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PRISM SIGNED

Psychiatric Ratings using Intermediate Stratified Markers - Sofia ref.: 115916

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PRISM project word cloud

Explore the words cloud of the PRISM project. It provides you a very rough idea of what is the project "PRISM" about.

decades treatments treatment epi innovative certain combined biological data nosology monitoring md differentiate academic instance exhibit quantifiable tested dramatically deficits share cluster relationships proxy ad memory disorders individuals smes datasets global predict discovery accelerate diseases concentrate cohort encompassing engaged regulation deep ecnp depression quantitative cognitive disease genetics experts first lower coordinated patient patients technologies socially neuropsychiatric drug cohorts social withdrawn stagnated phenotypic eeg classification efpia schizophrenia phenotype levels regulators withdrawal symptomatology functioning mining course mri rationale pragmatic exploration alzheimer poorer sz clinical obtaining effort family sensory smartphone

Project "PRISM" data sheet

The following table provides information about the project.

Coordinator	RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://prism-project.eu
Total cost	16˙195˙875 €
EC max contribution	8˙080˙000 € (50%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2015-03-two-stage
Funding Scheme	IMI2-RIA
Starting year	2016
Duration (year-month-day)	from 2016-04-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	coordinator	2˙105˙481.00
2	P1VITAL LIMITED P1VITAL LIMITED Organization address address: MANOR HOUSE HOWBERY PARK city: WALLINGFORD postcode: OX10 8BA website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (WALLINGFORD)	participant	1˙226˙586.00
3	STICHTING KATHOLIEKE UNIVERSITEIT STICHTING KATHOLIEKE UNIVERSITEIT Organization address address: GEERT GROOTEPLEIN NOORD 9 city: NIJMEGEN postcode: 6525 EZ website: www.radboudumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	840˙250.00
4	STICHTING VUMC STICHTING VUMC Organization address address: DE BOELELAAN 1117 city: AMSTERDAM postcode: 1081 HV website: www.vumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	775˙000.00
5	CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P. CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P. Organization address address: CALLE MONFORTE DE LEMOS 5 city: MADRID postcode: 28029 website: www.ciberisciii.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	678˙450.00
6	SBGNEURO LTD SBGNEURO LTD Organization address address: 6A ST ANDREWS COURT WELLINGTON STR city: THAME postcode: OX9 3WT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (THAME)	participant	490˙500.00
7	BIOTRIAL BIOTRIAL Organization address address: RUE JEAN-LOUIS BERTRAND 7 - 9 city: RENNES postcode: 35042 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (RENNES)	participant	350˙000.00
8	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	334˙775.00
9	Concentris Research Management GmbH Concentris Research Management GmbH Organization address address: Ludwigstr. 4 city: Fürstenfeldbruck postcode: D-82256 website: www.concentris.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Fürstenfeldbruck)	participant	315˙000.00
10	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	286˙644.00
11	DRUG TARGET ID BV DRUG TARGET ID BV Organization address address: TOERNOOIVELD 200 city: NIJMEGEN postcode: 6525 EC website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	participant	200˙250.00
12	STICHTING BURO ECNP STICHTING BURO ECNP Organization address address: BOLOGNALAAN 28 city: UTRECHT postcode: 3584 CJ website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	168˙500.00
13	ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Organization address address: VIA ZAMBONI 33 city: BOLOGNA postcode: 40126 website: www.unibo.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (BOLOGNA)	participant	100˙000.00
14	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	100˙000.00
15	THE UNIVERSITY OF EXETER THE UNIVERSITY OF EXETER Organization address address: THE QUEEN'S DRIVE NORTHCOTE HOUSE city: EXETER postcode: EX4 4QJ website: www.ex.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EXETER)	participant	90˙000.00
16	EUROPESE FEDERATIE VAN FAMILIEVERENIGINGEN VAN PSYCHIATRISCH ZIEKE PERSONEN IVZW EUROPESE FEDERATIE VAN FAMILIEVERENIGINGEN VAN PSYCHIATRISCH ZIEKE PERSONEN IVZW Organization address address: DIESTSEVEST 100 city: LEUVEN postcode: 3000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	18˙563.00
17	BOEHRINGER INGELHEIM INTERNATIONALGMBH BOEHRINGER INGELHEIM INTERNATIONALGMBH Organization address address: BINGER STRASSE city: INGELHEIM postcode: 55218 website: www.boehringerâ€ingelheim.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (INGELHEIM)	participant	0.00
18	Eli Lilly and Company Limited Eli Lilly and Company Limited Organization address address: Lilly House, Priestley Road city: Basingstoke postcode: RG24 9NL website: www.lilly.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Basingstoke)	participant	0.00
19	F. HOFFMANN-LA ROCHE AG F. HOFFMANN-LA ROCHE AG Organization address address: GRENZACHERSTRASSE 124 city: BASEL postcode: 4070 website: www.roche.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00
20	JANSSEN PHARMACEUTICA NV JANSSEN PHARMACEUTICA NV Organization address address: TURNHOUTSEWEG 30 city: BEERSE postcode: 2340 website: www.janssenpharmaceutica.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BEERSE)	participant	0.00
21	NOVARTIS PHARMA AG NOVARTIS PHARMA AG Organization address address: LICHTSTRASSE 35 city: BASEL postcode: 4056 website: www.novartis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BASEL)	participant	0.00
22	PFIZER LIMITED PFIZER LIMITED Organization address address: RAMSGATE ROAD city: SANDWICH postcode: CT13 9NJ website: www.pfizer.co.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SANDWICH)	participant	0.00
23	TAKEDA DEVELOPMENT CENTRE EUROPE LTD TAKEDA DEVELOPMENT CENTRE EUROPE LTD Organization address address: ALDWYCH 61 city: LONDON postcode: WC2B 4AE website: www.takeda.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	0.00

