HybridMiX SIGNED
Genetic Mapping of Evolutionary Developmental Variation using Hybrid Mouse in vitro Crosses
Total Cost €
0EC-Contrib. €
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Project "HybridMiX" data sheet
The following table provides information about the project.
| Coordinator |
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Total cost | 1˙499˙923 € |
| EC max contribution | 1˙499˙923 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-08-01 to 2020-07-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV | DE (Munich) | coordinator | 1˙499˙923.00 |
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Project objective
Discovering the genetic changes underlying species differences is a central goal in evolutionary genetics. Most evolutionarily important traits affecting fitness are complex or quantitative traits, whose genetic bases are elusive. In mammals, dissecting the genetic basis of complex trait variation is particularly challenging, because efficient genetic mapping requires enormous pedigrees or specialized genetic panels that are typically beyond the resources of individual groups. Using a radically novel method to circumvent breeding limitations by “breeding” mice in vitro, I propose to dissect the genetic basis of evolutionary developmental variation. This ground-breaking approach will allow me to create large genetic mapping panels of potentially any size from mouse interspecific hybrids of increasing evolutionary divergence. In vitro crosses promise a breakthrough in evolutionary biology: by bypassing hybrid sterility and inviability, we will ask which genetic changes underlie species differences. The proposed experiments address how genetic changes accumulate during evolution of new species to shape gene regulatory networks and cause phenotypic changes at the gene expression, fitness and organismal level. This research has the potential to revolutionize genetic mapping. If realized, its impact on personalized medicine, agricultural science and evolutionary research cannot be understated.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Andreea Dréau, Vrinda Venu, Elena Avdievich, Ludmila Gaspar, Felicity C. Jones Genome-wide recombination map construction from single individuals using linked-read sequencing published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12210-9 |
Nature Communications 10/1 | 2020-04-03 |
| 2018 |
Stefano Lazzarano, Marek KuÄka, João P. L. Castro, Ronald Naumann, Paloma Medina, Michael N. C. Fletcher, Rebecka Wombacher, Joost Gribnau, Tino Hochepied, Marc Van Montagu, Claude Libert, Yingguang Frank Chan Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells published pages: 201717474, ISSN: 0027-8424, DOI: 10.1073/pnas.1717474115 |
Proceedings of the National Academy of Sciences | 2019-05-28 |
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