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GLIOTRAIN SIGNED

Exploiting GLIOblastoma intractability to address European research TRAINing needs in translational brain tumour research, cancer systems medicine and integrative multi-omics

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

GLIOTRAIN project word cloud

Explore the words cloud of the GLIOTRAIN project. It provides you a very rough idea of what is the project "GLIOTRAIN" about.

gliotrain lethal brain tumour fatal trained frequent collaborations options intractability training treatment sequencing generation unravel disciplines confidently outcomes academic countries brings profit precision 14 integrative clinical 15 aggressive omics environments interrogating cancer academia clinically medicine disease models beneficiaries entrepreneurial bioinformatics therapies sectoral leveraging gbm unmet private drug biomedical strategies progress esrs patient creative clinicians technologies international latest industry biology etn urgently therapeutic patients universally glioblastoma computational mechanistic 85 tumours spans resistance train innovative dying translational environment newly incorporate navigate implementing platform academics mechanisms prognosis

Project "GLIOTRAIN" data sheet

The following table provides information about the project.

Coordinator	ROYAL COLLEGE OF SURGEONS IN IRELAND Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ireland [IE]
Project website	https://www.gliotrain.eu/
Total cost	3˙836˙772 €
EC max contribution	3˙836˙772 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2017
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2021-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ROYAL COLLEGE OF SURGEONS IN IRELAND ROYAL COLLEGE OF SURGEONS IN IRELAND Organization address address: Saint Stephen's Green 123 city: DUBLIN postcode: 2 website: www.rcsi.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN)	coordinator	1˙062˙698.00
2	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	510˙748.00
3	VIB VZW VIB VZW Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE - GENT)	participant	501˙120.00
4	UNIVERSITAET STUTTGART UNIVERSITAET STUTTGART Organization address address: KEPLERSTRASSE 7 city: STUTTGART postcode: 70174 website: www.uni-stuttgart.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (STUTTGART)	participant	498˙432.00
5	INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE Organization address address: BOULEVARD DE L'HOPITAL 47 city: PARIS postcode: 75013 website: http://icm-institute.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	262˙875.00
6	AGILENT TECHNOLOGIES BELGIUM NV AGILENT TECHNOLOGIES BELGIUM NV Organization address address: DE KLEETLAAN 5 city: DIEGEM postcode: 1831 website: http://www.ict-samurai.eu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (DIEGEM)	participant	250˙560.00
7	INFORMATION TECHNOLOGY FOR TRANSLATIONAL MEDICINE (ITTM) SA INFORMATION TECHNOLOGY FOR TRANSLATIONAL MEDICINE (ITTM) SA Organization address address: 9 AVENUE DES HAUTS-FORNEAUX city: Esch-sur-Alzette postcode: 4362 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LU (Esch-sur-Alzette)	participant	250˙560.00
8	LUXEMBOURG INSTITUTE OF HEALTH LUXEMBOURG INSTITUTE OF HEALTH Organization address address: VAL FLEURI 84 city: LUXEMBOURG postcode: 1526 website: https://www.lih.lu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LU (LUXEMBOURG)	participant	250˙560.00
9	GENEXPLAIN GMBH GENEXPLAIN GMBH Organization address address: AM EXER 19 B city: WOLFENBUTTEL postcode: 38302 website: www.genexplain.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (WOLFENBUTTEL)	participant	249˙216.00
10	BMS France BMS France Organization address address: n.a. city: Argonay postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Argonay)	partner	0.00
11	CarThera CarThera Organization address address: ICM - Hopital Pitie Salpetriere - 47, bd de l’Hopital city: Paris postcode: 75013 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Paris)	partner	0.00
12	Champions Oncology, Inc. Champions Oncology, Inc. Organization address address: One University Plaza city: Hackensack, NJ postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (Hackensack, NJ)	partner	0.00
13	INSILICO BIOTECHNOLOGY AG INSILICO BIOTECHNOLOGY AG Organization address address: MEITNERSTRASSE 9 city: STUTTGART postcode: 70563 website: www.insilico-biotechnology.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (STUTTGART)	partner	0.00
14	International Brain Tumour Alliance International Brain Tumour Alliance Organization address address: C/O Hamlins LLP, Roxburghe House, Regent Street 273 - 287 city: London postcode: W1B 2AD website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (London)	partner	0.00
15	IRISH CLINICAL ONCOLOGY RESEARCH GROUP LIMITED LBG IRISH CLINICAL ONCOLOGY RESEARCH GROUP LIMITED LBG Organization address address: INNOVATION HOUSE DCU ALPHA FINGLAS ROAD OLD city: DUBLIN 11 postcode: D11 KXN4 website: www.icorg.ie contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IE (DUBLIN 11)	partner	0.00
16	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	partner	0.00
17	MEDIZINISCHE HOCHSCHULE HANNOVER MEDIZINISCHE HOCHSCHULE HANNOVER Organization address address: Carl-Neuberg-Strasse 1 city: HANNOVER postcode: 30625 website: www.mh-hannover.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HANNOVER)	partner	0.00
18	MIMETAS BV MIMETAS BV Organization address address: JH Oortweg 19 city: Leiden postcode: 2333CH website: www.mimetas.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Leiden)	partner	0.00
19	Oncurious NV Oncurious NV Organization address address: Gaston Geenslaan 1 city: Leuven postcode: 3001 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (Leuven)	partner	0.00
20	Pepscope BV Pepscope BV Organization address address: Dantelaan 83 city: Utrecht postcode: 3533 VB website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (Utrecht)	partner	0.00
21	TEVA PHARMACEUTICALS EUROPE B.V. TEVA PHARMACEUTICALS EUROPE B.V. Organization address address: PIET HEINKADE 107 city: AMSTERDAM postcode: 1019 GM website: www.tevapharm.com/Europe contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	partner	0.00
22	UNIVERSITE DU LUXEMBOURG UNIVERSITE DU LUXEMBOURG Organization address address: 2 AVENUE DE L'UNIVERSITE city: ESCH-SUR-ALZETTE postcode: 4365 website: http://wwwen.uni.lu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LU (ESCH-SUR-ALZETTE)	partner	0.00
23	YUMAB GmbH YUMAB GmbH Organization address address: Rebenring 33 city: Braunschweig postcode: 38106 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Braunschweig)	partner	0.00