Map

Project objective

The current nosology of neuropsychiatric disorders allows for a pragmatic approach to treatment choice, regulation and clinical research. However, without a biological rationale for these disorders, drug development has dramatically stagnated in the past decades. In a coordinated effort encompassing academic experts, SMEs, patient and family organizations, regulators, ECNP and EFPIA partners, this project aims to develop a quantitative biological approach to the understanding and classification of neuropsychiatric diseases to accelerate the discovery and development of better treatments for patients. This project will concentrate on Schizophrenia (SZ), Alzheimer’s disease (AD), and Major Depression (MD), as these disorders share part of their symptomatology, in particular social withdrawal and certain cognitive deficits, such as deficits in attention, working memory and sensory processing. By applying innovative technologies (e.g. EEG, cognitive tasks, (f)MRI, smartphone monitoring, and (epi-)genetics) to deep phenotype a clinical cohort of SZ and AD patients combined with a wider analysis of existing clinical data sets from major European and global disease cohorts that also include MD, we will define a set of quantifiable biological parameters best able to cluster and differentiate SZ, AD, and MD patients that do, or do not, exhibit social withdrawal. First, by mining large European SZ, AD and MD cohort datasets with already available social and cognitive proxy measures, and, second, by obtaining objective measures of social exploration levels (using a novel smartphone application), phenotypic relationships with social and cognitive measures will be further tested. For instance we might predict that socially withdrawn individuals may have lower cognitive functioning and poorer clinical course compared to those who are more socially engaged.

