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DeCode SIGNED

Dendrites and memory: role of dendritic spikes in information coding by hippocampal CA3 pyramidal neurons

Total Cost €

EC-Contrib. €

Partnership

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DeCode project word cloud

Explore the words cloud of the DeCode project. It provides you a very rough idea of what is the project "DeCode" about.

individual ensembles mechanisms slices external ion dendrites induce cells spatiotemporally events patch understand underlie models hippocampal memory locations dentate code cortex spikes dependent cellular associative ca3 clamp functions hippocampus coding components behaving generate photon imaging vivo ca3pc neuronal electrophysiology context connections patterns active modulated integration rodents vitro recurrent generation inputs combining local hypothesis thought memories neurons voltage suggests gyrus microscopy channels ca3pcs plays entorhinal little plasticity ensemble amplification recruitment dendritic nonlinear receiving episodic elicit action contexts synaptic building poorly spatial area 2p network input correlated pyramidal mainly regulation pcs labelling

Project "DeCode" data sheet

The following table provides information about the project.

Coordinator	INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES Organization address address: Szigony utca 43 city: Budapest postcode: 1083 website: www.koki.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Hungary [HU]
Total cost	1˙990˙314 €
EC max contribution	1˙990˙314 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-COG
Funding Scheme	ERC-COG
Starting year	2018
Duration (year-month-day)	from 2018-06-01 to 2023-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES INSTITUTE OF EXPERIMENTAL MEDICINE - HUNGARIAN ACADEMY OF SCIENCES Organization address address: Szigony utca 43 city: Budapest postcode: 1083 website: www.koki.hu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (Budapest)	coordinator	1˙990˙314.00

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Project objective

The hippocampus is essential for building episodic memories. Coding of locations, contexts or events in the hippocampus is based on the correlated activity of neuronal ensembles; however, the mechanisms promoting the recruitment of individual neurons into information-coding ensembles are poorly understood. In particular, the recurrent synaptic network of pyramidal cells (PCs) in the hippocampal CA3 area, receiving external inputs from the entorhinal cortex and the dentate gyrus, is thought to be essential for associative memory. Current models of the associative functions of CA3 are mainly based on plasticity of these synaptic connections. Recent work by us and others however suggests that active, voltage-dependent properties of CA3PC dendrites may also promote ensemble functions. Dendritic voltage-dependent ion channels allow nonlinear amplification of spatiotemporally correlated synaptic inputs (such as those produced by ensemble activity) and can even generate local dendritic spikes, which may elicit specific action potential patterns and induce synaptic plasticity. Furthermore, dendritic processing may be modulated by activity-dependent regulation of dendritic ion channels. However, still little is known about the active properties of CA3PC dendrites and their functions during spatial coding or memory tasks. The general aim of my research program is to understand the cellular mechanisms that underlie the formation of hippocampal memory-coding neuronal ensembles. Specifically, we will test the hypothesis that active input integration by dendrites of individual CA3PCs plays an important role in their recruitment into specific context-coding ensembles. By combining in vitro (patch-clamp electrophysiology and two-photon (2P) microscopy in slices) and in vivo (2P imaging and activity-dependent labelling in behaving rodents) approaches, we will provide an in-depth understanding of the dendritic components contributing to the generation of the CA3 ensemble code.

Publications

List of publications.
year	authors and title	journal	last update
2019	Snezana Raus Balind, ÃdÃ¡m MagÃ³, Mahboobeh Ahmadi, NoÃ©mi Kis, ZsÃ³fia Varga-NÃ©meth, Andrea LÅ‘rincz, Judit K. Makara Diverse synaptic and dendritic mechanisms of complex spike burst generation in hippocampal CA3 pyramidal cells published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09767-w	Nature Communications 10/1	2020-02-05
2018	BalÃ¡zs B. Ujfalussy, Judit K. Makara, MÃ¡tÃ© Lengyel, Tiago Branco Global and Multiplexed Dendritic Computations under InÂ Vivo-like Conditions published pages: 579-592.e5, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2018.08.032	Neuron 100/3	2020-02-05

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