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RTCure SIGNED

Rheuma Tolerance for Cure

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

RTCure project word cloud

Explore the words cloud of the RTCure project. It provides you a very rough idea of what is the project "RTCure" about.

sponsored precision stratified standardisation sub phases progress panel treatments cohorts treat inflammation effect arthralgia maturation joint undifferentiated prevention individuals reactions pharma performed imi2 successful mediated tolerance unexplored medicine disseminate trials stages expand drugs prevent monitor disease pain patients autoimmune accomplished standardise investigator goals protocols ultimately pathogenic quality expansion groups clinical purposes initiated proportion ambition tools rheumatic approved ra fatigue interfere companies onset arthritis biomarkers tolerising therapeutic therapies bone inhibiting progression validate line lasting interference company suitable experiences symptoms diseases earlier patient subjects risk immune cure smes life

Project "RTCure" data sheet

The following table provides information about the project.

Coordinator	KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Sweden [SE]
Project website	http://www.rtcure.com
Total cost	13˙846˙865 €
EC max contribution	6˙000˙000 € (43%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2016-09-two-stage
Funding Scheme	IMI2-RIA
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2022-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	coordinator	1˙190˙000.00
2	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	595˙000.00
3	Deutsches Rheuma-Forschungszentrum Berlin Deutsches Rheuma-Forschungszentrum Berlin Organization address address: Chariteplatz 1 city: Berlin postcode: 10117 website: www.drfz.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Berlin)	participant	465˙000.00
4	KING'S COLLEGE LONDON KING'S COLLEGE LONDON Organization address address: STRAND city: LONDON postcode: WC2R 2LS website: www.kcl.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	465˙000.00
5	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	465˙000.00
6	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	participant	465˙000.00
7	UNIVERSITATSKLINIKUM ERLANGEN UNIVERSITATSKLINIKUM ERLANGEN Organization address address: MAXIMILIANSPLATZ 2 city: ERLANGEN postcode: 91054 website: www.uk-erlangen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ERLANGEN)	participant	465˙000.00
8	UNIVERSITY OF GLASGOW UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	participant	465˙000.00
9	UNIVERSITY OF NEWCASTLE UPON TYNE UNIVERSITY OF NEWCASTLE UPON TYNE Organization address address: KINGS GATE city: NEWCASTLE UPON TYNE postcode: NE1 7RU website: http://www.ncl.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (NEWCASTLE UPON TYNE)	participant	465˙000.00
10	THE UNIVERSITY OF QUEENSLAND THE UNIVERSITY OF QUEENSLAND Organization address address: ST LUCIA city: BRISBANE postcode: 4072 website: http://www.uq.edu.au contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AU (BRISBANE)	participant	300˙000.00
11	ANOCCA AB ANOCCA AB Organization address address: FORSKARGATAN 20C city: SODERTALJE postcode: 151 36 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SODERTALJE)	participant	240˙000.00
12	APITOPE INTERNATIONAL NV APITOPE INTERNATIONAL NV Organization address address: AGORALAAN A BIS city: DIEPENBEEK postcode: 3590 website: www.apitope.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (DIEPENBEEK)	participant	240˙000.00
13	SEMMELWEIS EGYETEM SEMMELWEIS EGYETEM Organization address address: ULLOI UTCA 26 city: BUDAPEST postcode: 1085 website: www.sote.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (BUDAPEST)	participant	180˙000.00
14	BRISTOL-MYERS SQUIBB COMPANY CORP BRISTOL-MYERS SQUIBB COMPANY CORP Organization address address: PARK AVENUE 345 city: NEW YORK postcode: 10154 website: http://www.bms.com/landing/data/index.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (NEW YORK)	participant	0.00
15	FONDAZIONE PER L ISTITUTO DI RICERCA IN BIOMEDICINA FONDAZIONE PER L ISTITUTO DI RICERCA IN BIOMEDICINA Organization address address: VIA VINCENZO VELA 6 city: BELLINZONA postcode: 6500 website: http://www.irb.usi.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (BELLINZONA)	participant	0.00
16	GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. Organization address address: Great West Road 980 city: BRENTFORD postcode: TW89GS website: www.gsk.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRENTFORD)	participant	0.00
17	JANSSEN PHARMACEUTICA NV JANSSEN PHARMACEUTICA NV Organization address address: TURNHOUTSEWEG 30 city: BEERSE postcode: 2340 website: www.janssenpharmaceutica.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BEERSE)	participant	0.00
18	PFIZER LIMITED PFIZER LIMITED Organization address address: RAMSGATE ROAD city: SANDWICH postcode: CT13 9NJ website: www.pfizer.co.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SANDWICH)	participant	0.00
19	SANOFI-AVENTIS DEUTSCHLAND GMBH SANOFI-AVENTIS DEUTSCHLAND GMBH Organization address address: BRUNINGSTRASSE 50 city: FRANKFURT AM MAIN postcode: 65929 website: www.sanofi.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	0.00
20	UCB BIOPHARMA SRL UCB BIOPHARMA SRL Organization address address: ALLEE DE LA RECHERCHE 60 city: BRUXELLES postcode: 1070 website: www.ucb.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	0.00

