Explore the words cloud of the RTCure project. It provides you a very rough idea of what is the project "RTCure" about.
The following table provides information about the project.
Coordinator |
KAROLINSKA INSTITUTET
Organization address contact info |
Coordinator Country | Sweden [SE] |
Project website | http://www.rtcure.com |
Total cost | 13˙846˙865 € |
EC max contribution | 6˙000˙000 € (43%) |
Programme |
1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2)) |
Code Call | H2020-JTI-IMI2-2016-09-two-stage |
Funding Scheme | IMI2-RIA |
Starting year | 2017 |
Duration (year-month-day) | from 2017-09-01 to 2022-08-31 |
Take a look of project's partnership.
In line with IMI2 goals for improved therapies and precision medicine, the aim of this proposal is to prevent and treat RA or its progression by inhibiting maturation/expansion of pathogenic autoimmune responses through immune tolerising treatments of subjects not only in early stages of joint inflammation (undifferentiated arthritis and early RA) but also in even earlier defined stages i.e. before onset of joint inflammation, when patients have arthralgia and/or bone loss, or sub-clinical stages of joint inflammation.
Today, no drugs are approved for these early phases of RA development, where symptoms such as pain and fatigue cause major loss of life quality and where successful interference would prevent onset of disease. Thus, an important part of our work will be to achieve a better understanding of this as yet unexplored phase of disease. In the proposed project we will develop and validate new methods to identify individuals at high risk for RA, tools to monitor disease progress and expand and further develop cohorts suitable for these purposes. Furthermore we will validate and standardise methods to monitor immune tolerance to be used in clinical trials for tolerising therapies for RA. The aim is thus to interfere with the specific immune reactions that contribute to RA symptoms in such a way that a specific and long-lasting therapeutic effect (ultimately a cure) is accomplished for a major proportion of RA patients and prevention of diseases is accomplished in individuals at high risk for RA.
Investigator-initiated as well as company-sponsored clinical trials in well stratified patient groups will be performed in collaboration with SMEs and/or contributing pharma companies and their immune effects studied using the same panel of biomarkers allowing for standardisation across protocols. Our ambition is also to disseminate our experiences from RA to other rheumatic and other immune-mediated diseases.
Comparison of serologic features of at-risk individuals and recent onset arthritis patients | Documents, reports | 2020-04-14 16:13:06 |
Optimal participant population(s) for clinical studies of tolerogenic interventions | Documents, reports | 2020-04-14 16:13:06 |
Algorithm for predicting the development of arthritis | Documents, reports | 2020-04-14 16:13:06 |
Key risk predictors for the transition from the at-risk status to clinical arthritis | Documents, reports | 2020-04-14 16:13:06 |
ARIAA Midterm recruitment report | Documents, reports | 2020-04-14 16:13:06 |
Status on ongoing clinical trials in RTCure | Documents, reports | 2020-04-14 16:13:05 |
Arrange thematic workshops in collaboration with the other WPs | Other | 2020-04-14 16:13:05 |
Report on the core data set for characterisation of individuals at-risk for developing RA | Documents, reports | 2020-04-14 16:13:05 |
Build a multidisciplinary task force | Websites, patent fillings, videos etc. | 2020-04-14 16:13:05 |
Set up internal and external website with a RTCure logo | Websites, patent fillings, videos etc. | 2020-04-14 16:13:05 |
Screening and analysis of biological and clinical datasets | Documents, reports | 2020-04-14 16:13:05 |
