Explore the words cloud of the TissueLymphoContexts project. It provides you a very rough idea of what is the project "TissueLymphoContexts" about.
The following table provides information about the project.
Coordinator |
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
Organization address contact info |
Coordinator Country | Germany [DE] |
Total cost | 1˙498˙750 € |
EC max contribution | 1˙498˙750 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2017-STG |
Funding Scheme | ERC-STG |
Starting year | 2018 |
Duration (year-month-day) | from 2018-03-01 to 2023-02-28 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG | DE (WUERZBURG) | coordinator | 1˙498˙750.00 |
Most anatomical compartments, including mucosal barrier surfaces, solid organs and vascular spaces host different types of tissue-resident lymphocytes providing local networks for immune surveillance and front-line defense to microbial invasion. In addition to immediate effector functions, tissue-resident lymphocytes orchestrate and regulate inflammatory responses, and contribute to tissue homeostasis, repair and barrier function. Understanding the generation and function of tissue-resident lymphocytes is therefore expected to reveal targets for improving vaccination and immunotherapy. Barrier tissues of free-living mice and men, but not those of laboratory mice kept under specific pathogen free conditions, are continuously exposed to an array of antigenically complex pathogens, microbial symbionts and environmental factors, which dramatically alter the abundance, composition and basal activation state of local pools of tissue-resident cells. Therefore, we propose to study the development, functions and cellular interactions of tissue-resident lymphocytes in experimental models that mirror “real-life” contexts. First, we will investigate how polyclonal pools of tissue-resident memory CD8 T cells (TRMs) are established during infection with antigenically complex pathogens. Second, we will restore physiologic exposure to specific pathogens and induce alterations of local microbiota in SPF mice, in order to investigate the induction, function and local interactions of tissue-resident lymphocytes in physiologic tissue environments. In addition, we will explore targeted microbial exposure as a „vaccination“ strategy to induce „non-canonical“ tissue-resident cells in the lung in order to improve protection against infections with multi-resistant bacteria representing major clinical problems in hospitalized patients. In summary, we will investigate fundamental mechanisms of tissue immunity and vaccination in contexts relevant for human physiology and disease.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TISSUELYMPHOCONTEXTS" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "TISSUELYMPHOCONTEXTS" are provided by the European Opendata Portal: CORDIS opendata.