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PPOM-PTT SIGNED

New Peptide-Polyoxometalate Hybrids for Antimicrobial Photothermal Therapy

Total Cost €

EC-Contrib. €

Partnership

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PPOM-PTT project word cloud

Explore the words cloud of the PPOM-PTT project. It provides you a very rough idea of what is the project "PPOM-PTT" about.

potentials establishing experiments construct material anticancer believe vital expertise create ptt inspired polyoxometalates plan progress global poms direction evaluation appropriate conclude impacts 25 standard ms linkage tackle ampicillin besides resistant reasonable chemistry poly covalent enormous repeating exert biological peptides bilateral epsilon capacities route kinds lysines attracting units she assembly beneficiary people 15 basically synthesis community attentions orientation resistance class chemical health antibacterial ppoms researches cronin interdisciplinary hybrids noncovalent photothermal pom exploring life series divided antimicrobial characterization threatening group host endowing scientific country interferences coli boundary therapy self influence region

Project "PPOM-PTT" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2018
Duration (year-month-day)	from 2018-09-01 to 2020-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY OF GLASGOW UNIVERSITY OF GLASGOW Organization address address: UNIVERSITY AVENUE city: GLASGOW postcode: G12 8QQ website: www.gla.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (GLASGOW)	coordinator	195˙454.00

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Project objective

Antimicrobial resistance is a global challenge which is threatening the life and health of people from every country and region. Basically, most of the chemical or biological interferences may cause resistance to some extent. Recently, photothermal therapy (PTT) is attracting increasing attentions in anticancer researches and bringing enormous impacts in our scientific community. Inspired by this progress, we plan to construct a new class of peptides-polyoxometalates (PPOMs) hybrids for antimicrobial photothermal therapy. We do believe that this project will create a new research orientation in the interdisciplinary boundary between POM chemistry, photothermal therapy and antimicrobial therapy. To this end, we propose a reasonable route divided into three steps: (i) developing a series of PPOMs by covalent or noncovalent linkage of three kinds of POMs and epsilon-poly-L-lysines with 10, 15, 20, 25, 30 repeating units; (ii) endowing PPOMs with photothermal capacities by chemical reduction and establishing a standard method for photothermal antimicrobial experiments based on PPOMs; (iii) evaluating their photothermal antimicrobial activity against non-resistant and ampicillin-resistant E. coli and exploring their potentials to tackle the antimicrobial resistance. This proposal is appropriate for both beneficiary and host. Ms. She has experience in POM synthesis, anticancer therapy and self-assembly, which will be vital in this research. Besides, the expertise in Cronin’s group involving POMs, peptides synthesis, antibacterial evaluation and material characterization will be crucial for this proposal. More importantly, this project will become one step further in the research direction of Cronin's group. To conclude, this project will exert a strong influence in the field of POM chemistry and antimicrobial research, and the bilateral success between host and beneficiary will be achieved.

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