Take a look to the deliverables list in detail: detailed list of RTCure deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Rachel Spiering, Manon A. A. Jansen, Matthew J. Wood, Anshorulloh A. Fath, Oliver Eltherington, Amy E. Anderson, Arthur G. Pratt, Willem van Eden, John D. Isaacs, Femke Broere, Catharien M. U. Hilkens Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis published pages: , ISSN: 1479-5876, DOI: 10.1186/s12967-019-2128-4 |
Journal of Translational Medicine 17/1 | 2020-04-14 |
2019 |
Eliana Goncalves-Alves, Victoria Saferding, Christopher Schliehe, Robert Benson, Mariola Kurowska-Stolarska, Julia Stefanie Brunner, Antonia Puchner, Bruno K. Podesser, Josef S. Smolen, Kurt Redlich, Michael Bonelli, James Brewer, Andreas Bergthaler, Günter Steiner, Stephan Blüml MicroRNA-155 Controls T Helper Cell Activation During Viral Infection published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01367 |
Frontiers in Immunology 10 | 2020-04-14 |
2019 |
Theresa Kissel, Karin Anna van Schie, Lise Hafkenscheid, Anders Lundquist, Heidi Kokkonen, Manfred Wuhrer, Tom WJ Huizinga, Hans Ulrich Scherer, René Toes, Solbritt Rantapää-Dahlqvist On the presence of HLA-SE alleles and ACPA-IgG variable domain glycosylation in the phase preceding the development of rheumatoid arthritis published pages: annrheumdis-2019, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2019-215698 |
Annals of the Rheumatic Diseases | 2020-04-14 |
2019 |
Lise Hafkenscheid, Emma Moel, Irene Smolik, Stacey Tanner, Xiaobo Meng, Bas C. Jansen, Albert Bondt, Manfred Wuhrer, Tom W. J. Huizinga, Rene E. M. Toes, Hani Elâ€Gabalawy, Hans U. Scherer N â€Linked Glycans in the Variable Domain of IgG Anti–Citrullinated Protein Antibodies Predict the Development of Rheumatoid Arthritis published pages: 1626-1633, ISSN: 2326-5191, DOI: 10.1002/art.40920 |
Arthritis & Rheumatology 71/10 | 2020-04-14 |
2019 |
David Simon, Arnd Kleyer, Sara Bayat, Koray Tascilar, Eleni Kampylafka, Timo Meinderink, Louis Schuster, Ramona Petrov, Anna-Maria Liphardt, Juergen Rech, Georg Schett, Axel J. Hueber Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-019-1938-3 |
Arthritis Research & Therapy 21/1 | 2020-04-14 |
2019 |
Tamás Németh, Krisztina Futosi, Marcell Szabó, Petra Aradi, Takashi Saito, Attila Mócsai, Zoltán Jakus Importance of Fc Receptor γ-Chain ITAM Tyrosines in Neutrophil Activation and in vivo Autoimmune Arthritis published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00252 |
Frontiers in Immunology 10 | 2020-04-14 |
2019 |
Karin Roos Ljungberg, Vijay Joshua, Thomas Skogh, Anders Eklund, C Magnus Sköld, Reza Karimi, Sven Nyrén, Anna Svärd, Anca I Catrina, Alf Kastbom Secretory anti-citrullinated protein antibodies in serum associate with lung involvement in early rheumatoid arthritis published pages: , ISSN: 1462-0324, DOI: 10.1093/rheumatology/kez377 |
Rheumatology | 2020-04-14 |
2019 |
Rochelle D. Vergroesen, Linda M. Slot, Barbera D. C. van Schaik, Marvyn T. Koning, Theo Rispens, Antoine H. C. van Kampen, René E. M. Toes, Hans U. Scherer N-Glycosylation Site Analysis of Citrullinated Antigen-Specific B-Cell Receptors Indicates Alternative Selection Pathways During Autoreactive B-Cell Development published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.02092 |
Frontiers in Immunology 10 | 2020-04-14 |
2018 |
Anna Neumann, Judith Haschka, Arnd Kleyer, Louis Schuster, Matthias Englbrecht, Andreas Berlin, Camille P. Figueiredo, David Simon, Christian Muschitz, Roland Kocijan, Heinrich Resch, Jürgen Rech, Georg Schett Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-018-1620-1 |
Arthritis Research & Therapy 20/1 | 2020-04-14 |
2019 |
Kaja Eriksson, Guozhong Fei, Anna Lundmark, Daniel Benchimol, Linkiat Lee, Yue O. O. Hu, Anna Kats, Saedis Saevarsdottir, Anca Irinel Catrina, Björn Klinge, Anders F. Andersson, Lars Klareskog, Karin Lundberg, Leif Jansson, Tülay Yucel-Lindberg Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis published pages: 630, ISSN: 2077-0383, DOI: 10.3390/jcm8050630 |
Journal of Clinical Medicine 8/5 | 2020-04-14 |
2019 |
