11 types of broad-spectrum antibiotics cross the placenta and reach the foetus. Given the increasingly evident relationship between early microbiota, later disease risk and the rising worries regarding antimicrobial resistances, there is an urgent need to assess the potential adverse consequences of IAP in the establishment of the IM and resistome. This project will be the first to study mechanisms orchestrating the impact of IAP on the neonatal IM establishment. The objectives are: identify the alterations induced by IAP in the neonatal IM development; identify the antibiotic resistance genes that the IM carried as consequence of IAP; study the potential role of infant feeding in the modulation of the microbiota after IAP administration and design of specific dietary strategies for minimising the impact of IAP on the IM establishment. Moreover, if the breast-milk exerts a protective role, it would help to strengthen the maternal breast-feeding recommendations. Following this study, doctors will be better able to address the consequences to make knowledge-based decisions about IAP treatment in those situations where it is not extremely mandatory. Besides, the present project will represent a worthy opportunity for the applicant to improve her research competences and career.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
- G. SolÃs, M. Suárez, N. Fernández, L. Mantecón, S. Arboleya, A. Nogacka, C. Milani, C.G. de los Reyes-Gavilán, M. Ventura, M. Gueimonde Metagenomics analysis disclose the impact of intrapartum antimicrobial prophylaxis in the early microbiome published pages: , ISSN: , DOI: |
J Pediatr Neonat Individual Med | 2019-11-20 |
| 2018 |
Silvia Arboleya, M. Suárez, N. Fernández, L. Mantecón, G. SolÃs, M. Gueimonde, C.G. de los Reyes-Gavilán C-section and the Neonatal Gut Microbiome Acquisition: Consequences for Future Health published pages: 17-23, ISSN: 0250-6807, DOI: 10.1159/000490843 |
Annals of Nutrition and Metabolism 73/3 | 2019-11-20 |
| 2018 |
- G. SolÃs, S. Arboleya, M. Suárez, N. Fernández, L. Mantecón, A. Nogacka, C. Milani, C.G. de los Reyes-Gavilán, M. Ventura, M. Gueimonde Intrapartum antimicrobial prophylaxis affects early-gut Bifidobacterium populations in healthy neonates published pages: , ISSN: , DOI: 10.7363/070232 |
Journal of Pediatric and Neonatal Individualized Medicine (JPNIM) | 2019-11-20 |
| 2019 |
Saturio S., Nogacka A., Fernández N., Suárez M., SolÃs G., de los Reyes-Gavilán C.G., Gueimonde M., Arboleya S Abstracts of the 10th Workshop on Probiotics and Prebiotics published pages: 1-31, ISSN: 0250-6807, DOI: 10.1159/000496759 |
Annals of Nutrition and Metabolism 74/Suppl. 1 | 2019-11-20 |
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