Map

Project objective

In line with IMI2 goals for improved therapies and precision medicine, the aim of this proposal is to prevent and treat RA or its progression by inhibiting maturation/expansion of pathogenic autoimmune responses through immune tolerising treatments of subjects not only in early stages of joint inflammation (undifferentiated arthritis and early RA) but also in even earlier defined stages i.e. before onset of joint inflammation, when patients have arthralgia and/or bone loss, or sub-clinical stages of joint inflammation.

Today, no drugs are approved for these early phases of RA development, where symptoms such as pain and fatigue cause major loss of life quality and where successful interference would prevent onset of disease. Thus, an important part of our work will be to achieve a better understanding of this as yet unexplored phase of disease. In the proposed project we will develop and validate new methods to identify individuals at high risk for RA, tools to monitor disease progress and expand and further develop cohorts suitable for these purposes. Furthermore we will validate and standardise methods to monitor immune tolerance to be used in clinical trials for tolerising therapies for RA. The aim is thus to interfere with the specific immune reactions that contribute to RA symptoms in such a way that a specific and long-lasting therapeutic effect (ultimately a cure) is accomplished for a major proportion of RA patients and prevention of diseases is accomplished in individuals at high risk for RA.

Investigator-initiated as well as company-sponsored clinical trials in well stratified patient groups will be performed in collaboration with SMEs and/or contributing pharma companies and their immune effects studied using the same panel of biomarkers allowing for standardisation across protocols. Our ambition is also to disseminate our experiences from RA to other rheumatic and other immune-mediated diseases.

Deliverables

List of deliverables.
Comparison of serologic features of at-risk individuals and recent onset arthritis patients	Documents, reports	2020-04-14 16:13:06
Optimal participant population(s) for clinical studies of tolerogenic interventions	Documents, reports	2020-04-14 16:13:06
Algorithm for predicting the development of arthritis	Documents, reports	2020-04-14 16:13:06
Key risk predictors for the transition from the at-risk status to clinical arthritis	Documents, reports	2020-04-14 16:13:06
ARIAA Midterm recruitment report	Documents, reports	2020-04-14 16:13:06
Status on ongoing clinical trials in RTCure	Documents, reports	2020-04-14 16:13:05
Arrange thematic workshops in collaboration with the other WPs	Other	2020-04-14 16:13:05
Report on the core data set for characterisation of individuals at-risk for developing RA	Documents, reports	2020-04-14 16:13:05
Build a multidisciplinary task force	Websites, patent fillings, videos etc.	2020-04-14 16:13:05
Set up internal and external website with a RTCure logo	Websites, patent fillings, videos etc.	2020-04-14 16:13:05
Screening and analysis of biological and clinical datasets	Documents, reports	2020-04-14 16:13:05

