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COSY-BIO SIGNED

Control Engineering of Biological Systems for Reliable Synthetic Biology Applications

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

COSY-BIO project word cloud

Explore the words cloud of the COSY-BIO project. It provides you a very rough idea of what is the project "COSY-BIO" about.

relevance discipline paradigm prototyping feedback computer building small acting sustainability automatic controller living biotechnology biological cycles components controllers rational speed bio organisms human despite physical innovative complexity usefulness demonstrations full generally cell biology platform desired applicable technological noisy cells prove engineer translating proof shift closed rapid tackled synthetic overarching cellular envisage cosy yeast revolutionary strategies basic handle optimal steer populations difficulty dynamic individual modular engineering made experimental molecules loop fashion molecular multicellular tools microfluidics framework bacteria environmental explore free intrinsically external parts principles theoretical population

Project "COSY-BIO" data sheet

The following table provides information about the project.

Coordinator	FONDAZIONE TELETHON Organization address address: VIA VARESE 16/B city: ROMA postcode: 185 website: www.telethon.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	http://www.cosy-bio.eu
Total cost	2˙996˙856 €
EC max contribution	2˙975˙345 € (99%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2017
Duration (year-month-day)	from 2017-10-01 to 2020-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FONDAZIONE TELETHON FONDAZIONE TELETHON Organization address address: VIA VARESE 16/B city: ROMA postcode: 185 website: www.telethon.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	coordinator	555˙875.00
2	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	568˙347.00
3	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	participant	400˙000.00
4	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	398˙526.00
5	UNIVERSITY OF BRISTOL UNIVERSITY OF BRISTOL Organization address address: BEACON HOUSE QUEENS ROAD city: BRISTOL postcode: BS8 1QU website: www.bristol.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRISTOL)	participant	298˙196.00
6	UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Organization address address: CORSO UMBERTO I, 40 city: NAPOLI postcode: 80138 website: www.unina.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (NAPOLI)	participant	255˙500.00
7	INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE Organization address address: DOMAINE DE VOLUCEAU ROCQUENCOURT city: LE CHESNAY CEDEX postcode: 78153 website: www.inria.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (LE CHESNAY CEDEX)	participant	250˙000.00
8	UNIVERSITE DE PARIS UNIVERSITE DE PARIS Organization address address: 85 BD SAINT GERMAIN city: PARIS postcode: 75006 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	248˙900.00
9	UNIVERSITE PARIS DIDEROT - PARIS 7 UNIVERSITE PARIS DIDEROT - PARIS 7 Organization address address: RUE THOMAS MANN 5 city: PARIS postcode: 75205 website: www.univ-paris-diderot.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	0.00

Map

Project objective

Synthetic Biology aims at rational engineering of living organisms to improve human well-being and environmental sustainability, thus promising a paradigm shift in human technology. Its full potential has not been achieved yet because of the complexity of engineering biological systems where basic biological parts are intrinsically noisy and not modular. The overarching goal of COSY-BIO is to develop a theoretical framework and innovative technological tools to engineer reliable biological systems that are robust despite their individual components being not by translating principles of control engineering to molecular and cell biology. Automatic control is a well-established engineering discipline to build “controllers” to steer the dynamic behaviour of a physical system in a desired fashion. By building upon control engineering for physical systems and by exploiting the unique features of living organisms, this project will identify generally applicable approaches to design closed-loop feedback controllers for biological systems. To handle biological complexity, the project will explore three strategies of increasing difficulty “external” controllers, “embedded” controllers and “multi-cellular” controllers. External controllers will be implemented in a computer acting on cells using small molecules via microfluidics devices. Embedded controllers will be made from biological parts and integrated within individual cells to steer their behaviour. Multicellular controllers envisage two cell populations, one made up of cells with embedded controllers (controller cells) and the other will be the controlled population (target cells). In addition, a rapid prototyping platform will enable to speed up the design-build-test cycles by means of optimal experimental design, microfluidics and cell-free systems. Proof-of-principles demonstrations in bacteria and yeast with relevance to biotechnology will be tackled to prove the usefulness of this revolutionary technology.

Deliverables

List of deliverables.
Detailed Dissemination and Exploitation plan	Open Research Data Pilot	2020-02-19 08:19:36
Comparison of model identification strategies	Documents, reports	2020-02-19 08:19:36
Constructing and testing of reporters of the cell cycle	Demonstrators, pilots, prototypes	2020-02-19 08:19:36
Official Logo of COSY-BIO	Other	2020-02-19 08:19:36
Data Management plan	Open Research Data Pilot	2020-02-19 08:19:36
Website and intranet portal	Other	2020-02-19 08:19:36

Take a look to the deliverables list in detail: detailed list of COSY-BIO deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Gabriele Lillacci, Yaakov Benenson, Mustafa Khammash Synthetic control systems for high performance gene expression in mammalian cells published pages: 9855-9863, ISSN: 0305-1048, DOI: 10.1093/nar/gky795	Nucleic Acids Research 46/18	2020-02-19
2018	Lucia Bandiera, Zhaozheng Hou, Varun Kothamachu, Eva Balsa-Canto, Peter Swain, Filippo Menolascina On-Line Optimal Input Design Increases the Efficiency and Accuracy of the Modelling of an Inducible Synthetic Promoter published pages: 148, ISSN: 2227-9717, DOI: 10.3390/pr6090148	Processes 6/9	2020-02-19
2018	Nicolas Kylilis, Zoltan A. Tuza, Guy-Bart Stan, Karen M. Polizzi Tools for engineering coordinated system behaviour in synthetic microbial consortia published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05046-2	Nature Communications 9/1	2020-02-19
2018	Marc Rullan, Dirk Benzinger, Gregor W. Schmidt, Andreas Milias-Argeitis, Mustafa Khammash An Optogenetic Platform for Real-Time, Single-Cell Interrogation of Stochastic Transcriptional Regulation published pages: 745-756.e6, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.04.012	Molecular Cell 70/4	2020-02-19

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The information about "COSY-BIO" are provided by the European Opendata Portal: CORDIS opendata.