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CHANNELMAT SIGNED

Microchannels for controlling cellular mechanotransduction

Total Cost €

EC-Contrib. €

Partnership

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CHANNELMAT project word cloud

Explore the words cloud of the CHANNELMAT project. It provides you a very rough idea of what is the project "CHANNELMAT" about.

sterilized mechanotransduction porous 15166793 biocompatible cellinspired mechanical structures micron matrix biomaterials materials density migration interconnectivity porosities pct likewise adhesion cell channels demonstrator validate stiffness microporous differentiation ep2016 patent cardiac contains mechanism environment activate dysfunctions diseases cultures receive contact complexity throughput proliferation 3d outcome implant cancer provides serves license environments activation expressed natural represented commercialization surface mimicking guarantees procedure ep commercial fabricated size material pore external platform fabrication form 060160 area dimensions companies cells stimuli modification sized erc levels independently polymer cellular dimensionally

Project "CHANNELMAT" data sheet

The following table provides information about the project.

Coordinator	CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL Organization address address: OLSHAUSENSTRASSE 40 city: KIEL postcode: 24118 website: http://www.uni-kiel.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-PoC
Funding Scheme	ERC-POC
Starting year	2017
Duration (year-month-day)	from 2017-10-01 to 2019-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL Organization address address: OLSHAUSENSTRASSE 40 city: KIEL postcode: 24118 website: http://www.uni-kiel.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KIEL)	coordinator	150˙000.00

Map

Project objective

Cells respond to external mechanical stimuli through an activation of a cellular mechanism called mechanotransduction. The cellular responses in this mechanism are expressed by a modification in cellular proliferation, migration and differentiation, as well as in a strengthening of their adhesion. Likewise, diseases such as cancer and cardiac dysfunctions are also related to cellular mechanotransduction. Here we propose to take a novel 3D material porous material towards commercial applications. The material serves as a platform for controlling mechanotransduction (e.g. in implant materials) and enables a control of mechanotransduction by mimicking natural 3D cellular environments. Our material contains a novel form of microporous structures represented by micron-sized channels embedded in a polymer matrix of a well-defined stiffness that has been developed within the ERC project CELLINSPIRED. The material guarantees pore interconnectivity independently of pore density and size, a unique feature offered by our fabrication procedure, for which we have applied for a patent (EP 15166793.8, PCT/EP2016/060160). Furthermore, it also provides a large, three-dimensionally controlled cell-surface contact area, such that the mechanical properties of the environment will have large impact on the cells. Our goal in this project is to validate our novel material for cellular applications where mechanotransduction is targeted. The expected outcome of our project is to receive a demonstrator material that (1) has well-defined mechanical properties, porosities and pore dimensions, (2) is biocompatible and can be sterilized, (3) can be fabricated in different levels of complexity, (4) can activate mechanotransduction in cells, and (5) can be fabricated using high-throughput processes. As for commercialization, we aim to license the patent to biomaterials companies involved in applications that range from 3D cell cultures to implant materials.

Publications

List of publications.
year	authors and title	journal	last update
2019	Mohammadreza Taale, Fabian SchÃ¼tt, Tian Carey, Janik Marx, Yogendra Kumar Mishra, Norbert Stock, Bodo Fiedler, Felice Torrisi, Rainer Adelung, Christine Selhuber-Unkel Biomimetic Carbon Fiber Systems Engineering: A Modular Design Strategy To Generate Biofunctional Composites from Graphene and Carbon Nanofibers published pages: 5325-5335, ISSN: 1944-8244, DOI: 10.1021/acsami.8b17627	ACS Applied Materials & Interfaces 11/5	2019-06-06
2019	SÃ¶ren B. Gutekunst, Katharina Siemsen, Steven Huth, Anneke MÃ¶hring, Britta Hesseler, Michael Timmermann, Ingo Paulowicz, Yogendra Kumar Mishra, Leonard Siebert, Rainer Adelung, Christine Selhuber-Unkel 3D Hydrogels Containing Interconnected Microchannels of Subcellular Size for Capturing Human Pathogenic Acanthamoeba Castellanii published pages: 1784-1792, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.8b01009	ACS Biomaterials Science & Engineering 5/4	2019-06-06

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The information about "CHANNELMAT" are provided by the European Opendata Portal: CORDIS opendata.