Take a look to the deliverables list in detail: detailed list of RTCure deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Rachel Spiering, Manon A. A. Jansen, Matthew J. Wood, Anshorulloh A. Fath, Oliver Eltherington, Amy E. Anderson, Arthur G. Pratt, Willem van Eden, John D. Isaacs, Femke Broere, Catharien M. U. Hilkens Targeting of tolerogenic dendritic cells to heat-shock proteins in inflammatory arthritis published pages: , ISSN: 1479-5876, DOI: 10.1186/s12967-019-2128-4	Journal of Translational Medicine 17/1	2020-04-14
2019	Eliana Goncalves-Alves, Victoria Saferding, Christopher Schliehe, Robert Benson, Mariola Kurowska-Stolarska, Julia Stefanie Brunner, Antonia Puchner, Bruno K. Podesser, Josef S. Smolen, Kurt Redlich, Michael Bonelli, James Brewer, Andreas Bergthaler, GÃ¼nter Steiner, Stephan BlÃ¼ml MicroRNA-155 Controls T Helper Cell Activation During Viral Infection published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.01367	Frontiers in Immunology 10	2020-04-14
2019	Theresa Kissel, Karin Anna van Schie, Lise Hafkenscheid, Anders Lundquist, Heidi Kokkonen, Manfred Wuhrer, Tom WJ Huizinga, Hans Ulrich Scherer, RenÃ© Toes, Solbritt RantapÃ¤Ã¤-Dahlqvist On the presence of HLA-SE alleles and ACPA-IgG variable domain glycosylation in the phase preceding the development of rheumatoid arthritis published pages: annrheumdis-2019, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2019-215698	Annals of the Rheumatic Diseases	2020-04-14
2019	Lise Hafkenscheid, Emma Moel, Irene Smolik, Stacey Tanner, Xiaobo Meng, Bas C. Jansen, Albert Bondt, Manfred Wuhrer, Tom W. J. Huizinga, Rene E. M. Toes, Hani Elâ€Gabalawy, Hans U. Scherer N â€Linked Glycans in the Variable Domain of IgG Antiâ€“Citrullinated Protein Antibodies Predict the Development of Rheumatoid Arthritis published pages: 1626-1633, ISSN: 2326-5191, DOI: 10.1002/art.40920	Arthritis & Rheumatology 71/10	2020-04-14
2019	David Simon, Arnd Kleyer, Sara Bayat, Koray Tascilar, Eleni Kampylafka, Timo Meinderink, Louis Schuster, Ramona Petrov, Anna-Maria Liphardt, Juergen Rech, Georg Schett, Axel J. Hueber Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-019-1938-3	Arthritis Research & Therapy 21/1	2020-04-14
2019	TamÃ¡s NÃ©meth, Krisztina Futosi, Marcell SzabÃ³, Petra Aradi, Takashi Saito, Attila MÃ³csai, ZoltÃ¡n Jakus Importance of Fc Receptor Î³-Chain ITAM Tyrosines in Neutrophil Activation and in vivo Autoimmune Arthritis published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.00252	Frontiers in Immunology 10	2020-04-14
2019	Karin Roos Ljungberg, Vijay Joshua, Thomas Skogh, Anders Eklund, C Magnus SkÃ¶ld, Reza Karimi, Sven NyrÃ©n, Anna SvÃ¤rd, Anca I Catrina, Alf Kastbom Secretory anti-citrullinated protein antibodies in serum associate with lung involvement in early rheumatoid arthritis published pages: , ISSN: 1462-0324, DOI: 10.1093/rheumatology/kez377	Rheumatology	2020-04-14
2019	Rochelle D. Vergroesen, Linda M. Slot, Barbera D. C. van Schaik, Marvyn T. Koning, Theo Rispens, Antoine H. C. van Kampen, RenÃ© E. M. Toes, Hans U. Scherer N-Glycosylation Site Analysis of Citrullinated Antigen-Specific B-Cell Receptors Indicates Alternative Selection Pathways During Autoreactive B-Cell Development published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2019.02092	Frontiers in Immunology 10	2020-04-14
2018	Anna Neumann, Judith Haschka, Arnd Kleyer, Louis Schuster, Matthias Englbrecht, Andreas Berlin, Camille P. Figueiredo, David Simon, Christian Muschitz, Roland Kocijan, Heinrich Resch, JÃ¼rgen Rech, Georg Schett Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-018-1620-1	Arthritis Research & Therapy 20/1	2020-04-14
2019	Kaja Eriksson, Guozhong Fei, Anna Lundmark, Daniel Benchimol, Linkiat Lee, Yue O. O. Hu, Anna Kats, Saedis Saevarsdottir, Anca Irinel Catrina, BjÃ¶rn Klinge, Anders F. Andersson, Lars Klareskog, Karin Lundberg, Leif Jansson, TÃ¼lay Yucel-Lindberg Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis published pages: 630, ISSN: 2077-0383, DOI: 10.3390/jcm8050630	Journal of Clinical Medicine 8/5	2020-04-14
