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MALEPREG SIGNED

Male pregnancy – Unravelling the coevolution of parental investment and immune defence

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EC-Contrib. €

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Partnership

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 Outcomes and results

 MALEPREG project word cloud

Explore the words cloud of the MALEPREG project. It provides you a very rough idea of what is the project "MALEPREG" about.

immunological    reversed    tolerance    pave    functions    full    functionalization    genomic    co    engineering    investment    de    composition    mammalian    parental    fertilisation    female    textbook    controversial    cas9    immune    unresolved    genomics    adaptive    gradient    question    genus    emergence    sex    fresh    costliest    trait    model    egg    convergent    microbiota    fundamentally    groups    mammals    heavily    young    severely    independent    understudied    belongs    disentangled    mating    plan    accompanied    transcriptomics    reproduction    vertebrates    novo    biased    utilizing    placentation    fitness    male    ideal    viviparity    syngnathids    microbial    basis    seahorses    regarding    analysing    gain    gene    bearing    traits    reorganisations    crispr    genetic    evolution    duplication    roles    elucidate    arose    biology    morphological    pregnancy    neo    benefits    option    caused    coevolved    species    drastic    vertebrate    pipefishes    form    external    look    broodpouch    rearrangements    evolutionary   

Project "MALEPREG" data sheet

The following table provides information about the project.

Coordinator		 HELMHOLTZ ZENTRUM FUR OZEANFORSCHUNG KIEL 

Organization address
address: WISCHHOFSTRASSE 1-3
city: KIEL
postcode: 24148
website: www.geomar.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Germany [DE]
 Project website https://www.geomar.de/en/staff/fb3/ev/oroth/
 Total cost 1˙499˙989 €
 EC max contribution 1˙499˙989 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELMHOLTZ ZENTRUM FUR OZEANFORSCHUNG KIEL DE (KIEL) coordinator 1˙499˙989.00

Map

 Project objective

The question of how sex roles and parental investment have evolved belongs to the most controversial unresolved issues in evolutionary biology. The costliest form of reproduction regarding parental investment is viviparity. Its independent evolution in most vertebrate groups has required drastic morphological and genomic reorganisations in the sex bearing the young. Yet our knowledge is heavily biased towards mammals, where changes in the immune system and microbial composition are associated with pregnancy and placentation. Which factors have caused the selection and accompanied evolution of viviparity in other vertebrates remains severely understudied. As the evolution of viviparity is a textbook model of convergent evolution, I plan on using a comparative approach to identify selection and fitness benefits leading to the evolution of viviparity. I propose analysing mating system evolution, focusing on the unique evolution of male pregnancy in sex-role reversed syngnathids (pipefishes and seahorses) that show a gradient from external fertilisation to full viviparity and are, thus, ideal to study the evolution of viviparity. Only this genus allows the role of egg production and viviparity to be disentangled, as both traits co-occur in the female in most other species. As immunological tolerance is fundamentally associated with the evolution of pregnancy, I will investigate how male pregnancy has coevolved with adaptive immune system rearrangements and the broodpouch specific microbiota. Comparative genomics, transcriptomics and genetic engineering utilizing CRISPR/Cas9 will elucidate the genetic basis of trait loss and gain required for male pregnancy. In particular, I will assess whether new functions arose via gene duplication and neo-functionalization, via gene co-option or via de novo gene emergence. This proposal will pave the way for studying viviparity evolution beyond the mammalian model and will provide a fresh look at sex roles and parental investment.

 Publications

year authors and title journal last update
List of publications.
2019 Anne Beemelmanns, Maude Poirier, Till Bayer, Sven Kuenzel, Olivia Roth
Microbial embryonal colonization during pipefish male pregnancy
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37026-3 		Scientific Reports 9/1 2019-11-07
2019 Charlotte Jessica E. Metcalf, Olivia Roth, Andrea L. Graham
Why leveraging sex differences in immune trade‐offs may illuminate the evolution of senescence
published pages: , ISSN: 0269-8463, DOI: 10.1111/1365-2435.13458 		Functional Ecology 2019-11-07

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