Map

Project objective

Glioblastoma (GBM) is the most frequent, aggressive and lethal of all brain tumours. It has a universally fatal prognosis with 85% of patients dying within two years. New treatment options and effective precision medicine therapies are urgently required. This can only be achieved by focused multi-sectoral industry-academia collaborations in newly emerging, innovative research disciplines. GLIOTRAIN will exploit the intractability of GBM to address European applied biomedical research training needs. The ETN, which comprises 9 beneficiaries and 14 partner organisations from 8 countries, will train 15 innovative, creative and entrepreneurial ESRs. The research objective of GLIOTRAIN is to identify novel therapeutic strategies for application in GBM, while implementing state of the art next generation sequencing, systems medicine and integrative multi-omics to unravel disease resistance mechanisms. Research activities incorporate applied systems medicine, integrative multi-omics leveraging state of the art platform technologies, and translational cancer biology implementing the latest clinically relevant models. The consortium brings together leading European and international academics, clinicians, private sector and not-for-profit partners across GBM fields of tumour biology, multi-omics, drug development, clinical research, bioinformatics, computational modelling and systems biology. Thus, GLIOTRAIN will address currently unmet translational research and clinical needs in the GBM field by interrogating innovative therapeutic strategies and improving the mechanistic understanding of disease resistance. The GLIOTRAIN ETN addresses current needs in academia and the private sector for researchers that have been trained in an environment that spans translational research, medicine and computational biology, and that can navigate confidently between clinical, academic and private sector environments to progress applied research findings towards improved patient outcomes.

Deliverables

List of deliverables.
Dissemination and public engagement Report 1	Documents, reports	2020-01-14 15:07:41
GLIOTRAIN Web presence	Websites, patent fillings, videos etc.	2020-01-14 15:09:36
Dissemination and public engagement Report 2	Documents, reports	2020-01-14 15:06:43

Take a look to the deliverables list in detail: detailed list of GLIOTRAIN deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Annika Hantusch; Kushal K. Das; Ana J. GarcÃa-SÃ¡ez; Thomas Brunner; Markus Rehm Bax retrotranslocation potentiates Bcl-xLâ€™s antiapoptotic activity and is essential for switch-like transitions between MOMP competency and resistance published pages: 430, ISSN: 2041-4889, DOI: 10.1038/s41419-018-0464-6	Cell Death & Disease 9 (4)	2019-10-15
2019	Ian S. Miller, Liam P. Shiels, Emer Conroy, Kate Connor, Patrick Dicker, William M. Gallagher, Norma Oâ€™ Donovan, Robert S. Kerbel, John Crown, Annette T. Byrne Durability of cell line xenograft resection models to interrogate tumor micro-environment targeting agents published pages: 9204, ISSN: 2045-2322, DOI: 10.1038/s41598-019-45444-0	Scientific Reports 9/1	2019-10-15
2018	Frank A. Lincoln, Dirke Imig, Chiara Boccellato, Viktorija Juric, Janis Noonan, Roland E. Kontermann, Frank AllgÃ¶wer, Brona M. Murphy, Markus Rehm Sensitization of glioblastoma cells to TRAIL-induced apoptosis by IAP- and Bcl-2 antagonism published pages: 1112, ISSN: 2041-4889, DOI: 10.1038/s41419-018-1160-2	Cell Death & Disease 9/11	2019-10-15
2019	Bo Lou, Kate Connor, Kieron Sweeney, Ian S. Miller, Alice Oâ€™Farrell, Eduardo Ruiz-Hernandez, David M. Murray, Garry P. Duffy, Alan Wolfe, Enrico Mastrobattista, Annette T. Byrne, Wim E. Hennink RGD-decorated cholesterol stabilized polyplexes for targeted siRNA delivery to glioblastoma cells published pages: 679-693, ISSN: 2190-393X, DOI: 10.1007/s13346-019-00637-y	Drug Delivery and Translational Research 9/3	2019-10-15

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The information about "GLIOTRAIN" are provided by the European Opendata Portal: CORDIS opendata.