Esperanza Perucha, Rossella Melchiotti, Jack A Bibby, Wing Wu, Klaus Stensgaard Frederiksen, Ceri A. Roberts, Zoe Hall, Gaelle LeFriec, Kevin A. Robertson, Paul Lavender, Jens Gammeltoft Gerwien, Leonie S. Taams, Julian L. Griffin, Emanuele de Rinaldis, Lisa G. M. van Baarsen, Claudia Kemper, Peter Ghazal, Andrew P. Cope The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-08332-9 |
Nature Communications 10/1 | 2020-04-14 |
2019 |
Meng Sun, Bence Rethi, Akilan Krishnamurthy, Vijay Joshua, Alexandra Circiumaru, Aase Haj Hensvold, Elena Ossipova, Caroline Grönwall, Yanying Liu, Marianne Engstrom, Sergiu Bogdan Catrina, Johanna Steen, Vivianne Malmstrom, Lars Klareskog, Camilla Svensson, Caroline Ospelt, Heidi Wähämaa, Anca Irinel Catrina Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts published pages: annrheumdis-2018, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2018-214967 |
Annals of the Rheumatic Diseases | 2020-04-14 |
2018 |
Lianne P. W. M. Lelieveldt, Hendy Kristyanto, Ger J. M. Pruijn, Hans Ulrich Scherer, René E. M. Toes, Kimberly M. Bonger Sequential Prodrug Strategy To Target and Eliminate ACPA-Selective Autoreactive B Cells published pages: 5565-5573, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.8b00741 |
Molecular Pharmaceutics 15/12 | 2020-04-14 |
2018 |
David Simon, Arnd Kleyer, Francesca Faustini, Matthias Englbrecht, Judith Haschka, Andreas Berlin, Sebastian Kraus, Axel J. Hueber, Roland Kocijan, Michael Sticherling, Juergen Rech, Georg Schett Simultaneous quantification of bone erosions and enthesiophytes in the joints of patients with psoriasis or psoriatic arthritis - effects of age and disease duration published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-018-1691-z |
Arthritis Research & Therapy 20/1 | 2020-04-14 |
2019 |
P. Wehr, H. Purvis, S.â€C. Law, R. Thomas Dendritic cells, T cells and their interaction in rheumatoid arthritis published pages: 12-27, ISSN: 0009-9104, DOI: 10.1111/cei.13256 |
Clinical & Experimental Immunology 196/1 | 2020-04-14 |
2019 |
Andrew P. Cope Considerations for Optimal Trial Design for Rheumatoid Arthritis Prevention Studies published pages: 1299-1311, ISSN: 0149-2918, DOI: 10.1016/j.clinthera.2019.04.014 |
Clinical Therapeutics 41/7 | 2020-04-14 |
2019 |
Eleni Kampylafka, David Simon, Isabelle d’Oliveira, Christina Linz, Veronika Lerchen, Matthias Englbrecht, Juergen Rech, Arnd Kleyer, Michael Sticherling, Georg Schett, Axel J. Hueber Disease interception with interleukin-17 inhibition in high-risk psoriasis patients with subclinical joint inflammation—data from the prospective IVEPSA study published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-019-1957-0 |
Arthritis Research & Therapy 21/1 | 2020-04-14 |
2018 |
Janka Zsófia Csepregi, Anita Orosz, Erik Zajta, Orsolya Kása, Tamás Németh, Edina Simon, Szabina Fodor, Katalin Csonka, Balázs L. Barátki, Dorottya Kövesdi, You-Wen He, Attila Gácser, Attila Mócsai Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form published pages: 3793-3803, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1701803 |
The Journal of Immunology 201/12 | 2020-04-14 |
2019 |
Michael Bonelli, Karolina Dalwigk, Alexander Platzer, Isabel Olmos Calvo, Silvia Hayer, Birgit Niederreiter, Johannes Holinka, Florian Sevelda, Thomas Pap, Günter Steiner, Giulio Superti-Furga, Josef S. Smolen, Hans P. Kiener, Thomas Karonitsch IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes published pages: , ISSN: 1226-3613, DOI: 10.1038/s12276-019-0267-6 |
Experimental & Molecular Medicine 51/7 | 2020-04-14 |
2019 |
Arieke Suzanna Berendina Kampstra, Jacqueline Stephanie Dekkers, Mikhail Volkov, Annemarie L Dorjée, Lise Hafkenscheid, Ayla C Kempers, Myrthe van Delft, Theresa Kissel, Sanne Reijm, George M C Janssen, Peter A van Veelen, Holger Bang, Tom W J Huizinga, Leendert A Trouw, Diane van der Woude, René E M Toes Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification published pages: 908-916, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2018-214950 |
