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TissueLymphoContexts SIGNED

Tissue-resident Lymphocytes: Development and Function in “real-life” Contexts

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TissueLymphoContexts project word cloud

Explore the words cloud of the TissueLymphoContexts project. It provides you a very rough idea of what is the project "TissueLymphoContexts" about.

line    living    anatomical    induction    cellular    resident    invasion    life    kept    resistant    strategy    protection    induce    summary    composition    solid    basal    pathogens    mirror    surveillance    cells    lymphocytes    mice    pathogen    polyclonal    mucosal    local    regulate    models    organs    environments    fundamental    defense    tissue    lung    spaces    surfaces    networks    exposed    barrier    front    men    dramatically    host    most    microbiota    functions    array    infections    hospitalized    symbionts    human    interactions    reveal    environmental    antigenically    immune    restore    mechanisms    first    activation    physiologic    experimental    inflammatory    cd8    immunity    generation    spf    vaccination    types    compartments    function    tissues    alter    trms    exposure    representing    memory    pools    contexts    explore    homeostasis    bacteria    free    canonical    immunotherapy    bdquo    patients    disease    abundance    infection    clinical    physiology    orchestrate    microbial    repair    vascular    alterations    laboratory    effector   

Project "TissueLymphoContexts" data sheet

The following table provides information about the project.

Coordinator
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG 

Organization address
address: SANDERRING 2
city: WUERZBURG
postcode: 97070
website: http://www.uni-wuerzburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙498˙750 €
 EC max contribution 1˙498˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG DE (WUERZBURG) coordinator 1˙498˙750.00

Map

 Project objective

Most anatomical compartments, including mucosal barrier surfaces, solid organs and vascular spaces host different types of tissue-resident lymphocytes providing local networks for immune surveillance and front-line defense to microbial invasion. In addition to immediate effector functions, tissue-resident lymphocytes orchestrate and regulate inflammatory responses, and contribute to tissue homeostasis, repair and barrier function. Understanding the generation and function of tissue-resident lymphocytes is therefore expected to reveal targets for improving vaccination and immunotherapy. Barrier tissues of free-living mice and men, but not those of laboratory mice kept under specific pathogen free conditions, are continuously exposed to an array of antigenically complex pathogens, microbial symbionts and environmental factors, which dramatically alter the abundance, composition and basal activation state of local pools of tissue-resident cells. Therefore, we propose to study the development, functions and cellular interactions of tissue-resident lymphocytes in experimental models that mirror “real-life” contexts. First, we will investigate how polyclonal pools of tissue-resident memory CD8 T cells (TRMs) are established during infection with antigenically complex pathogens. Second, we will restore physiologic exposure to specific pathogens and induce alterations of local microbiota in SPF mice, in order to investigate the induction, function and local interactions of tissue-resident lymphocytes in physiologic tissue environments. In addition, we will explore targeted microbial exposure as a „vaccination“ strategy to induce „non-canonical“ tissue-resident cells in the lung in order to improve protection against infections with multi-resistant bacteria representing major clinical problems in hospitalized patients. In summary, we will investigate fundamental mechanisms of tissue immunity and vaccination in contexts relevant for human physiology and disease.

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The information about "TISSUELYMPHOCONTEXTS" are provided by the European Opendata Portal: CORDIS opendata.

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