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TissueLymphoContexts SIGNED

Tissue-resident Lymphocytes: Development and Function in “real-life” Contexts

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 TissueLymphoContexts project word cloud

Explore the words cloud of the TissueLymphoContexts project. It provides you a very rough idea of what is the project "TissueLymphoContexts" about.

mirror    homeostasis    interactions    lung    cellular    kept    induction    trms    surveillance    exposed    composition    first    physiology    infection    resistant    tissues    laboratory    models    men    functions    array    solid    hospitalized    dramatically    mucosal    environments    memory    patients    exposure    cells    infections    mice    polyclonal    mechanisms    vaccination    fundamental    function    immunotherapy    compartments    symbionts    experimental    anatomical    reveal    barrier    microbiota    explore    inflammatory    clinical    regulate    lymphocytes    summary    local    disease    strategy    organs    generation    defense    antigenically    environmental    line    types    pathogens    alter    free    host    contexts    resident    physiologic    networks    cd8    front    human    effector    pools    spaces    bdquo    alterations    representing    surfaces    immune    restore    spf    living    repair    bacteria    pathogen    protection    life    canonical    most    orchestrate    basal    activation    invasion    vascular    abundance    tissue    induce    immunity    microbial   

Project "TissueLymphoContexts" data sheet

The following table provides information about the project.

Coordinator
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG 

Organization address
address: SANDERRING 2
city: WUERZBURG
postcode: 97070
website: http://www.uni-wuerzburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙498˙750 €
 EC max contribution 1˙498˙750 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG DE (WUERZBURG) coordinator 1˙498˙750.00

Map

 Project objective

Most anatomical compartments, including mucosal barrier surfaces, solid organs and vascular spaces host different types of tissue-resident lymphocytes providing local networks for immune surveillance and front-line defense to microbial invasion. In addition to immediate effector functions, tissue-resident lymphocytes orchestrate and regulate inflammatory responses, and contribute to tissue homeostasis, repair and barrier function. Understanding the generation and function of tissue-resident lymphocytes is therefore expected to reveal targets for improving vaccination and immunotherapy. Barrier tissues of free-living mice and men, but not those of laboratory mice kept under specific pathogen free conditions, are continuously exposed to an array of antigenically complex pathogens, microbial symbionts and environmental factors, which dramatically alter the abundance, composition and basal activation state of local pools of tissue-resident cells. Therefore, we propose to study the development, functions and cellular interactions of tissue-resident lymphocytes in experimental models that mirror “real-life” contexts. First, we will investigate how polyclonal pools of tissue-resident memory CD8 T cells (TRMs) are established during infection with antigenically complex pathogens. Second, we will restore physiologic exposure to specific pathogens and induce alterations of local microbiota in SPF mice, in order to investigate the induction, function and local interactions of tissue-resident lymphocytes in physiologic tissue environments. In addition, we will explore targeted microbial exposure as a „vaccination“ strategy to induce „non-canonical“ tissue-resident cells in the lung in order to improve protection against infections with multi-resistant bacteria representing major clinical problems in hospitalized patients. In summary, we will investigate fundamental mechanisms of tissue immunity and vaccination in contexts relevant for human physiology and disease.

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The information about "TISSUELYMPHOCONTEXTS" are provided by the European Opendata Portal: CORDIS opendata.

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