Explore the words cloud of the EDIReX project. It provides you a very rough idea of what is the project "EDIReX" about.
The following table provides information about the project.
Coordinator |
UNIVERSITA DEGLI STUDI DI TORINO
Organization address contact info |
Coordinator Country | Italy [IT] |
Project website | http://www.europdx.eu |
Total cost | 5˙156˙198 € |
EC max contribution | 5˙156˙198 € (100%) |
Programme |
1. H2020-EU.1.4.1.2. (Integrating and opening existing national and regional research infrastructures of European interest) |
Code Call | H2020-INFRAIA-2017-1-two-stage |
Funding Scheme | RIA |
Starting year | 2018 |
Duration (year-month-day) | from 2018-02-01 to 2022-01-31 |
Take a look of project's partnership.
Counteracting high attrition rates in oncology drug development and providing optimal therapeutic management of cancer patients require preclinical models that properly recapitulate the complexity and diversity of human tumours. Patient-derived tumour xenografts (PDXs), established by transplanting tumour fragments into immunodeficient mice, are being widely embraced by the scientific community as preclinical tools for target and biomarker discovery. The overall goal of EDIReX is to establish a cutting-edge European infrastructure offering Trans-national Access (TA) of PDX resources to academic and industrial cancer researchers, including the distribution of cryopreserved samples to third parties, the structured biobanking of user-developed models, and the performance of efficacy studies. To ensure interoperability in services, TA initiatives will be backed by Networking Activities (NAs); these will be mainly centred around the establishment of standard procedures for PDX quality control, long-term storage and therapeutic mouse trials. NAs will also entail the adoption of shared ethics parameters for animal experimentation, the wide dissemination of services and project results, and the design of plans to ensure sustainability of the infrastructure. User outreach will be maximised by Joint Research Activities through a three-pronged approach: i) the implementation of a public Data Portal for efficient and user-friendly query and visualisation of clinical, molecular and pharmacological annotation of the models; ii) a cross-validation mouse trial to harmonise inter-laboratory procedures, thus improving the quality and reliability of service provision; and iii) the development of exploratory, more advanced PDX-based preclinical platforms, such as orthotopic and humanised models and in vitro PDX-derived cells. Capitalising on all these assets, EDIReX will contribute to structuring the European Research Area and global cooperation of research infrastructures.
Outline of the information recorded in a “PDX Passport†| Documents, reports | 2020-03-18 19:01:26 |
Take a look to the deliverables list in detail: detailed list of EDIReX deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Enzo Medico, Emilie Vinolo EurOPDX Data Portal: a repository of patient-derived xenograft models published pages: , ISSN: , DOI: 10.6019/tol.europdx-w.2019.00001.1 |
Webinar | 2020-03-18 |
2019 |
Simona Corso, Claudio Isella, Sara E Bellomo, Maria Apicella, Stefania Durando, Cristina Migliore, Stefano Ughetto, Laura D\'Errico, Silvia Menegon, Daniel Moya-Rull, Marilisa Cargnelutti, Tania Capeloa, Daniela Conticelli, Jessica Giordano, Tiziana Venesio, Antonella Balsamo, Caterina Marchiò, Maurizio Degiuli, Rossella Reddavid, Uberto Fumagalli Romario, Stefano de Pascale, Giovanni Sgroi, Emanu A comprehensive PDX gastric cancer collection captures cancer cell intrinsic transcriptional MSI traits. published pages: canres.1166.2019, ISSN: 0008-5472, DOI: 10.1158/0008-5472.can-19-1166 |
Cancer Research | 2020-03-18 |
2019 |
Sander Basten, Bram Herpers, Kuan Yan, Julia Schueler, Leo S. Price Patient-derived 3D tumor cultures for compound screening and pre-clinical drug development published pages: , ISSN: , DOI: |
AACR Annual Meeting 2019 Online Proceedings | 2020-03-18 |
2019 |
Andrea Mignone, Alberto Grand, Alessandro Fiori, Enzo Medico, Andrea Bertotti Semalytics: a semantic analytics platform for the exploration of distributed and heterogeneous cancer data in translational research published pages: , ISSN: 1758-0463, DOI: 10.1093/database/baz080 |
Database 2019 | 2020-03-18 |
2018 |
E. Vinolo1, J.P. Morris1, A. Bruna2, A.T. Byrne3, R.B. Clarke4, S. de Jong5, J. Jonkers6, A. Krenek7, G.M. Maelandsmo8, M.T. Mayrhofer9, T.F. Meehan10, P.G. Pelicci11, A. Piris-Gimenez12, L. Price13, L. Rizzotto14, S. Roman-Roman15, F. Sarno16, L. Vezzadini17, A. Villanueva18, E. Medico19.
1Seeding Science SPRL, Limelette, Belgium; 2Cancer Research UK Cambridge Institute, Cambridge Cancer Centre, University of Cambridge, Cambridge, United Kingdom; 3Royal College of Surgeons in Ireland, Physiology & Medical Physics Dept, Dublin, Ireland; 4Manchester Cancer Research Centre, University of Manchester, Breast Biology Group, Division of Cancer Sciences, Manchester, United Kingdom; 5University Medical Centre Groningen, University of Groningen, Medical Oncology, Cancer Research Centre Groningen, Groningen, Netherlands; 6The Netherlands Cancer Institute, Division of Molecular Pathology, Oncode Institute, Amsterdam, Netherlands; 7Masarykova Univerzita, Institute of Computer Science, Brno, Czech Republic; 8Oslo University Hospital, Institute for Cancer Research, Oslo, Norway; 9Biobanking and BioMolecular resources Research Infrastructure, European Research Infrastructure Consortium, Graz, Austria; 10European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom; 11European Institute of Oncology, Department of Experimental Oncology, Milan, Italy; 12Vall d’Hebron Institute of Oncology and CIBERONC, Barcelona, Spain; 13Ocello bv, Leiden, Netherlands; 14Katholieke Universiteit Leuven, TRACE PDTX Platform, Leuven, Belgium; 15Institut Curie, PSL Research University, Department of Translational Research, Paris, France; 16Hospital de Fuenlabrada, Department of Medical Oncology, Fuenlabrada, Spain; 17Kairos3D srl, Turin, Italy; 18Catalan Institute of Oncology ICO, Bellvitge Biomedical Research Institute IDIBELL, Chemoresistance and Predictive Factors Laboratory, ProCURE, L’Hospitalet de Llobregat, Barcelona, Spain; 19University of Torino, Candiolo Cancer Institute IRCCS and Department of Oncology, Turin, Italy The EurOPDX EDIReX project: towards a European Research Infrastructure on patient-derived cancer models published pages: 118, ISSN: 0959-8049, DOI: |
European Journal of Cancer Volume 103S1, November 2018 | 2020-03-18 |
2018 |
E. Medico, M.Bentires-Alj, A. V. Biankin, A. Bruna, A. T. Byrne, C. Caldas, R. B. Clarke, G. Coukos, O. Elemento, M. Hidalgo, G. Inghirami, S. de Jong, J. Jonkers, A. Krenek, E. Leucci, G. M. Maelandsmo, M. Th. Mayrhofer, T. F. Meehan, S. P. Niclou, P. G. Pelicci, A. Piris-Gimenez, L. Price, S. Roman-Roman, L. Trusolino, L. Vezzadini, A. Villanueva, E. Vinolo. The EurOPDX EDIReX project: Towards a European research infrastructure on patient-derived cancer models published pages: , ISSN: , DOI: |
AACR Annual Meeting 2018 Online Proceedings | 2020-03-18 |
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