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CATCH-U-DNA SIGNED

Capturing non-Amplified Tumor Circulating DNA with Ultrasound Hydrodynamics

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

CATCH-U-DNA project word cloud

Explore the words cloud of the CATCH-U-DNA project. It provides you a very rough idea of what is the project "CATCH-U-DNA" about.

labor perceived nanoparticles enhanced probes enrichment shapes anticipate frequency mutations hydrodynamic lung made efficiency acoustic surface device grail prognosis dna colorectal kras intensive zm treatment ultra push employing pcr demonstrated technological scientific simpler occurring proof intend validate medium replacing detecting holy benefit patients limit polymerase quantification area tumor foundations molecules probe obviating sensitive serum sizes platform braf ghz markers fabricate shape genetic affordable mass diagnostic amplification suggested capturing costly ctdna countries microfluidics occasionally cancers waves goals diagnosis cancer detection biased beads catch magnetic egfr suggests circulating tailor bound

Project "CATCH-U-DNA" data sheet

The following table provides information about the project.

Coordinator	IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Project website	https://catch-u-dna.com
Total cost	3˙412˙478 €
EC max contribution	3˙411˙478 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-06-01 to 2020-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IDRYMA TECHNOLOGIAS KAI EREVNAS IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (IRAKLEIO)	coordinator	682˙500.00
2	BEN-GURION UNIVERSITY OF THE NEGEV BEN-GURION UNIVERSITY OF THE NEGEV Organization address address: . city: BEER SHEVA postcode: 84105 website: www.bgu.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (BEER SHEVA)	participant	575˙337.00
3	PANEPISTIMIO KRITIS PANEPISTIMIO KRITIS Organization address address: UNIVERSITY CAMPUS GALLOS city: RETHIMNO postcode: 74100 website: www.uoc.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (RETHIMNO)	participant	546˙000.00
4	ADVANCED WAVE SENSORS S.L. ADVANCED WAVE SENSORS S.L. Organization address address: C/ CISCAR 40-8 city: VALENCIA postcode: 46005 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (VALENCIA)	participant	524˙000.00
5	INSTITUT CURIE INSTITUT CURIE Organization address address: rue d'Ulm 26 city: PARIS postcode: 75231 website: www.curie.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	456˙891.00
6	JOBST TECHNOLOGIES GMBH JOBST TECHNOLOGIES GMBH Organization address address: ENGESSERSTRASSE 4 B city: FREIBURG postcode: 79108 website: www.jobst-technologies.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FREIBURG)	participant	319˙250.00
7	UNIVERSIDAD AUTONOMA DE MADRID UNIVERSIDAD AUTONOMA DE MADRID Organization address address: CALLE EINSTEIN 3 CIUDAD UNIV CANTOBLANCO RECTORADO city: MADRID postcode: 28049 website: http://www.uam.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	307˙500.00

Map

Project objective

The project suggests replacing the labor-intensive, occasionally biased and costly PCR method currently used for the detection of genetic markers with a simple, non-PCR based DNA quantification method. The suggested system will exploit the ability of acoustic waves to probe the hydrodynamic shape of surface-bound molecules, rather than mass. The scientific challenge to be addressed is to push the limit of detection to the zM range obviating the need to use a polymerase for DNA amplification. The technological challenge is to fabricate ultra sensitive acoustic devices and after capturing with high efficiency very low numbers of DNA present in a complex medium detecting them on the device surface. These ambitious goals will be achieved by developing novel probes and nanoparticles of tailor-made sizes and shapes for enhanced acoustic response; exploiting high frequency acoustic devices up to the GHz range; and, employing magnetic beads with microfluidics for specific target-capturing and enrichment. The proof-of-principle will be demonstrated during the detection of circulating-tumor DNA (ctDNA), currently an area perceived by cancer researchers as the “Holy Grail” of future cancer diagnosis, prognosis and treatment. We intend to validate our integrated acoustic platform towards the detection of common mutations occurring in colorectal and lung cancers, i.e., KRAS, EGFR and BRAF in serum. We anticipate that the “CATCH-U-DNA” concept will set the foundations for a simpler, more sensitive and affordable diagnostic method, from which patients in both the developed and developing countries will greatly benefit.

Deliverables

List of deliverables.
Targeted NGS analysis on the tissue samples of the 200 patients	Documents, reports	2020-03-24 09:14:05
Website construction	Websites, patent fillings, videos etc.	2020-03-24 09:14:05

Take a look to the deliverables list in detail: detailed list of CATCH-U-DNA deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Karla Perez-Toralla, Iago Pereiro, Sonia Garrigou, Fahima Di Federico, Charlotte Proudhon, FranÃ§ois-ClÃ©ment Bidard, Jean-Louis Viovy, ValÃ©rie Taly, StÃ©phanie Descroix Microfluidic extraction and digital quantification of circulating cell-free DNA from serum published pages: 533-539, ISSN: 0925-4005, DOI: 10.1016/j.snb.2019.01.159	Sensors and Actuators B: Chemical 286	2020-03-24
2019	George Papadakis, Alexandros K. Pantazis, Maria Ntogka, Konstantinos Parasyris, Gesthimani-Ioanna Theodosi, Georgia Kaprou, Electra Gizeli 3D-printed Point-of-Care Platform for Genetic Testing of Infectious Diseases Directly in Human Samples Using Acoustic Sensors and a Smartphone published pages: 1329-1336, ISSN: 2379-3694, DOI: 10.1021/acssensors.9b00264	ACS Sensors 4/5	2020-03-24

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The information about "CATCH-U-DNA" are provided by the European Opendata Portal: CORDIS opendata.