2019	Esperanza Perucha, Rossella Melchiotti, Jack A Bibby, Wing Wu, Klaus Stensgaard Frederiksen, Ceri A. Roberts, Zoe Hall, Gaelle LeFriec, Kevin A. Robertson, Paul Lavender, Jens Gammeltoft Gerwien, Leonie S. Taams, Julian L. Griffin, Emanuele de Rinaldis, Lisa G. M. van Baarsen, Claudia Kemper, Peter Ghazal, Andrew P. Cope The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-08332-9	Nature Communications 10/1	2020-04-14
2019	Meng Sun, Bence Rethi, Akilan Krishnamurthy, Vijay Joshua, Alexandra Circiumaru, Aase Haj Hensvold, Elena Ossipova, Caroline GrÃ¶nwall, Yanying Liu, Marianne Engstrom, Sergiu Bogdan Catrina, Johanna Steen, Vivianne Malmstrom, Lars Klareskog, Camilla Svensson, Caroline Ospelt, Heidi WÃ¤hÃ¤maa, Anca Irinel Catrina Anticitrullinated protein antibodies facilitate migration of synovial tissue-derived fibroblasts published pages: annrheumdis-2018, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2018-214967	Annals of the Rheumatic Diseases	2020-04-14
2018	Lianne P. W. M. Lelieveldt, Hendy Kristyanto, Ger J. M. Pruijn, Hans Ulrich Scherer, RenÃ© E. M. Toes, Kimberly M. Bonger Sequential Prodrug Strategy To Target and Eliminate ACPA-Selective Autoreactive B Cells published pages: 5565-5573, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.8b00741	Molecular Pharmaceutics 15/12	2020-04-14
2018	David Simon, Arnd Kleyer, Francesca Faustini, Matthias Englbrecht, Judith Haschka, Andreas Berlin, Sebastian Kraus, Axel J. Hueber, Roland Kocijan, Michael Sticherling, Juergen Rech, Georg Schett Simultaneous quantification of bone erosions and enthesiophytes in the joints of patients with psoriasis or psoriatic arthritis - effects of age and disease duration published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-018-1691-z	Arthritis Research & Therapy 20/1	2020-04-14
2019	P. Wehr, H. Purvis, S.â€C. Law, R. Thomas Dendritic cells, T cells and their interaction in rheumatoid arthritis published pages: 12-27, ISSN: 0009-9104, DOI: 10.1111/cei.13256	Clinical & Experimental Immunology 196/1	2020-04-14
2019	Andrew P. Cope Considerations for Optimal Trial Design for Rheumatoid Arthritis Prevention Studies published pages: 1299-1311, ISSN: 0149-2918, DOI: 10.1016/j.clinthera.2019.04.014	Clinical Therapeutics 41/7	2020-04-14
2019	Eleni Kampylafka, David Simon, Isabelle dâ€™Oliveira, Christina Linz, Veronika Lerchen, Matthias Englbrecht, Juergen Rech, Arnd Kleyer, Michael Sticherling, Georg Schett, Axel J. Hueber Disease interception with interleukin-17 inhibition in high-risk psoriasis patients with subclinical joint inflammationâ€”data from the prospective IVEPSA study published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-019-1957-0	Arthritis Research & Therapy 21/1	2020-04-14
2018	Janka ZsÃ³fia Csepregi, Anita Orosz, Erik Zajta, Orsolya KÃ¡sa, TamÃ¡s NÃ©meth, Edina Simon, Szabina Fodor, Katalin Csonka, BalÃ¡zs L. BarÃ¡tki, Dorottya KÃ¶vesdi, You-Wen He, Attila GÃ¡cser, Attila MÃ³csai Myeloid-Specific Deletion of Mcl-1 Yields Severely Neutropenic Mice That Survive and Breed in Homozygous Form published pages: 3793-3803, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1701803	The Journal of Immunology 201/12	2020-04-14
2019	Michael Bonelli, Karolina Dalwigk, Alexander Platzer, Isabel Olmos Calvo, Silvia Hayer, Birgit Niederreiter, Johannes Holinka, Florian Sevelda, Thomas Pap, GÃ¼nter Steiner, Giulio Superti-Furga, Josef S. Smolen, Hans P. Kiener, Thomas Karonitsch IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes published pages: , ISSN: 1226-3613, DOI: 10.1038/s12276-019-0267-6	Experimental & Molecular Medicine 51/7	2020-04-14
2019	Arieke Suzanna Berendina Kampstra, Jacqueline Stephanie Dekkers, Mikhail Volkov, Annemarie L DorjÃ©e, Lise Hafkenscheid, Ayla C Kempers, Myrthe van Delft, Theresa Kissel, Sanne Reijm, George M C Janssen, Peter A van Veelen, Holger Bang, Tom W J Huizinga, Leendert A Trouw, Diane van der Woude, RenÃ© E M Toes Different classes of anti-modified protein antibodies are induced on exposure to antigens expressing only one type of modification published pages: 908-916, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2018-214950	Annals of the Rheumatic Diseases 78/7	2020-04-14
