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NeuroQure SIGNED

Neuroprotective human antibodies to the flexible tail of the prion protein

Total Cost €

EC-Contrib. €

Partnership

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NeuroQure project word cloud

Explore the words cloud of the NeuroQure project. It provides you a very rough idea of what is the project "NeuroQure" about.

com diseases adriano cloning therapies cells heavy mabylon antiprion pathologies safety murine ind investigational therapeutics infectious protein fast fatal tail throughput light principal founded ft framework health yield superior completion human company express erc investigator memory individuals cellular candidates profiles invariably persons screening chains track autoimmunity humans team paired neuroprotective immunoreactive clone devoid disease clinical discovered untreatable causes anti humanized rare aguzzi antibodies flexible prpc prion neurodegenerative drug misfolding populations

Project "NeuroQure" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: Zürich postcode: 8006 website: http://www.unizh.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-PoC
Funding Scheme	ERC-POC
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2019-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAT ZURICH UNIVERSITAT ZURICH Organization address address: RAMISTRASSE 71 city: Zürich postcode: 8006 website: http://www.unizh.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (Zürich)	coordinator	150˙000.00

Map

Project objective

The misfolding of the cellular prion protein (PrPC) causes infectious neurodegenerative conditions called prion diseases. In the framework of the ERC-funded study “The Prion Protein in Health and Disease” the team of Adriano Aguzzi has discovered that antibodies against the flexible tail (FT) of PrPC are neuroprotective against prion pathologies. Here we propose to clone and express such antibodies from humans and to develop them as antiprion therapeutics. The principal investigator has founded a company (www.mabylon.com) which has established a high-yield method for cloning paired heavy and light chains from human memory B cells. The proposed research program will identify rare anti-FT immunoreactive individuals among large populations by high-throughput screening. The clinical information of the selected individuals will help to identify antibodies from persons devoid of pathologies that may be related to anti-PrPC autoimmunity. Therefore, the human antibodies generated within this program will represent fast-track investigational new drug (IND) candidates with safety profiles superior to those of murine or humanized antibodies. Completion of the proposed activities will lead to the development of therapies against prion diseases, which are currently considered untreatable and invariably fatal.

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The information about "NEUROQURE" are provided by the European Opendata Portal: CORDIS opendata.