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PROCHIP SIGNED

Chromatin organization PROfiling with high-throughput super-resolution microscopy on a CHIP

Total Cost €

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EC-Contrib. €

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Partnership

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 PROCHIP project word cloud

Explore the words cloud of the PROCHIP project. It provides you a very rough idea of what is the project "PROCHIP" about.

diagnosis    fluorescence    cell    microfluidic    young    influenced    glass    movement    chip    toxicity    channels    fabricating    microfluidics    types    brand    substrate    organization    heterogeneity    benchmarks    pathogenic    thousands    functional    domains    epigenetics    microscope    illumination    device    therapeutic    biological    scanned    resistance    tumor    analyze    profile    sciences    precision    computer    waveguides    company    femtosecond    fluidic    function    genetic    differential    samples    decipher    predicting    epigenetic    outcome    smaller    minimal    integrate    microchannels    resolution    data    super    frontier    microenvironment    photonics    driving    imaging    tumorigenesis    hundreds    scientists    none    responsiveness    progression    throughput    diffraction    guidance    chromatin    permit    coin    formed    limit    causing    3d    opening    accurate    single    possibilities    cells    excitation    therapies    optofluidic    lenses    components    force    technologies    heterogeneities    disease    photo    fashion    cancer    universities    micromachining    automatic    laser    medical   

Project "PROCHIP" data sheet

The following table provides information about the project.

Coordinator
CONSIGLIO NAZIONALE DELLE RICERCHE 

Organization address
address: PIAZZALE ALDO MORO 7
city: ROMA
postcode: 185
website: www.cnr.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website https://pro-chip.eu/
 Total cost 2˙496˙525 €
 EC max contribution 2˙496˙525 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) coordinator 601˙250.00
2    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 511˙880.00
3    ELVESYS FR (PARIS) participant 499˙271.00
4    UNIVERSITA DEGLI STUDI DI TRENTO IT (TRENTO) participant 492˙873.00
5    INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON FR (VILLEURBANNE CEDEX) participant 360˙250.00
6    UNIVERSITE D'ANGERS FR (ANGERS CEDEX 01) participant 31˙000.00

Map

 Project objective

Cancer is both a genetic and an epigenetic disease whose outcome is influenced by tumor microenvironment, which represents the major driving force of tumorigenesis causing the functional heterogeneity observed in most cancer types. Defining the 3D-organization of cancer-associated chromatin domains would represent a new frontier to decipher tumor heterogeneity. None of the currently available technologies permit to rapidly analyze thousands of cells and profile their chromatin organization at single cell level, as needed for medical diagnosis and therapeutic guidance. The goal of the project is to build a high-throughput super-resolution microscope in a microfluidic chip smaller than a coin. With this device we will provide high resolution imaging of hundreds of cells at the diffraction limit and beyond, with minimal photo-toxicity. Femtosecond laser micromachining allows fabricating with accurate precision optofluidic components as waveguides, microchannels and lenses in a glass substrate. We will integrate them in a single chip, to achieve the required illumination path for advanced fluorescence excitation and sample movement: in the same chip biological samples will be scanned along fluidic channels in a fully automatic fashion. High-throughput data on chromatin distribution in hundreds of samples will be generated, allowing to decipher the pathogenic function of tumor heterogeneities in tumor progression. These data will be used as benchmarks for predicting differential responsiveness and/or resistance of cancer cells to targeted therapies opening brand new possibilities for medical diagnosis and therapeutic guidance. The consortium is formed by young scientists from Universities in the field of photonics, computer sciences and epigenetics, and a leading company in microfluidics.

 Publications

year authors and title journal last update
List of publications.
2019 Andrea Crespi, Roberto Osellame, Francesca Bragheri
Femtosecond-laser-written optofluidics in alumino-borosilicate glass
published pages: 100042, ISSN: 2590-1478, DOI: 10.1016/j.omx.2019.100042
Optical Materials: X 4 2020-02-06
2019 Authors Ali Ahmad, Carole Frindel, David Rousseau
Détection de différence de densité de marqueurs fluorescents en microscopie superrésolue : approche pointilliste ou texturale ?
published pages: , ISSN: , DOI:
2019-12-16
2019 Ali Ahmad, Carole Frindel, Pejman Rasti, David Sarrut, David Rousseau
Deep learning based detection of cells in 3D light sheet fluorescence microscopy
published pages: , ISSN: , DOI:
Quantitative BioImaging Conference 2019-12-16
2019 Federico Sala, Petra Paiè, Roberto Memeo, Roberto Osellame, Andrea Farina, Andrea Bassi, Francesca Bragheri
Optofluidic lab-on-chips for high throughput 3D imaging of cells and tissues
published pages: 11002, ISSN: 2100-014X, DOI: 10.1051/epjconf/201921511002
EPJ Web of Conferences 215 2019-11-20

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The information about "PROCHIP" are provided by the European Opendata Portal: CORDIS opendata.

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