2019	Kristyna Hradilkova, Patrick Maschmeyer, Kerstin Westendorf, Heidi Schliemann, Olena Husak, Anne Sae Lim Stuckrad, Tilmann Kallinich, Kirsten Minden, Pawel Durek, Joachim R. GrÃ¼n, Hyunâ€Dong Chang, Andreas Radbruch Regulation of Fatty Acid Oxidation by Twist 1 in the Metabolic Adaptation of T Helper Lymphocytes to Chronic Inflammation published pages: , ISSN: 2326-5191, DOI: 10.1002/art.40939	Arthritis & Rheumatology	2020-04-14
2019	Thomas Wohlfahrt, Simon Rauber, Steffen Uebe, Markus Luber, Alina Soare, Arif Ekici, Stefanie Weber, Alexandru-Emil Matei, Chih-Wei Chen, Christiane Maier, Emmanuel Karouzakis, Hans P. Kiener, Elena Pachera, Clara Dees, Christian Beyer, Christoph Daniel, Kolja Gelse, Andreas E. Kremer, Elisabeth Naschberger, Michael StÃ¼rzl, Falk Butter, Michael Sticherling, Susetta Finotto, Alexander Kreuter, Mark H. Kaplan, Astrid JÃ¼ngel, Steffen Gay, Stephen L. Nutt, David W. Boykin, Gregory M. K. Poon, Oliver Distler, Georg Schett, JÃ¶rg H. W. Distler, Andreas Ramming PU.1 controls fibroblast polarization and tissue fibrosis published pages: 344-349, ISSN: 0028-0836, DOI: 10.1038/s41586-019-0896-x	Nature 566/7744	2020-04-14
2018	Anita Fischer, Shahla Abdollahi-Roodsaz, Christina BÃ¶hm, Birgit Niederreiter, Brigitte Meyer, Anthony C. Y. Yau, Erik LÃ¶nnblom, Leo A. B. Joosten, Marije Koenders, Christian H. K. Lehmann, Diana Dudziak, Gerhard KrÃ¶nke, Rikard Holmdahl, GÃ¼nter Steiner The involvement of Toll-like receptor 9 in the pathogenesis of erosive autoimmune arthritis published pages: 4399-4409, ISSN: 1582-1838, DOI: 10.1111/jcmm.13735	Journal of Cellular and Molecular Medicine 22/9	2020-04-14
2018	Aline Bozec, Yubin Luo, Cecilia Engdahl, Camille Figueiredo, Holger Bang, Georg Schett Abatacept blocks anti-citrullinated protein antibody and rheumatoid factorÂ mediated cytokine production in human macrophages in IDO-dependent manner published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-018-1527-x	Arthritis Research & Therapy 20/1	2020-04-14
2018	Fabian Stemmler, David Simon, Anna-Maria Liphardt, Matthias Englbrecht, Juergen Rech, Axel J Hueber, Klaus Engelke, Georg Schett, Arnd Kleyer Biomechanical properties of bone are impaired in patients with ACPA-positive rheumatoid arthritis and associated with the occurrence of fractures published pages: 973-980, ISSN: 0003-4967, DOI: 10.1136/annrheumdis-2017-212404	Annals of the Rheumatic Diseases 77/7	2020-04-14
2018	Tobias Alexander, Qingyu Cheng, Jens Klotsche, Laleh Khodadadi, Aderajew Waka, Robert Biesen, Bimba F. Hoyer, Gerd R. Burmester, Andreas Radbruch, Falk Hiepe Proteasome inhibition with bortezomib induces a therapeutically relevant depletion of plasma cells in SLE but does not target their precursors published pages: 1573-1579, ISSN: 0014-2980, DOI: 10.1002/eji.201847492	European Journal of Immunology 48/9	2020-04-14
2018	Cecilia Engdahl, Albert Bondt, Ulrike Harre, Jasmin Raufer, RenÃ© Pfeifle, Alessandro Camponeschi, Manfred Wuhrer, Michaela Seeling, Inga-Lill MÃ¥rtensson, Falk Nimmerjahn, Gerhard KrÃ¶nke, Hans U. Scherer, Helena Forsblad-dâ€™Elia, Georg Schett Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women published pages: , ISSN: 1478-6362, DOI: 10.1186/s13075-018-1586-z	Arthritis Research & Therapy 20/1	2020-04-14
2018	Daniela Sieghart, Alexander Platzer, Paul Studenic, Farideh Alasti, Maresa Grundhuber, Sascha Swiniarski, Thomas Horn, Helmuth Haslacher, Stephan BlÃ¼ml, Josef Smolen, GÃ¼nter Steiner Determination of Autoantibody Isotypes Increases the Sensitivity of Serodiagnostics in Rheumatoid Arthritis published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00876	Frontiers in Immunology 9	2020-04-14
2017	Andrew P. Cope Emerging therapies for pre-RA published pages: 99-111, ISSN: 1521-6942, DOI: 10.1016/j.berh.2017.08.005	Best Practice & Research Clinical Rheumatology 31/1	2020-04-14

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The information about "RTCURE" are provided by the European Opendata Portal: CORDIS opendata.

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