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NanoPD SIGNED

Single Molecule Nanoscale Sensors for Improved Therapies and Diagnostics

Total Cost €

EC-Contrib. €

Partnership

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NanoPD project word cloud

Explore the words cloud of the NanoPD project. It provides you a very rough idea of what is the project "NanoPD" about.

chemical limitation levels detecting accurate identification detection ensemble considering molecules quantification strategies removing discrimination markers nanoscale enormous averaging copy trace efficient sensitive mixtures amongst single samples clouding intend selective molecule compounded analyte stage unprocessed existed label events disease free pursued lacking smaller therapeutics context one near healthcare community clinical biosensing modification sensing heavily diagnostics

Project "NanoPD" data sheet

The following table provides information about the project.

Coordinator	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	1˙997˙680 €
EC max contribution	1˙997˙680 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-COG
Funding Scheme	ERC-COG
Starting year	2017
Duration (year-month-day)	from 2017-10-01 to 2022-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	1˙997˙680.00

Map

Project objective

One of the most significant challenges facing the healthcare community is the accurate and selective detection and quantification of trace levels of analyte. This can have enormous impact with numerous application, especially in the context of biosensing, where applications can range from early stage detection of disease to the identification of new markers amongst others. These challenges are compounded when the analysis of real samples or even complex mixtures are required. To address this need, single molecule or near single molecule methods are currently being heavily pursued which allows for the discrimination of events with low copy numbers by removing the “clouding” associated with ensemble averaging. Although strategies for detecting single molecules have existed for a number of years, efficient and cost-effective label-free methods without the need for chemical modification are lacking especially when considering smaller molecules directly in unprocessed clinical samples. As part of this proposal, I intend to address this limitation by developing new strategies in single molecule nanoscale sensing which will be both highly sensitive and selective for improved therapeutics and diagnostics applications.