Deliverables

List of deliverables.
Final press release	Documents, reports	2020-04-08 20:57:19
Consensus report on pragmatic and ecological outcomes that will increase functionality and quality of life of those affected by the disorders studied published as a point of view paper in a scientific journal.	Documents, reports	2020-04-08 20:57:19
Validation report on proxy indicators for cognitive deficits in patient cohorts.	Documents, reports	2020-04-08 20:57:19
Presentation of PRISM findings to patients and their families	Websites, patent fillings, videos etc.	2020-04-08 20:57:19
PRISM Communication material ready (leaflet, slides)	Websites, patent fillings, videos etc.	2020-04-08 20:57:18
First quarterly electronic bulletins online	Websites, patent fillings, videos etc.	2020-04-08 20:57:18
First press release	Websites, patent fillings, videos etc.	2020-04-08 20:57:18
Manuscript submission of review article on the selection of phenotyping methods	Documents, reports	2020-04-08 20:57:18
Final protocol	Documents, reports	2020-04-08 20:57:18
Social withdrawal SOP disseminated to WP6 partners and workshop held	Documents, reports	2020-04-08 20:57:18
Report on pre-selection of study designs, instruments and methodology for clinical and pre-clinical deep phenotyping	Documents, reports	2020-04-08 20:57:18
Consensus framework document on final selection of study designs, instruments and methodology for clinical and pre- clinical deep phenotyping	Documents, reports	2020-04-08 20:57:18
Go-online of the public project website	Websites, patent fillings, videos etc.	2020-04-08 20:57:18
Data Management Plan	Documents, reports	2020-04-08 20:57:18
Consensus framework document on selection of tools and instruments, and inclusion/exclusion criteria for clinical deep phenotyping	Documents, reports	2020-04-08 20:57:18

