#	Pagina
attuale pagina	/open-h2020/projects/211213/index.html

Opendata, web and dolomites

IMGENE SIGNED

Improving Genome Editing Efficiency (IMGENE)

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

IMGENE project word cloud

Explore the words cloud of the IMGENE project. It provides you a very rough idea of what is the project "IMGENE" about.

manner genome molecular bioinformatics editing society solved industry multidisciplinary consisting reaction gene science chain protocols academia career therapy humans introducing unites greatest eager animals complementary viral benefit combining pharmaceutical protein leaders organization alliance health ago tackle genetic crispr skills scientifically companies milliporesigma mice life vectors transgenic biology concerted training 25 taconic invention gain chemistry innovative beneficiary full economically groups educate improvement biomedical esrs imgene network additional limiting academic precise basic technological ethical polymerase patient tools expert astrazeneca perspectives transferable acceptance excellent unleash industrial intersectorial cellular efficiency questions plants

Project "IMGENE" data sheet

The following table provides information about the project.

Coordinator	KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Denmark [DK]
Project website	https://imgene.ku.dk/
Total cost	2˙068˙409 €
EC max contribution	2˙068˙409 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2017
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2021-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	coordinator	580˙163.00
2	ASTRAZENECA AB ASTRAZENECA AB Organization address address: Vastra Maelarhamnen city: SODERTAELJE postcode: 151 85 website: www.astrazeneca.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SODERTAELJE)	participant	263˙659.00
3	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	255˙374.00
4	MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) Organization address address: ROBERT ROSSLE STRASSE 10 city: BERLIN postcode: 13125 website: www.mdc-berlin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	249˙216.00
5	UNIVERSITAETSKLINIKUM FREIBURG UNIVERSITAETSKLINIKUM FREIBURG Organization address address: HUGSTETTER STRASSE 49 city: FREIBURG postcode: 79106 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FREIBURG)	participant	249˙216.00
6	INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC Organization address address: RUA ALFREDO ALLEN 208 city: PORTO postcode: 4200 135 website: www.ibmc.up.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (PORTO)	participant	238˙356.00
7	USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE USTAV MOLEKULARNI GENETIKY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE Organization address address: VIDENSKA 1083 city: PRAHA 4 postcode: 142 20 website: www.img.cas.cz contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA 4)	participant	232˙422.00
8	Genetic Alliance Genetic Alliance Organization address address: UNIT 4D LEROY HOUSE , ESSEX ROAD 436 city: LONDON postcode: N1 3QP website: www.gig.org.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	partner	0.00
9	Millipore Sigma Millipore Sigma Organization address address: n.a. city: Massachusetts postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (Massachusetts)	partner	0.00
10	Taconic GmbH Taconic GmbH Organization address address: n.a. city: Cologne postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Cologne)	partner	0.00

Map

Project objective

CRISPR genome editing technology is considered to become the greatest technological improvement in biomedical research since the invention of the polymerase chain reaction 25 years ago and pharmaceutical companies as well as academic research are eager to apply it. However, the efficiency of introducing defined changes into the genome by CRISPR is still low, currently limiting its application in basic research, industry and gene therapy. IMGENE unites expert European research groups of academia and industry to address by innovative and complementary approaches the low efficiency of precise genome editing using CRISPR technology. To our best knowledge, IMGENE is the only concerted approach to tackle the important problem of low genome editing efficiency of CRISPR in a multidisciplinary, intersectorial manner. The IMGENE consortium consisting of 6 academic and 1 industrial beneficiary (AstraZeneca), 2 industrial partners (Taconic; MilliporeSigma), and the patient organization Genetic Alliance, aims to improve the genome editing efficiency of CRISPR by research training of 8 ESRs to unleash the full potential of this technology. Combining complementary knowledge on protein chemistry, molecular biology, cellular biology, viral vectors, transgenic mice, gene therapy, and bioinformatics present in the network, IMGENE will establish novel tools and protocols for improved CRISPR genome editing efficiency that will be of immediate benefit for health and life science research, the pharmaceutical industry, and the application of gene therapy. In addition, IMGENE addresses crucial ethical questions related to the application of genome editing technology in animals, plants, and humans, which have to be solved to gain acceptance by the society. By excellent research training of 8 ESRs on a scientifically and economically highly relevant topic and additional training in transferable skills, IMGENE will educate novel leaders with great career perspectives in industry and academia.

Publications

List of publications.
year	authors and title	journal	last update
2019	Xiaoyu Chen, Francesca Tasca, Qian Wang, Jin Liu, Josephine M Janssen, Marcella D Brescia, Milena Bellin, Karoly Szuhai, Josefin Kenrick, Richard L Frock, Manuel A F V GonÃ§alves Expanding the editable genome and CRISPRâ€“Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gkz1121	Nucleic Acids Research	2020-01-30

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "IMGENE" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "IMGENE" are provided by the European Opendata Portal: CORDIS opendata.