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ALPINE SIGNED

Ultrastructural analysis of phosphoinositides in nerve terminals: distribution, dynamics and physiological roles in synaptic transmission

Total Cost €

EC-Contrib. €

Partnership

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ALPINE project word cloud

Explore the words cloud of the ALPINE project. It provides you a very rough idea of what is the project "ALPINE" about.

synapses pattern electrophysiological pi poorly proteins regulate synaptic ranges functions mammalian presynaptic breakthrough optogenetics brain physiological transmission subcellular mechanisms cellular active pis techniques nano difficulties distributes understand fundamental membranes azs meter coupling peri unveil phosphoinositides localization biochemical roles cell functionally give protein couplings interact play co chemical zones microscopic dynamics ultrastructural components terminals nerve tools electron minor machinery domains cooperate interdisciplinary combined

Project "ALPINE" data sheet

The following table provides information about the project.

Coordinator	INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA Organization address address: Am Campus 1 city: KLOSTERNEUBURG postcode: 3400 website: www.ist.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Total cost	178˙156 €
EC max contribution	178˙156 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-04-01 to 2020-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA Organization address address: Am Campus 1 city: KLOSTERNEUBURG postcode: 3400 website: www.ist.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (KLOSTERNEUBURG)	coordinator	178˙156.00

Map

Project objective

Phosphoinositides (PIs) are minor components of cell membranes, and play important roles in cellular functions. In chemical synapses in mammalian brain, each PI distributes different subcellular areas in nerve terminals, and cooperate with many proteins to regulate synaptic transmission machinery. To understand how PIs regulate synaptic transmission, the ultrastructural distribution pattern and dynamics of PIs at nerve terminals are crucial because PIs may functionally interact with proteins at domains of nano-meter ranges called active zones (AZs) or peri-AZs. However, their ultrastructural distribution and dynamics in nerve terminals are poorly investigated because of some technical difficulties. This research project aims to investigate (1) the ultrastructural distribution of PIs at AZs and peri-AZs in nerve terminals, (2) co-localization of PIs with presynaptic proteins related to synaptic transmission, (3) the ultrastructural dynamics of PIs and PI-protein coupling during synaptic transmission, and (4) the physiological roles of PI-protein couplings in synaptic transmission, using electron microscopic and electrophysiological techniques combined with optogenetics and biochemical tools. These highly-interdisciplinary approaches will unveil the physiological roles of PIs and PI-protein couplings in synaptic transmission, and is expected to give a fundamental breakthrough in understanding mechanisms of synaptic transmission.

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The information about "ALPINE" are provided by the European Opendata Portal: CORDIS opendata.