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OSCILLOGEL SIGNED

An enzyme-based self-oscillating gel

Total Cost €

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EC-Contrib. €

0

Partnership

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 OSCILLOGEL project word cloud

Explore the words cloud of the OSCILLOGEL project. It provides you a very rough idea of what is the project "OSCILLOGEL" about.

unreacted    inorganic    lacking    continual    engineer    biological    drive    wish    source    collective    lifts    differentiation    enzyme    property    biologically    exploring    inconvenience    stress    intrinsic    elasticity    mostly    mechano    flow    reactions    regulatory    versa    diffusion    emerges    transport    morphogenesis    autonomous    chemistry    valve    motion    big    motility    synthetic    underlying    lowers    shrinks    attributed    force    opening    mechanics    release    popular    subsystems    continuous    vice    living    models    environment    loops    periodic    generally    arise    understand    biocompatible    load    insufficiently    maintained    reactants    biochemistry    oscillator    uniform    external    power    though    constant    swells    urea    mechanical    energy    closing    forwards    off    fresh    structural    obtain    counterintuitive    fit    feedback    responsive    oscillatory    merely    reaction    immobilized    linked    periodicity    self    chemoresponsive    biochemical    individually    clue    functions    pull    interdependence    oscillation    dynamic    hydrogel    components    lacks    eliminated    gel    found    coupled    rigid    urease    itself    operated    material    chemical    first    stimuli    corresponding   

Project "OSCILLOGEL" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF SHEFFIELD 

Organization address
address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN
website: www.shef.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 183˙454.00

Map

 Project objective

Self-oscillation is a periodic motion generated and maintained by a source of power that lacks the corresponding periodicity. In living systems several periodic motility processes or structural differentiation arise with no on-off stimuli, merely under the continual flow-in and flow-out of material and energy. The popular synthetic dynamic models use oscillatory chemical reactions to drive the system, though in most real cases no underlying biochemical oscillator is found. One clue is in the interdependence of chemistry and mechanics (stress, elasticity, or transport). Periodicity is counterintuitive because it cannot be attributed to any of the subsystems individually: this property emerges only through the collective behaviour of the components, as a systems-level property. To understand biological systems, we need to understand how these properties and functions are generated and controlled. Feedback-loops between chemical and mechanical processes are intrinsic in morphogenesis, though mechano-chemical feedback is generally still lacking in synthetic systems. I build coupled reaction-diffusion-mechanics systems, where a chemoresponsive hydrogel swells and shrinks (and, e.g., lifts and lowers a load) in a constant and uniform unreacted chemical environment, with no external stimuli. The chemistry is not oscillatory in itself, that is, if the gel is rigid or insufficiently responsive. Previous systems (mostly with inorganic reactions) operated under the continuous flow of fresh reactants. This inconvenience would be eliminated by making a big step forwards to biochemistry, where the reaction is linked to an enzyme immobilized in the gel. First we wish to demonstrate such a biocompatible system with the urease-urea reaction. After exploring the operating conditions, this autonomous system could fit to engineer regulatory functions by opening-closing a valve or to obtain biologically meaningful chemical responses by applying a force (pull, release) and vice versa.

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