Annals of the Rheumatic Diseases 78/7 | 2020-04-14 |
2019 |
Kristyna Hradilkova, Patrick Maschmeyer, Kerstin Westendorf, Heidi Schliemann, Olena Husak, Anne Sae Lim Stuckrad, Tilmann Kallinich, Kirsten Minden, Pawel Durek, Joachim R. Grün, Hyunâ€Dong Chang, Andreas Radbruch Regulation of Fatty Acid Oxidation by Twist 1 in the Metabolic Adaptation of T Helper Lymphocytes to Chronic Inflammation published pages: , ISSN: 2326-5191, DOI: 10.1002/art.40939 |
Arthritis & Rheumatology | 2020-04-14 |
2019 |
Thomas Wohlfahrt, Simon Rauber, Steffen Uebe, Markus Luber, Alina Soare, Arif Ekici, Stefanie Weber, Alexandru-Emil Matei, Chih-Wei Chen, Christiane Maier, Emmanuel Karouzakis, Hans P. Kiener, Elena Pachera, Clara Dees, Christian Beyer, Christoph Daniel, Kolja Gelse, Andreas E. Kremer, Elisabeth Naschberger, Michael Stürzl, Falk Butter, Michael Sticherling, Susetta Finotto, Alexander Kreuter, Mark H. Kaplan, Astrid Jüngel, Steffen Gay, Stephen L. Nutt, David W. Boykin, Gregory M. K. Poon, Oliver Distler, Georg Schett, Jörg H. W. Distler, Andreas Ramming PU.1 controls fibroblast polarization and tissue fibrosis published pages: 344-349, ISSN: 0028-0836, DOI: 10.1038/s41586-019-0896-x |
Nature 566/7744 | 2020-04-14 |
2018 |
Anita Fischer, Shahla Abdollahi-Roodsaz, Christina Böhm, Birgit Niederreiter, Brigitte Meyer, Anthony C. Y. Yau, Erik Lönnblom, Leo A. B. Joosten, Marije Koenders, Christian H. K. Lehmann, Diana Dudziak, Gerhard Krönke, Rikard Holmdahl, Günter Steiner The involvement of Toll-like receptor 9 in the pathogenesis of erosive autoimmune arthritis published pages: 4399-4409, ISSN: 1582-1838, DOI: 10.1111/jcmm.13735 |
Journal of Cellular and Molecular Medicine 22/9 | 2020-04-14 |
2018 |
Aline Bozec, Yubin Luo, Cecilia Engdahl, Camille Figueiredo, Holger Bang, Georg Schett Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-018-1527-x |
Arthritis Research & Therapy 20/1 | 2020-04-14 |
2018 |
Fabian Stemmler, David Simon, Anna-Maria Liphardt, Matthias Englbrecht, Juergen Rech, Axel J Hueber, Klaus Engelke, Georg Schett, Arnd Kleyer Biomechanical properties of bone are impaired in patients with ACPA-positive rheumatoid arthritis and associated with the occurrence of fractures published pages: 973-980, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2017-212404 |
Annals of the Rheumatic Diseases 77/7 | 2020-04-14 |
2018 |
Tobias Alexander, Qingyu Cheng, Jens Klotsche, Laleh Khodadadi, Aderajew Waka, Robert Biesen, Bimba F. Hoyer, Gerd R. Burmester, Andreas Radbruch, Falk Hiepe Proteasome inhibition with bortezomib induces a therapeutically relevant depletion of plasma cells in SLE but does not target their precursors published pages: 1573-1579, ISSN: 0014-2980, DOI: 10.1002/eji.201847492 |
European Journal of Immunology 48/9 | 2020-04-14 |
2018 |
Cecilia Engdahl, Albert Bondt, Ulrike Harre, Jasmin Raufer, René Pfeifle, Alessandro Camponeschi, Manfred Wuhrer, Michaela Seeling, Inga-Lill Mårtensson, Falk Nimmerjahn, Gerhard Krönke, Hans U. Scherer, Helena Forsblad-d’Elia, Georg Schett Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-018-1586-z |
Arthritis Research & Therapy 20/1 | 2020-04-14 |
2018 |
Daniela Sieghart, Alexander Platzer, Paul Studenic, Farideh Alasti, Maresa Grundhuber, Sascha Swiniarski, Thomas Horn, Helmuth Haslacher, Stephan Blüml, Josef Smolen, Günter Steiner Determination of Autoantibody Isotypes Increases the Sensitivity of Serodiagnostics in Rheumatoid Arthritis published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00876 |
Frontiers in Immunology 9 | 2020-04-14 |
2017 |
Andrew P. Cope Emerging therapies for pre-RA published pages: 99-111, ISSN: 1521-6942, DOI: 10.1016/j.berh.2017.08.005 |
Best Practice & Research Clinical Rheumatology 31/1 | 2020-04-14 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "RTCURE" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "RTCURE" are provided by the European Opendata Portal: CORDIS opendata.
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