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ECtomics SIGNED

Dissecting spinal cord ependymal cell heterogeneity by single-cell transcriptomics

Total Cost €

EC-Contrib. €

Partnership

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ECtomics project word cloud

Explore the words cloud of the ECtomics project. It provides you a very rough idea of what is the project "ECtomics" about.

fundamental adult mammalian ependymal ecs pseudotemporal generate progeny characterisation localised individual ec elucidate first computational relationships renewing heterogeneous neural markers handful obtain single rna mice self transcriptomes morphological sequencing therapeutic molecular confocal resolution cord edge stem types expression purposes tissue spinal uncover heterogeneity specialised lineage realisation exist cellular advantage insights cells population renew context validate possess interdisciplinary cell cutting microscopy

Project "ECtomics" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF DUNDEE Organization address address: Nethergate city: DUNDEE postcode: DD1 4HN website: www.dundee.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2019-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF DUNDEE UNIVERSITY OF DUNDEE Organization address address: Nethergate city: DUNDEE postcode: DD1 4HN website: www.dundee.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (DUNDEE)	coordinator	183˙454.00

Map

Project objective

Cells with stem cell potential, this is with the ability to self-renew and generate specialised progeny, exist in the adult mammalian spinal cord. Previous studies localised this potential within the ependymal cell (EC) population. However, ECs are rather heterogeneous based on their morphological features and the expression of a handful of neural stem cell markers. In this interdisciplinary research proposal, I aim to uncover the cellular and molecular heterogeneity of ECs at the level of individual cells. I propose to take advantage of cutting-edge single-cell RNA-sequencing technology to obtain the transcriptomes of individual ECs from the spinal cord of adult mice. Using advanced computational methods, I will establish EC types and states and use pseudotemporal ordering to elucidate potential lineage relationships among ECs. I will then validate these findings in the tissue context, using high-resolution confocal microscopy. This first comprehensive characterisation of spinal cord ECs will provide novel and fundamental insights into how ECs possess and maintain their unique self-renewing properties. In the future, this will facilitate realisation of the potential of spinal cord stem cells for therapeutic purposes.

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The information about "ECTOMICS" are provided by the European Opendata Portal: CORDIS opendata.