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FLEXOBONEGRAFT

FLEXOELECTRIC SCAFFOLDS FOR BONE TISSUE ENGINEERING

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

FLEXOBONEGRAFT project word cloud

Explore the words cloud of the FLEXOBONEGRAFT project. It provides you a very rough idea of what is the project "FLEXOBONEGRAFT" about.

transplant progress pcl polymers catalan 2020 polarize geometrical 3d amounts calculations light plga character economic effect economy attained scaffold engineering regeneration last manufactured gradient pore line stimulate gustau calls ago envisaged bone materials shape owing mechanical flexoelectricity socio osteoconductive inhomogeneous flourished view innovation whereby demographic flexoelectric synthetic plla dr dielectric transplanted scaffolds wt incorporate generate million refine burden decades exhibit biomimic few finite strain weeks geometries horizon discovery groundbreaking strategies ageing coupling gradients polarization careful osteogenic tissue porosity smart biology icn2 nanohydroxyapatite solid printing deformation

Project "FLEXOBONEGRAFT" data sheet

The following table provides information about the project.

Coordinator	FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA Organization address address: CAMPUS DE LA UAB EDIFICI Q ICN2 city: BELLATERRA (BARCELONA) postcode: 8193 website: www.icn.cat contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	https://icn2.cat/en/oxide-nanophysics-group
Total cost	158˙121 €
EC max contribution	158˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-09-15 to 2019-10-03

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA Organization address address: CAMPUS DE LA UAB EDIFICI Q ICN2 city: BELLATERRA (BARCELONA) postcode: 8193 website: www.icn.cat contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BELLATERRA (BARCELONA))	coordinator	158˙121.00

Map

Project objective

'Bone is the most transplanted tissue with 1.3 million procedures every year in Europe. With an increasing demographic ageing across Europe, bone transplant represents a significant socio-economic burden that necessitates new bone regeneration strategies in line with one of the Horizon 2020 priority: 'Smart Growth: knowledge and innovation based economy'. The field of bone tissue engineering has flourished over the last decades, owing to a solid knowledge on bone biology and increased progress on materials engineering. A few weeks ago, Dr Gustau Catalan at ICN2 brought to light the groundbreaking discovery that bone is flexoelectric. In order to biomimic the flexoelectric character of bone, we aim in this project to produce new synthetic bone scaffolds that exhibit flexoelectricity. Engineering scaffolds with a flexoelectric character calls for particular design requirements. Flexoelectricity is the coupling between strain gradients and polarization, whereby any dielectric can polarize in response to an inhomogeneous deformation. In order to generate the required strain gradients within the scaffold to produce a flexoelectric effect, scaffolds will be manufactured with controlled porosity gradients by 3D printing based approaches. Three polymers used in bone tissue engineering, namely PLLA, PLGA and PCL will be investigated to produce the flexoelectric scaffolds. It is envisaged that a flexoelectric-induced polarization can be attained in any of them. In view of improving the osteoconductive, osteogenic and mechanical properties of the flexoelectric scaffolds, they will further incorporate different amounts of nanohydroxyapatite (from 0 to 50 wt %). Finite element calculations will be used to refine porosity geometries (porosity gradient and pore shape). It is expected that through careful geometrical design of porosity, scaffolds could exhibit a bone-like flexoelectric effect that would not only support the bone tissue regeneration process but also stimulate it.'

Publications

List of publications.
year	authors and title	journal	last update
2020	Raquel NÃºÃ±ez-ToldrÃ , Fabian Vasquez-Sancho, Nathalie Barroca, Gustau Catalan Effect of fracture flexoelectricity on bone cells. published pages: , ISSN: 2045-2322, DOI:	Scientific Reports	2020-03-11

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