Explore the words cloud of the PneumoCaTChER project. It provides you a very rough idea of what is the project "PneumoCaTChER" about.
The following table provides information about the project.
Coordinator |
UNIVERSITE DE LAUSANNE
Organization address contact info |
Coordinator Country | Switzerland [CH] |
Total cost | 1˙999˙735 € |
EC max contribution | 1˙999˙735 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2017-COG |
Funding Scheme | ERC-COG |
Starting year | 2018 |
Duration (year-month-day) | from 2018-11-01 to 2023-10-31 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | UNIVERSITE DE LAUSANNE | CH (LAUSANNE) | coordinator | 1˙999˙735.00 |
Within clonal bacterial populations not all cells exhibit the same phenotype, even though they grow in the same environment. The molecular sources contributing to phenotypic variation are diverse and can originate from noise in gene expression to heterogeneity in growth rates or cell cycle state. Phenotypic variation helps pathogenic bacteria to elude the host immune response or resist antibiotic pressure. Vice versa, there is cell-to-cell variability in the host’s response towards pathogens that can be exploited by bacteria. How the combined cellular heterogeneity of both host and microbe contribute to infection outcome is poorly understood. The role of phenotypic variation on antibiotic resistance development is also unclear.
Recently, we developed novel single cell imaging systems as well as genetic engineering and screening platforms for application to the important opportunistic human pathogen Streptococcus pneumoniae. In addition, we generated a dual-transcriptomics overview of pneumococcal infection of human lung epithelial cells and setup collaborations to perform several infection models. This now places us in an excellent position to investigate the mechanisms and the importance of single cell behaviour for pneumococcal virulence and antibiotic resistance.
The driving hypothesis of this application is that the combined heterogeneity of host cells and pneumococci influences infection and antibiotic therapy outcome. To test this, we will use innovative approaches for infection biology by combining synthetic biology and quantitative single cell biology including single cell RNA-seq, CRISPRi, engineered bistable switches and microfluidics. We will reveal the molecular mechanisms underlying cell-to-cell variability and its importance in virulence and antibiotic resistance.
Insights obtained in this project will lead to a better understanding of phenotypic variation and might result in new treatment strategies for pneumococcal infections.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Jelle Slager, Rieza Aprianto, Jan-Willem Veening Refining the Pneumococcal Competence Regulon by RNA Sequencing published pages: , ISSN: 0021-9193, DOI: 10.1128/jb.00780-18 |
Journal of Bacteriology 201/13 | 2019-08-29 |
2019 |
Lance E. Keller, Anne-Stéphanie Rueff, Jun Kurushima, Jan-Willem Veening Three New Integration Vectors and Fluorescent Proteins for Use in the Opportunistic Human Pathogen Streptococcus pneumoniae published pages: 394, ISSN: 2073-4425, DOI: 10.3390/genes10050394 |
Genes 10/5 | 2019-08-29 |
2019 |
Chryslène Mercy, Adrien Ducret, Jelle Slager, Jean-Pierre Lavergne, Céline Freton, Sathya Narayanan Nagarajan, Pierre Simon Garcia, Marie-Francoise Noirot-Gros, Nelly Dubarry, Julien Nourikyan, Jan-Willem Veening, Christophe Grangeasse RocS drives chromosome segregation and nucleoid protection in Streptococcus pneumoniae published pages: , ISSN: 2058-5276, DOI: 10.1038/s41564-019-0472-z |
Nature Microbiology | 2019-08-29 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PNEUMOCATCHER" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "PNEUMOCATCHER" are provided by the European Opendata Portal: CORDIS opendata.