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MOODSTRATIFICATION SIGNED

Immune Signatures for Therapy Stratification in Major Mood Disorders

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

MOODSTRATIFICATION project word cloud

Explore the words cloud of the MOODSTRATIFICATION project. It provides you a very rough idea of what is the project "MOODSTRATIFICATION" about.

basis objective easily efficacy male technologies ready psychiatrists causal poor contributor 50 modulators made therapies firstly considerably depression psychiatry inflammation integrates therapeutic computational uses countries brings associations combinations validated 11 chronic analytes novelty relatively mood stratifying mild patient highest 90 diseases industry data worldwide enforcing facs enforcement international immunologists 20 network conventional patients profiles anti clinical clinic episodes female refine found laboratory collected small moodstratification defects kits omics stratification lab serum multidimensional analyte industries plan therapy depressive disability depressant leukocyte lived longitudinal cell first panel inflammatory national disorders episode proof newly delivered material prevalence differences 12 epidemiologists immune thereafter rates biobank pcr actively paxgene

Project "MOODSTRATIFICATION" data sheet

The following table provides information about the project.

Coordinator	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://www.moodstratification.eu
Total cost	5˙963˙750 €
EC max contribution	5˙963˙750 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2017-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2022-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	coordinator	1˙066˙250.00
2	ASSISTANCE PUBLIQUE HOPITAUX DE PARIS ASSISTANCE PUBLIQUE HOPITAUX DE PARIS Organization address address: 3 AVENUE VICTORIA city: PARIS postcode: 75000 website: http://www.aphp.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	688˙125.00
3	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	623˙500.00
4	OSPEDALE SAN RAFFAELE SRL OSPEDALE SAN RAFFAELE SRL Organization address address: VIA OLGETTINA 60 city: MILANO postcode: 20132 website: www.hsr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	486˙562.00
5	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	participant	480˙500.00
6	ACADEMISCH ZIEKENHUIS GRONINGEN ACADEMISCH ZIEKENHUIS GRONINGEN Organization address address: HANZEPLEIN 1 city: GRONINGEN postcode: 9713 GZ website: www.umcg.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	471˙750.00
7	PRONTO DIAGNOSTICS LTD PRONTO DIAGNOSTICS LTD Organization address address: KIRYAT ATIDIM BUILDING 3 2ND ENTRANCE city: TEL AVIV postcode: 6158002 website: www.prontodiagnostics.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (TEL AVIV)	participant	460˙000.00
8	ADVANCED PRACTICAL DIAGNOSTICS ADVANCED PRACTICAL DIAGNOSTICS Organization address address: RAADSHERENSTRAAT 3 city: TURNHOUT postcode: 2300 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (TURNHOUT)	participant	446˙500.00
9	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Organization address address: SCHLOSSPLATZ 2 city: MUENSTER postcode: 48149 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	participant	428˙750.00
10	UNIVERSITAET ULM UNIVERSITAET ULM Organization address address: HELMHOLTZSTRASSE 16 city: ULM postcode: 89081 website: www.uni-ulm.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ULM)	participant	411˙500.00
11	ILTOO PHARMA ILTOO PHARMA Organization address address: 47/83 BOULEVARD DE L'HOPITAL city: PARIS postcode: 75013 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	299˙062.00
12	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	101˙250.00

Map

Project objective

Objective: MOODSTRATIFICATION brings together 11 partners (psychiatrists, immunologists, epidemiologists, industry) from 7 countries stratifying patients with a major depressive episode on the basis of leukocyte immune profiles. The immune profiles were found in two previous EU projects, which also delivered the novel concept, that T cell defects with episodes of chronic mild inflammation are a causal factor for a large part of mood disorders. The immune profiles determine therapy choice with (combinations of) conventional and novel therapies with immune modulators (e.g. anti-inflammatory and T cell enforcement therapies). On the basis of recent data we expect that the present poor response rates of about 50% to anti-depressant therapy will improve considerably to 80-90%. Mood disorders are complex diseases with a high prevalence (12-20%) and are the second highest contributor to the number of years lived with disability worldwide. Work plan: MOODSTRATIFICATION firstly uses the large data sets and biobank of the two previous EU projects to further refine the already found immune profiles. Therefore the proposal further integrates existing and newly collected multidimensional, longitudinal clinical and laboratory data (-omics, FACS and serum multi-analytes) from these projects for further immune network analysis and computational modelling also taking female-male differences into account. Technologies to easily determine the immune profiles (a relatively small multi-analyte panel, Q-PCR kits on PAXGENE material) will together with industries be developed. Thereafter the efficacy of two novel T cell enforcing therapeutic approaches and the new concept of depression stratification on the basis of the immune profiles will be validated in three clinical proof-of-principle studies. Various national and international patient associations will be actively involved. Novelty: This is the first lab-based therapy stratification in psychiatry made ready for the clinic.

Deliverables

List of deliverables.
Website update M18	Websites, patent fillings, videos etc.	2020-02-18 10:25:18
Website update M12	Websites, patent fillings, videos etc.	2020-02-18 10:25:18
Data management plan	Documents, reports	2020-02-18 10:25:18
Website update M1	Websites, patent fillings, videos etc.	2020-02-18 10:25:18
Website update M6	Websites, patent fillings, videos etc.	2020-02-18 10:25:18
Kick off report	Documents, reports	2020-02-18 10:25:18

Take a look to the deliverables list in detail: detailed list of MOODSTRATIFICATION deliverables.

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The information about "MOODSTRATIFICATION" are provided by the European Opendata Portal: CORDIS opendata.

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