Multicellularity SIGNED
The genetic basis of the convergent evolution of fungal multicellularity
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Project "Multicellularity" data sheet
The following table provides information about the project.
| Coordinator |
SZEGEDI BIOLOGIAI KUTATOKOZPONT
Organization address contact info |
| Coordinator Country | Hungary [HU] |
| Project website | http://group.szbk.u-szeged.hu/sysbiol/nagy-laszlo-lab-index.html |
| Total cost | 1˙486˙500 € |
| EC max contribution | 1˙486˙500 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-01-01 to 2022-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | SZEGEDI BIOLOGIAI KUTATOKOZPONT | HU (SZEGED) | coordinator | 1˙486˙500.00 |
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Project objective
The evolution of multicellularity (MC) has been one of the major transitions in the history of life. Despite immense interest in its evolutionary origins, the genomic changes leading to the emergence of MC, especially that of complex MC (differentiated 3-dimensional structures) are poorly known. Previous comparative genomics projects aiming to understand the genetic bases of MC in one way or another relied on gene content-based analyses. However, a pattern emerging from these studies is that gene content provides only an incomplete explanation for the evolution of MC even at ancient timescales. We hypothesize that besides gene duplications, changes to cis-regulatory elements and gene expression patterns (including protein isoforms) have significantly contributed to the evolution of MC. To test this hypothesis, we will deploy a combination of computational methods, phylogenomics, comparative transcriptomics and genome-wide assays of regulatory elements. Our research focuses on fungi as a model system, where complex MC evolved convergently and in subsequent two steps. Fungi are ideal models to tackle this question for several reasons: a) multicellularity in fungi evolved multiple times, b) there are rich genomic resources (>500 complete genomes), c) complex multicellular structures can be routinely grown in the lab and d) genetic manipulations are feasible for several cornerstone species. We set out to examine which genes participate in the building of simple and complex multicellular structures and whether the evolution of regulome complexity and gene expression patterns can explain the evolution of MC better than can traditionally assayed sources of genetic innovations (e.g. gene duplications). Ultimately, our goal is to reach a general synthesis on the genetic bases of the evolution of MC and that of organismal complexity.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Varga T., Krizsan K., Szarkandi GJ, Dima B., Kiss B., Foldi Cs., Sanchez-Garcia M., Sanchez-Ramirez S., Szollosi GJ., M., Hibbett DS., Vagvolgyi Cs., Papp T., Nagy GL. Understanding the evolution of mushroom-forming fungi: macro-evolutionary analyses of a 5300-species phylogeny of Agaricomycetes. published pages: p.104., ISSN: , DOI: |
14th European Conference on Fungal Genetics 25-28. February. 2018. | 2019-10-15 |
| 2019 |
Krisztina Krizsán, Éva Almási, Zsolt Merényi, Neha Sahu, Máté Virágh, Tamás Kószó, Stephen Mondo, Brigitta Kiss, Balázs Bálint, Ursula Kües, Kerrie Barry, Judit Cseklye, Botond Hegedüs, Bernard Henrissat, Jenifer Johnson, Anna Lipzen, Robin A. Ohm, István Nagy, Jasmyn Pangilinan, Juying Yan, Yi Xiong, Igor V. Grigoriev, David S. Hibbett, László G. Nagy Transcriptomic atlas of mushroom development reveals conserved genes behind complex multicellularity in fungi published pages: 7409-7418, ISSN: 0027-8424, DOI: 10.1073/pnas.1817822116 |
Proceedings of the National Academy of Sciences 116/15 | 2019-10-15 |
| 2019 |
Varga T., Balint B., Merenyi Zs., Grigoriev IV., Nagy GL. COMPARE1K+, a bioinformatic pipeline and an R package to analyse the evolution of thousands of genomes published pages: p.245., ISSN: , DOI: |
Hungarian Molecular Life Science 29-31. March. 2019. | 2019-10-15 |
| 2019 |
Merenyi Zs., Prasanna AN., Wang Z., Kovacs K., Hegedus B., Balint B., Papp B., Townsend JP., Nagy GL Unmatched level of molecular convergence among deeply divergent complex multicellular fungi. published pages: , ISSN: , DOI: |
EVOLUTION of COMPLEX LIFE 15-17. May 2019. | 2019-10-15 |
| 2019 |
Balint B., Merenyi Zs., Varga T., Grigoriev IV., Nagy GL. Evolutionary analysis of thousands of genomes with COMPARE1K+. published pages: , ISSN: , DOI: |
NeLLi – Symposium on New Lineages of Life 2-3. April 2019. | 2019-10-15 |
| 2018 |
Merenyi Zs., Prasanna AN., Almasi E., Krizsan K., Nagy GL. The Origins of Complex Multicellularity in Agarico- and Pezizomycotina. published pages: , ISSN: , DOI: |
A Magyar Mikrobiológiai Társaság 2018. évi Nagygyűlése és a XIII. Fermentációs Kollokvium 17-19. October 2018 | 2019-10-15 |
| 2018 |
Claude Murat, Thibaut Payen, Benjamin Noel, Alan Kuo, Emmanuelle Morin, Juan Chen, Annegret Kohler, Krisztina Krizsán, Raffaella Balestrini, Corinne Da Silva, Barbara Montanini, Mathieu Hainaut, Elisabetta Levati, Kerrie W. Barry, Beatrice Belfiori, Nicolas Cichocki, Alicia Clum, Rhyan B. Dockter, Laure Fauchery, Julie Guy, Mirco Iotti, François Le Tacon, Erika A. Lindquist, Anna Lipzen, Fabienn Pezizomycetes genomes reveal the molecular basis of ectomycorrhizal truffle lifestyle published pages: 1956-1965, ISSN: 2397-334X, DOI: 10.1038/s41559-018-0710-4 |
Nature Ecology & Evolution 2/12 | 2019-10-15 |
| 2018 |
Nagy, GL. Many roads to convergence published pages: 125-126, ISSN: 0036-8075, DOI: 10.1126/science.aau2409 |
Science 361/6398 | 2019-10-15 |
| 2019 |
Kiss E., Hegedus B., Varga T., Merenyi Zs., Balint B., Koszo T., Krizsan K., Prasanna AN., Nagy GL. Comparative genomics reveals the origin of hyphal morphogenesis and fungal multicellularity. published pages: p.15., ISSN: , DOI: |
30th Fungal Genetics Conference 12-17. March. 2019. | 2019-10-15 |
| 2019 |
Kiss, E., Hegedus, B., Varga, T., Merenyi, Z., Koszo, T., Balint, B., Prasanna, AN., Krizsan K., Riquelme, M., Takeshita, N., Nagy, LG. Comparative genomics reveals the origin of fungal hyphae and multicellularity published pages: , ISSN: 2041-1723, DOI: 10.1101/546531 |
Nature Communications | 2019-10-15 |
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