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DYCOCIRC SIGNED

Basal ganglia circuit mechanisms underlying dynamic cognitive behavior

Total Cost €

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EC-Contrib. €

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Partnership

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 DYCOCIRC project word cloud

Explore the words cloud of the DYCOCIRC project. It provides you a very rough idea of what is the project "DYCOCIRC" about.

bases    judgments    promise    bg    understand    da    image    decision    dynamic    faced    either    moment    reward    implicated    types    time    function    stages    mice    actions    relate    neuron    relationship    multiple    choices    rats    explicitly    animals    learning    basal    nature    toward    inputs    neural    signals    uniquely    computational    exert    frontal    fruitful    choosing    cortico    immediacy    safer    planning    onto    demonstrated    regarding    weigh    judge    neurons    transformed    do    cell    circuit    population    elapsed    dopamine    difficult    dynamics    dissect    kinds    broadly    themselves    mechanisms    mapping    brain    re    recording    satisfying    representation    striatal    mysteries    cognition    manipulate    people    poised    existence    ganglia    events    critical    input    previously    experiments    laboratory    free    generate    populations    neuromodulatory    internal    circuits    journey    unlock    behavior    implicitly    deep    dopaminergic    correlate   

Project "DYCOCIRC" data sheet

The following table provides information about the project.

Coordinator
FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD 

Organization address
address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD
city: LISBOA
postcode: 1400-038
website: http://fchampalimaud.org/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Portugal [PT]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD PT (LISBOA) coordinator 2˙000˙000.00

Map

 Project objective

You’re faced with a difficult choice. What do you do? Most people will, either explicitly or implicitly, weigh the possible consequences their decision. This involves an internal journey through possible events. Its these kinds of dynamic processes and their mapping onto behavior that characterize higher brain function. And yet, their very internal nature is both what makes them of critical interest and so difficult to study. Here, we propose to study a simple, well-controlled decision-making behavior wherein mice have to generate a dynamic, internal representation of elapsed time in order to make choices that result in reward. We focus on frontal cortico-basal ganglia circuits and their dopaminergic inputs that together are broadly implicated in cognition and involved in the production of this particular behavior. We have demonstrated previously that striatal population dynamics and dopamine neuron activity both correlate with and exert control over animals’ judgments. Having identified key signals at multiple stages of the BG circuit related to this decision in rats and mice, my laboratory is now uniquely poised to dissect the circuit mechanisms by which such signals are generated and transformed into actions. Specifically, we will 1) Measure activity of specific cell types at multiple stages of the BG as mice judge duration. 2) Image and manipulate the activity of DA neurons while recording from neural populations in the BG to determine the relationship between neuromodulatory input, neural dynamics, and behavior. 3) Relate the activity of cortico-striatal inputs to striatal responses during behavior to understand the computational and circuit bases of striatal activity. These experiments promise to unlock deep mysteries regarding how animals free themselves from the immediacy of the current moment, learning, planning, and choosing their path toward a safer, more fruitful, and satisfying existence.

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The information about "DYCOCIRC" are provided by the European Opendata Portal: CORDIS opendata.

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