Take a look to the deliverables list in detail: detailed list of PRISM deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Raphaelle Winsky-Sommerer, Paula de Oliveira, Sally Loomis, Keith Wafford, Derk-Jan Dijk, Gary Gilmour Disturbances of sleep quality, timing and structure and their relationship with other neuropsychiatric symptoms in Alzheimerâ€™s disease and schizophrenia: Insights from studies in patient populations and animal models published pages: 112-137, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.09.027	Neuroscience & Biobehavioral Reviews 97	2020-04-08
2019	J Bralten, CJHM Klemann, NR Mota, W De Witte, C Arango, C Fabbri, MJ Kas, N van der Wee, BWJH Penninx, A Serretti, B Franke, G Poelmans Genetic underpinnings of sociability in the UK Biobank published pages: , ISSN: , DOI:		2020-04-08
2018	Johnny Downs, Harry Dean, Suzannah Lechler, Nicola Sears, Rashmi Patel, Hitesh Shetty, Matthew Hotopf, Tamsin Ford, Marinos Kyriakopoulos, Covadonga M Diaz-Caneja, Celso Arango, James H MacCabe, Richard D Hayes, Laura Pina-Camacho Negative Symptoms in Early-Onset Psychosis and Their Association With Antipsychotic Treatment Failure published pages: 69-79, ISSN: 0586-7614, DOI: 10.1093/schbul/sbx197	Schizophrenia Bulletin 45/1	2020-04-08
2019	P. Danjou, G. Viardot, D. Maurice, P. GarcÃ©s, E.J. Wams, K.G. Phillips, V. Bertaina-Anglade, A.P. McCarthy, D.J. Pemberton Electrophysiological assessment methodology of sensory processing dysfunction in schizophrenia and dementia of the Alzheimer type published pages: 70-84, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.09.004	Neuroscience & Biobehavioral Reviews 97	2020-04-08
2019	Stefano Porcelli, Nic Van Der Wee, Steven van der Werff, Moji Aghajani, Jeffrey C. Glennon, Sabrina van Heukelum, Floriana Mogavero, Antonio Lobo, Francisco Javier Olivera, Elena Lobo, Mar Posadas, Juergen Dukart, Rouba Kozak, Estibaliz Arce, Arfan Ikram, Jacob Vorstman, Amy Bilderbeck, Ilja Saris, Martien J. Kas, Alessandro Serretti Social brain, social dysfunction and social withdrawal published pages: 10-33, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.09.012	Neuroscience & Biobehavioral Reviews 97	2020-04-08
2019	Martien J. Kas, Alessandro Serretti, Hugh Marston Quantitative neurosymptomatics: Linking quantitative biology to neuropsychiatry published pages: 1-2, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.11.013	Neuroscience & Biobehavioral Reviews 97	2020-04-08
2019	Tatiana Peleh, Xuesheng Bai, Martien J.H. Kas, Bastian Hengerer RFID-supported video tracking for automated analysis of social behaviour in groups of mice published pages: 108323, ISSN: 0165-0270, DOI: 10.1016/j.jneumeth.2019.108323	Journal of Neuroscience Methods 325	2020-04-08
2019	Nic. J.A. van der Wee, Amy C. Bilderbeck, Maria Cabello, Jose L. Ayuso-Mateos, Ilja M.J. Saris, Erik J. Giltay, Brenda W.J.H. Penninx, Celso Arango, Anke Post, Stefano Porcelli Working definitions, subjective and objective assessments and experimental paradigms in a study exploring social withdrawal in schizophrenia and Alzheimerâ€™s disease published pages: 38-46, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.06.020	Neuroscience & Biobehavioral Reviews 97	2020-04-08
2019	Gary Gilmour, Stefano Porcelli, ValÃ©rie Bertaina-Anglade, Estibaliz Arce, Juergen Dukart, Anja Hayen, Antonio Lobo, Raul Lopez-Anton, Emilio Merlo Pich, Darrel J. Pemberton, Martha N. Havenith, Jeffrey C. Glennon, Brian T. Harel, Gerard Dawson, Hugh Marston, Rouba Kozak, Alessandro Serretti Relating constructs of attention and working memory to social withdrawal in Alzheimerâ€™s disease and schizophrenia: issues regarding paradigm selection published pages: 47-69, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.09.025	Neuroscience & Biobehavioral Reviews 97	2020-04-08
2019	Amy C. Bilderbeck, Brenda W.J.H. Penninx, Celso Arango, Nic van der Wee, RenÃ© Kahn, Inge Winter-van Rossum, Anja Hayen, Martien J. Kas, Anke Post, Gerard R. Dawson Overview of the clinical implementation of a study exploring social withdrawal in patients with schizophrenia and Alzheimerâ€™s disease published pages: 87-93, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.06.019	Neuroscience & Biobehavioral Reviews 97	2020-04-08
2018	Maria Bove, Kevin Ike, Adriaan Eldering, Bauke Buwalda, Sietse F. de Boer, Maria Grazia Morgese, Stefania Schiavone, Vincenzo Cuomo, Luigia Trabace, Martien J.H. Kas The Visible Burrow System: A behavioral paradigm to assess sociability and social withdrawal in BTBR and C57BL/6J mice strains published pages: 9-19, ISSN: 0166-4328, DOI: 10.1016/j.bbr.2018.02.003	Behavioural Brain Research 344	2020-04-08
2018	Betty E. Hornix, Robbert Havekes, Martien J.H. Kas Multisensory cortical processing and dysfunction across the neuropsychiatric spectrum published pages: pending, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2018.02.010	Neuroscience & Biobehavioral Reviews 2018 Feb 26. pii: S0149-7634(17	2020-04-08
2017	Hugh Marston Depression, schizophrenia may become redundant terms published pages: N/A, ISSN: , DOI:	Horizon Magazine N/A	2020-04-08
2017	Hugh Marston The PRISM project - measuring quantitative biology published pages: N/A, ISSN: , DOI:	Big Data in Neurophysiology N/A	2020-04-08
2017	Julia H. Harari, Covadonga M. DÃaz-Caneja, Joost Janssen, Kenia MartÃnez, BÃ¡rbara Arias, Celso Arango The association between gene variants and longitudinal structural brain changes in psychosis: a systematic review of longitudinal neuroimaging genetics studies published pages: , ISSN: 2334-265X, DOI: 10.1038/s41537-017-0036-2	npj Schizophrenia 3/1	2020-04-08
2017	I. M. J. Saris, M. Aghajani, S. J. A. van der Werff, N. J. A. van der Wee, B. W. J. H. Penninx Social functioning in patients with depressive and anxiety disorders published pages: 352-361, ISSN: 0001-690X, DOI: 10.1111/acps.12774	Acta Psychiatrica Scandinavica 136/4	2020-04-08
2017	Martien J. Kas, Brenda Penninx, Bernd Sommer, Alessandro Serretti, Celso Arango, Hugh Marston A quantitative approach to neuropsychiatry: The why and the how published pages: pending, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2017.12.008	Neuroscience & Biobehavioral Reviews 2017 Dec 12. pii: S0149-7634(17	2020-04-08

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