Publications

List of publications.
year	authors and title	journal	last update
2019	Ye Ma, Debabrata Sikdar, Aleksandra Fedosyuk, Leonora Velleman, Daniel J. Klemme, Sang-Hyun Oh, Anthony R. J. Kucernak, Alexei A. Kornyshev, Joshua B. Edel Electrotunable Nanoplasmonics for Amplified Surface Enhanced Raman Spectroscopy published pages: , ISSN: 1936-0851, DOI: 10.1021/acsnano.9b05257	ACS Nano	2020-01-30
2019	Shenglin Cai, Jasmine Y. Y. Sze, Aleksandar P. Ivanov, Joshua B. Edel Small molecule electro-optical binding assay using nanopores published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09476-4	Nature Communications 10/1	2020-01-30
2019	Yanjun Zhang, Yasufumi Takahashi, Sung Pil Hong, Fengjie Liu, Joanna Bednarska, Philip S. Goff, Pavel Novak, Andrew Shevchuk, Sahana Gopal, Iros Barozzi, Luca Magnani, Hideki Sakai, Yoshimoto Suguru, Takuto Fujii, Alexander Erofeev, Peter Gorelkin, Alexander Majouga, Dominik J. Weiss, Christopher Edwards, Aleksandar P. Ivanov, David Klenerman, Elena V. Sviderskaya, Joshua B. Edel, Yuri Korchev High-resolution label-free 3D mapping of extracellular pH of single living cells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-13535-1	Nature Communications 10/1	2020-01-30
2019	MarkÃ©ta KubÃ¡nkovÃ¡, Xiaoyan Lin, Tim Albrecht, Joshua B. Edel, Marina K. Kuimova Rapid Fragmentation during Seeded Lysozyme Aggregation Revealed at the Single Molecule Level published pages: , ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b01221	Analytical Chemistry	2020-01-30
2019	Ye Ma, Debabrata Sikdar, Aleksandra Fedosyuk, Leonora Velleman, Minggang Zhao, Longhua Tang, Alexei A. Kornyshev, Joshua B. Edel Auxetic Thermoresponsive Nanoplasmonic Optical Switch published pages: 22754-22760, ISSN: 1944-8244, DOI: 10.1021/acsami.9b05530	ACS Applied Materials & Interfaces 11/25	2020-01-30
2017	L. Velleman, L. Scarabelli, D. Sikdar, A. A. Kornyshev, L. M. Liz-MarzÃ¡n, J. B. Edel Monitoring plasmon coupling and SERS enhancement through in situ nanoparticle spacing modulation published pages: 67-83, ISSN: 1359-6640, DOI: 10.1039/c7fd00162b	Faraday Discussions 205	2019-06-11
2017	Paolo Cadinu, Binoy Paulose Nadappuram, Dominic J. Lee, Jasmine Y. Y. Sze, Giulia Campolo, Yanjun Zhang, Andrew Shevchuk, Sylvain Ladame, Tim Albrecht, Yuri Korchev, Aleksandar P. Ivanov, Joshua B. Edel Single Molecule Trapping and Sensing Using Dual Nanopores Separated by a Zeptoliter Nanobridge published pages: 6376-6384, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.7b03196	Nano Letters 17/10	2019-06-11
2017	Jasmine Y. Y. Sze, Aleksandar P. Ivanov, Anthony E. G. Cass, Joshua B. Edel Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01584-3	Nature Communications 8/1	2019-06-11
2018	Liang Xue, Paolo Cadinu, Binoy Paulose Nadappuram, Minkyung Kang, Ye Ma, Yuri Korchev, Aleksandar P. Ivanov, Joshua B. Edel Gated Single-Molecule Transport in Double-Barreled Nanopores published pages: 38621-38629, ISSN: 1944-8244, DOI: 10.1021/acsami.8b13721	ACS Applied Materials & Interfaces 10/44	2019-06-11
2018	Hayley Weir, Joshua B. Edel, Alexei A. Kornyshev, Debabrata Sikdar Towards Electrotuneable Nanoplasmonic Fabryâ€“Perot Interferometer published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-19011-4	Scientific Reports 8/1	2019-06-11
2017	Avijit Barik, Yao Zhang, Roberto Grassi, Binoy Paulose Nadappuram, Joshua B. Edel, Tony Low, Steven J. Koester, Sang-Hyun Oh Graphene-edge dielectrophoretic tweezers for trapping of biomolecules published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01635-9	Nature Communications 8/1	2019-06-11
2018	Paolo Cadinu, Giulia Campolo, Sergii Pud, Wayne Yang, Joshua B. Edel, Cees Dekker, Aleksandar P. Ivanov Double Barrel Nanopores as a New Tool for Controlling Single-Molecule Transport published pages: 2738-2745, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b00860	Nano Letters 18/4	2019-06-11
2017	Ren Ren, Yanjun Zhang, Binoy Paulose Nadappuram, Bernice Akpinar, David Klenerman, Aleksandar P. Ivanov, Joshua B. Edel, Yuri Korchev Nanopore extended field-effect transistor for selective single-molecule biosensing published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-00549-w	Nature Communications 8/1	2019-06-11
2019	Binoy Paulose Nadappuram, Paolo Cadinu, Avijit Barik, Alexander J. Ainscough, Michael J. Devine, Minkyung Kang, Jorge Gonzalez-Garcia, Josef T. Kittler, Keith R. Willison, Ramon Vilar, Paolo Actis, Beata Wojciak-Stothard, Sang-Hyun Oh, Aleksandar P. Ivanov, Joshua B. Edel Nanoscale tweezers for single-cell biopsies published pages: 80-88, ISSN: 1748-3387, DOI: 10.1038/s41565-018-0315-8	Nature Nanotechnology 14/1	2019-06-11
2018	Ye Ma, Cristian Zagar, Daniel J. Klemme, Debabrata Sikdar, Leonora Velleman, Yunuen Montelongo, Sang-Hyun Oh, Anthony R. Kucernak, Joshua B. Edel, Alexei A. Kornyshev A Tunable Nanoplasmonic Mirror at an Electrochemical Interface published pages: 4604-4616, ISSN: 2330-4022, DOI: 10.1021/acsphotonics.8b01105	ACS Photonics 5/11	2019-06-11
2018	Dana Al Sulaiman, Paolo Cadinu, Aleksandar P. Ivanov, Joshua B. Edel, Sylvain Ladame Chemically Modified Hydrogel-Filled Nanopores: A Tunable Platform for Single-Molecule Sensing published pages: 6084-6093, ISSN: 1530-6984, DOI: 10.1021/acs.nanolett.8b03111	Nano Letters 18/9	2019-06-11
2018	Viktoria Rakers, Paolo Cadinu, Joshua B. Edel, Ramon Vilar Development of microfluidic platforms for the synthesis of metal complexes and evaluation of their DNA affinity using online FRET melting assays published pages: 3459-3469, ISSN: 2041-6520, DOI: 10.1039/c8sc00528a	Chemical Science 9/14	2019-06-11
2017	William J. Peveler, Sacha Noimark, Hassan Al-Azawi, Gi Byoung Hwang, Colin R. Crick, Elaine Allan, Joshua B. Edel, Aleksandar P. Ivanov, Alexander J. MacRobert, Ivan P. Parkin Covalently Attached Antimicrobial Surfaces Using BODIPY: Improving Efficiency and Effectiveness published pages: 98-104, ISSN: 1944-8244, DOI: 10.1021/acsami.7b13273	ACS Applied Materials & Interfaces 10/1	2019-06-11
2018	Aleksandar P. Ivanov, Joshua B. Edel Scissoring genes with light published pages: 800-801, ISSN: 1755-4330, DOI: 10.1038/s41557-018-0116-6	Nature Chemistry 10/8	2019-06-11
2017	Yunuen Montelongo, Debabrata Sikdar, Ye Ma, Alastair J. S. McIntosh, Leonora Velleman, AnthonyÂ R. Kucernak, Joshua B. Edel, Alexei A. Kornyshev Electrotunable nanoplasmonic liquid mirror published pages: 1127-1135, ISSN: 1476-1122, DOI: 10.1038/nmat4969	Nature Materials 16/11	2019-06-11

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