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OSCILLOGEL SIGNED

An enzyme-based self-oscillating gel

Total Cost €

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EC-Contrib. €

0

Partnership

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 OSCILLOGEL project word cloud

Explore the words cloud of the OSCILLOGEL project. It provides you a very rough idea of what is the project "OSCILLOGEL" about.

mechanical    biochemistry    emerges    swells    mechano    operated    elasticity    individually    drive    biochemical    periodic    rigid    regulatory    differentiation    biocompatible    intrinsic    fresh    feedback    engineer    oscillatory    components    mostly    continuous    immobilized    uniform    loops    big    chemistry    synthetic    interdependence    found    versa    exploring    motion    oscillator    release    force    collective    unreacted    reactions    valve    forwards    morphogenesis    transport    motility    shrinks    fit    self    linked    load    corresponding    stimuli    energy    lifts    biological    vice    opening    stress    oscillation    eliminated    arise    popular    external    lacking    subsystems    wish    mechanics    clue    obtain    gel    itself    attributed    enzyme    environment    constant    though    power    coupled    periodicity    inorganic    off    urease    lowers    reaction    counterintuitive    urea    merely    reactants    continual    models    responsive    chemical    lacks    chemoresponsive    hydrogel    underlying    biologically    generally    material    closing    autonomous    flow    diffusion    insufficiently    inconvenience    understand    structural    dynamic    living    pull    maintained    source    property    first    functions   

Project "OSCILLOGEL" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF SHEFFIELD 

Organization address
address: FIRTH COURT WESTERN BANK
city: SHEFFIELD
postcode: S10 2TN
website: www.shef.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-CAR
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2021-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SHEFFIELD UK (SHEFFIELD) coordinator 183˙454.00

Map

 Project objective

Self-oscillation is a periodic motion generated and maintained by a source of power that lacks the corresponding periodicity. In living systems several periodic motility processes or structural differentiation arise with no on-off stimuli, merely under the continual flow-in and flow-out of material and energy. The popular synthetic dynamic models use oscillatory chemical reactions to drive the system, though in most real cases no underlying biochemical oscillator is found. One clue is in the interdependence of chemistry and mechanics (stress, elasticity, or transport). Periodicity is counterintuitive because it cannot be attributed to any of the subsystems individually: this property emerges only through the collective behaviour of the components, as a systems-level property. To understand biological systems, we need to understand how these properties and functions are generated and controlled. Feedback-loops between chemical and mechanical processes are intrinsic in morphogenesis, though mechano-chemical feedback is generally still lacking in synthetic systems. I build coupled reaction-diffusion-mechanics systems, where a chemoresponsive hydrogel swells and shrinks (and, e.g., lifts and lowers a load) in a constant and uniform unreacted chemical environment, with no external stimuli. The chemistry is not oscillatory in itself, that is, if the gel is rigid or insufficiently responsive. Previous systems (mostly with inorganic reactions) operated under the continuous flow of fresh reactants. This inconvenience would be eliminated by making a big step forwards to biochemistry, where the reaction is linked to an enzyme immobilized in the gel. First we wish to demonstrate such a biocompatible system with the urease-urea reaction. After exploring the operating conditions, this autonomous system could fit to engineer regulatory functions by opening-closing a valve or to obtain biologically meaningful chemical responses by applying a force (pull, release) and vice versa.

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The information about "OSCILLOGEL" are provided by the European Opendata Portal: CORDIS opendata.

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