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MECoCaM SIGNED

Human gut Microbiome, gene Expression and Colorectal Cancer: Assigning causal roles from a novel Mendelian randomization perspective.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MECoCaM project word cloud

Explore the words cloud of the MECoCaM project. It provides you a very rough idea of what is the project "MECoCaM" about.

therapeutic    germ    unravelling    tumour    biopsies    environmental    transcriptomic    stages    putative    cell    enrichment    integrating    variation    prevention    integrate    causality    mucosa    variables    intestinal    expression    cells    epithelial    proliferation    understand    assume    exposure    phenotyped    identification    correlations    epithelium    aetiology    colorectal    causal    pleiotropy    influenced    samples    genetic    microbial    carcinogenesis    normal    indicate    estimates    communities    whereby    proxies    mr    unconfounded    validated    description    absence    association    line    gut    interaction    relevance    assuming    mendelian    proxied    layer    reverse    500    randomization    colon    gene    instrumental    mediators    causation    microbe    host    outcome    microbes    data    interactions    ecosystem    strategies    analytical    markers    crc    inflammatory    risk    exposures    contribution    manner    mechanistic    microbiome    site    assign    omic    functional    confounding    additionally    sequencing    unbalance    cancer   

Project "MECoCaM" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE 

Organization address
address: AVENIDA GRAN VIA HOSPITALET 199-203
city: L'HOSPITALET DE LLOBREGAT
postcode: 8908
website: www.idibell.cat

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-03   to  2020-09-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE ES (L'HOSPITALET DE LLOBREGAT) coordinator 158˙121.00

Map

 Project objective

The contribution of the gut microbial ecosystem to colorectal cancer (CRC) is not well understood. Inflammatory processes and unbalance cell proliferation in the host could be behind observed correlations between a microbe and cancer stages. However, the enrichment of a microbe at a tumour site does not directly assume causation. Rather, this could be the result of a reverse causation or a confounding third factor. Therefore, two major challenges unravelling CRC aetiology are (i) to identify the mechanistic interactions of microbial communities with host intestinal epithelium cells, and (ii) to assign causality to carcinogenesis. These are the aims of this project integrating different “omic” data, and using a Mendelian randomization (MR) approach. In this study we analyse microbiome sequencing data, from up to 500 normal colon mucosa biopsies, to provide a comprehensive description of the gut microbiome. Additionally, we integrate transcriptomic data from these well phenotyped 500 samples to understand the interaction between microbes and the gut epithelial cells. Finally, using the germ-line genetic variation of host cells as a third “omic” layer, the correlations between microbes and (i) environmental exposures, (ii) gene expression, and (iii) CRC can be validated by MR. MR is an analytical approach whereby germ-line genetic markers are used as proxies – or instrumental variables – for putative risk factors. These genetic markers cannot be influenced by reverse causation, and, assuming an absence of pleiotropy, can provide unconfounded estimates of association. Therefore, a MR association between genetic proxies and the outcome of interest would indicate that the exposure being proxied is associated in a causal manner. The identification of the functional relevance and key mediators of gut microbiome to colorectal cancer development is going to increase the development of therapeutic approaches and prevention strategies.

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The information about "MECOCAM" are provided by the European Opendata Portal: CORDIS opendata.

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