DYNAFLUORS SIGNED
Dynamic Activatable Fluorophores
Total Cost €
0EC-Contrib. €
0Partnership
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0DYNAFLUORS project word cloud
Explore the words cloud of the DYNAFLUORS project. It provides you a very rough idea of what is the project "DYNAFLUORS" about.
Project "DYNAFLUORS" data sheet
The following table provides information about the project.
| Coordinator |
THE UNIVERSITY OF EDINBURGH
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 1˙986˙650 € |
| EC max contribution | 1˙986˙650 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-06-01 to 2023-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | THE UNIVERSITY OF EDINBURGH | UK (EDINBURGH) | coordinator | 1˙986˙650.00 |
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Project objective
In DYNAFLUORS I will develop the first chemical toolbox for imaging in real time the activity of immune cells in tumours. Although the management of cancer has improved over the years, the cure rates for patients with metastasis and advanced tumours remain low due to lack of appropriate therapies. Recent studies suggest that drugs empowering host immune cells (i.e. immunotherapies) are promising approaches for intractable tumours. However, there are no tools to visualise and understand how host immune cells stop cancer progression in vivo. This important unmet challenge drives the ambitious targets of this proposal.
Over the past 10 years, I have pioneered the development of chemical fluorophores that allow unparalleled analysis of biological systems. In this project, I will implement an innovative approach to unify cutting-edge methodologies in chemistry and biology and develop Dynamic Activatable Fluorophores (DYNAFLUORS) as a chemical toolbox with enhanced imaging capabilities over current technologies.
The cross-disciplinary and ambitious nature of this project will open multiple avenues for broad impact in many areas of chemistry as well as in basic biology, imaging and medicine. DYNAFLUORS will allow us to image, from the molecular level to human tissue, the activity of immune cells in tumours and the response to therapy in real time. This ground-breaking chemical platform will represent a step forward in the forefront of chemical imaging and will create new opportunities in the personalised management of cancer.
In the long term, DYNAFLUORS will become a transformative toolbox for monitoring disease in humans. The integration of functional fluorophores into imaging technologies to perform ‘optical biopsies’ in vivo and to create patient-specific drug-response assays has the potential to revolutionise the diagnosis, stratification and personalised treatment of disease.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Matteo Virelli, Wei Wang, Rositha Kuniyil, Jun Wu, Giuseppe Zanoni, Antonio Fernandez, Jamie Scott, Marc Vendrell, Lutz Ackermann BODIPYâ€Labeled Cyclobutanes by Secondary C(sp 3 )−H Arylations for Liveâ€Cell Imaging published pages: 12712-12718, ISSN: 0947-6539, DOI: 10.1002/chem.201903461 |
Chemistry – A European Journal 25/55 | 2020-03-05 |
| 2019 |
Zhiming Cheng, Wagner O. Valença, Gleiston G. Dias, Jamie Scott, Nicole D. Barth, Fabio de Moliner, Gabriela B.P. Souza, Richard J. Mellanby, Marc Vendrell, Eufrânio N. da Silva Júnior Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues published pages: 3938-3946, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2019.07.017 |
Bioorganic & Medicinal Chemistry 27/17 | 2020-03-05 |
| 2019 |
Evita Ning, Gareth Turnbull, Jon Clarke, Fred Picard, Philip Riches, Marc Vendrell, Duncan Graham, Alastair W Wark, Karen Faulds, Wenmiao Shu 3D bioprinting of mature bacterial biofilms for antimicrobial resistance drug testing published pages: 45018, ISSN: 1758-5090, DOI: 10.1088/1758-5090/ab37a0 |
Biofabrication 11/4 | 2020-03-05 |
| 2019 |
Can Zhao, Lorena Mendive-Tapia, Marc Vendrell Fluorescent peptides for imaging of fungal cells published pages: 187-195, ISSN: 0003-9861, DOI: 10.1016/j.abb.2018.11.018 |
Archives of Biochemistry and Biophysics 661 | 2020-02-28 |
| 2018 |
Fabio de Moliner, Aaron King, Gleiston G. Dias, Guilherme F. de Lima, Carlos A. de Simone, Eufrânio N. da Silva Júnior, Marc Vendrell Quinone-Derived π-Extended Phenazines as New Fluorogenic Probes for Live-Cell Imaging of Lipid Droplets published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2018.00339 |
Frontiers in Chemistry 6 | 2020-02-28 |
| 2019 |
Antonio Fernandez, Emily J. Thompson, Jeffrey W. Pollard, Takanori Kitamura, Marc Vendrell A Fluorescent Activatable AND-Gate Chemokine CCL2 Enables In Vivo Detection of Metastasis-Associated Macrophages published pages: 16894-16898, ISSN: 1433-7851, DOI: 10.1002/anie.201910955 |
Angewandte Chemie International Edition 58/47 | 2020-02-28 |
| 2019 |
Zhigao Yi, Zichao Luo, Nicole D. Barth, Xianfu Meng, Hong Liu, Wenbo Bu, Angelo All, Marc Vendrell, Xiaogang Liu In Vivo Tumor Visualization through MRI Offâ€On Switching of NaGdF 4 –CaCO 3 Nanoconjugates published pages: 1901851, ISSN: 0935-9648, DOI: 10.1002/adma.201901851 |
Advanced Materials 31/37 | 2020-02-28 |
| 2019 |
Marc Vendrell, Antonio Fernandez, Richard Mellanby, Jamie Scott, Iris Mair, Claudia Garcia-Guzman, Baljean Dhillon, Pierre Bagnaninchi Near-infrared chromophores, process of preparation and methods of use published pages: , ISSN: , DOI: |
2020-02-28 | |
| 2019 |
Sam Benson, Antonio Fernandez, Nicole D. Barth, Fabio de Moliner, Mathew H. Horrocks, C. Simon Herrington, Jose Luis Abad, Antonio Delgado, Lisa Kelly, Ziyuan Chang, Yi Feng, Miyako Nishiura, Yuichiro Hori, Kazuya Kikuchi, Marc Vendrell SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism published pages: 6911-6915, ISSN: 1433-7851, DOI: 10.1002/anie.201900465 |
Angewandte Chemie International Edition 58/21 | 2020-02-28 |
| 2018 |
Richard J. Mellanby, Jamie I. Scott, Iris Mair, Antonio Fernandez, Louise Saul, Jochen Arlt, Monica Moral, Marc Vendrell Tricarbocyanine N -triazoles: the scaffold-of-choice for long-term near-infrared imaging of immune cells in vivo published pages: 7261-7270, ISSN: 2041-6520, DOI: 10.1039/c8sc00900g |
Chemical Science 9/36 | 2020-02-28 |
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