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MINIRES

A Minimalist Peptide Elastomer

Total Cost €

EC-Contrib. €

Partnership

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MINIRES project word cloud

Explore the words cloud of the MINIRES project. It provides you a very rough idea of what is the project "MINIRES" about.

elastomeric surprising physical polymeric revolutionary technically sequence suitable perform trivial small industrial scalability 320 patent fact insects repeat found commercial possibility exon valorizing flight minires modifications protein setting foldhalo creation resembling halogenation starting scouting determines unmodified advantage foreseeing induces material grant acids length jumping simplicity critical deposited chains market bioelastomer linking structural minimalist opening feasibility maturity huge emergence intend either elasticity rubber supramolecular strategy res course erc move amino accelerate formulations cross family modification peptides start peptide vs pure natural resilin outcomes 307108 outstanding validating lies chemical lab licensing compound biomimetic full

Project "MINIRES" data sheet

The following table provides information about the project.

Coordinator	POLITECNICO DI MILANO Organization address address: PIAZZA LEONARDO DA VINCI 32 city: MILANO postcode: 20133 website: www.polimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-PoC
Funding Scheme	ERC-POC
Starting year	2018
Duration (year-month-day)	from 2018-04-01 to 2019-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	POLITECNICO DI MILANO POLITECNICO DI MILANO Organization address address: PIAZZA LEONARDO DA VINCI 32 city: MILANO postcode: 20133 website: www.polimi.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	coordinator	150˙000.00

Map

Project objective

The MINIRES project aims at developing and bringing to the market a revolutionary bioelastomer material based on a novel strategy of structural modification of a “minimalist” peptide sequence derived from Resilin (Res), i.e., a polymeric rubber-like natural protein with outstanding elasticity, critical in the flight and jumping systems of insects. In the course of the ERC funded Starting Grant FOLDHALO (grant agreement no. 307108), I focused on the modification of a repeat sequence of the Exon-1 (~320 amino acids) of Res. We found that a biomimetic chemical modification of this sequence (i.e., halogenation) induces the emergence of elastomeric properties resembling those of the full-length Res protein. This is surprising for such a short peptide, and the unmodified peptide, in fact, does not show such properties. Halogenation determines a huge change in the material properties due to the induced physical (supramolecular) cross-linking of the peptide chains. The main advantage of the novel “minimalist” bioelastomer that we developed lies in its chemical and structural simplicity. This simplicity allows foreseeing easy industrial scalability at low costs, trivial processing, either as pure compound or component of elastomeric formulations, as well as possibility of further chemical and structural modifications (opening up a family of small elastomeric peptides). Expected outcomes of the MINIRES project are to perform a technical and commercial feasibility study to move the developed “minimalist” bioelastomer from the lab to the market. In particular, within the MINIRES project, we intend to accelerate the maturity level of this technology, by technically validating it, as well as scouting market opportunities and setting up a suitable exploitation strategy (licensing vs. start-up creation) for valorizing the patent that has being deposited.

Publications

List of publications.
year	authors and title	journal	last update
2019	Kavitha Buntara Sanjeeva, Claudia Pigliacelli, Lara Gazzera, Valentina Dichiarante, Francesca Baldelli Bombelli, Pierangelo Metrangolo Halogen bond-assisted self-assembly of gold nanoparticles in solution and on a planar surface published pages: 18407-18415, ISSN: 2040-3364, DOI: 10.1039/c9nr07054k	Nanoscale 11/39	2020-02-18
2019	Claudia Pigliacelli, Kavitha Buntara Sanjeeva, Nonappa, Andrea Pizzi, Alessandro Gori, Francesca Baldelli Bombelli, Pierangelo Metrangolo In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination published pages: , ISSN: 1936-0851, DOI: 10.1021/acsnano.8b08805	ACS Nano	2020-02-18
2019	Alfonso Gautieri, Alberto Milani, Andrea Pizzi, Federica Rigoldi, Alberto Redaelli, Pierangelo Metrangolo Molecular dynamics investigation of halogenated amyloidogenic peptides published pages: , ISSN: 1610-2940, DOI: 10.1007/s00894-019-4012-9	Journal of Molecular Modeling 25/5	2020-02-18
2019	Andrea Pizzi, Haxel Lionel Ozores, MartÃn Calvelo, Rebeca GarcÃa-FandiÃ±o, Manuel AmorÃn, Nicola Demitri, Giancarlo Terraneo, Silvia Bracco, Angiolina Comotti, Piero Sozzani, Charl X. Bezuidenhout, Pierangelo Metrangolo, Juan R. Granja Tight Xenon Confinement in a Crystalline Sandwich-like Hydrogen-Bonded Dimeric Capsule of a Cyclic Peptide published pages: 14472-14476, ISSN: 1433-7851, DOI: 10.1002/anie.201906599	Angewandte Chemie International Edition 58/41	2020-02-18

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The information about "MINIRES" are provided by the European Opendata Portal: CORDIS opendata.