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EVO-NANO SIGNED

Evolvable platform for programmable nanoparticle-based cancer therapies

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EVO-NANO project word cloud

Explore the words cloud of the EVO-NANO project. It provides you a very rough idea of what is the project "EVO-NANO" about.

evo interactions physicell anti give scenarios forefront tumours cross predictive desired realistic nano stem interacting drug innovative cancer days autonomously faster colon create stage investors organize surfaces breast disciplinary testbeds industrial space platform search algorithms strategy variety nanoparticles tumour accuracy generate vitro adapt microenvironments tested industry nanodoc mouse mathcancer simulators nanomedicines collective biodistribution nanoparticle xenografts tools diagnosis motion featuring vivo evolution reproduces treatments org solutions artificial nanomedicine outcome environment synthesized designs limitation adaptive cells patients entirely evolutionary commercialized discover clinical strategies http np simultaneously translation multidisciplinary prochimia trillions microfluidic class

Project "EVO-NANO" data sheet

The following table provides information about the project.

Coordinator	Univerzitet u Novom Sadu, Poljoprivredni fakultet Novi Sad Organization address address: TRG DOSITEJA OBRADOVICA 8 city: NOVI SAD postcode: 21000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Serbia [RS]
Project website	http://evonano.eu
Total cost	2˙988˙658 €
EC max contribution	2˙988˙658 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-10-01 to 2021-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	Univerzitet u Novom Sadu, Poljoprivredni fakultet Novi Sad Univerzitet u Novom Sadu, Poljoprivredni fakultet Novi Sad Organization address address: TRG DOSITEJA OBRADOVICA 8 city: NOVI SAD postcode: 21000 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	RS (NOVI SAD)	coordinator	284˙843.00
2	FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA Organization address address: PASSEIG VALL D HEBRON 119-129 EDIFICIO DE RECERCA city: BARCELONA postcode: 8035 website: http://www.vhir.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	568˙847.00
3	PROCHIMIA SURFACES SP. Z O.O. PROCHIMIA SURFACES SP. Z O.O. Organization address address: ZACISZE 2 city: SOPOT postcode: 81823 website: www.prochimia.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PL (SOPOT)	participant	514˙375.00
4	FUNDACION IMDEA NANOCIENCIA FUNDACION IMDEA NANOCIENCIA Organization address address: CIUDAD UNIVERSITARIA DE CANTOBLANCO - CALLE FARADAY 9 city: MADRID postcode: 28049 website: http://www.nanociencia.imdea.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	498˙750.00
5	UNIVERSITY OF THE WEST OF ENGLAND, BRISTOL UNIVERSITY OF THE WEST OF ENGLAND, BRISTOL Organization address address: Frenchay Campus, Coldharbour Lane city: BRISTOL postcode: BS16 1QY website: www.uwe.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRISTOL)	participant	445˙925.00
6	UNIVERSITY OF BRISTOL UNIVERSITY OF BRISTOL Organization address address: BEACON HOUSE QUEENS ROAD city: BRISTOL postcode: BS8 1QU website: www.bristol.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRISTOL)	participant	407˙056.00
7	ABO AKADEMI ABO AKADEMI Organization address address: DOMKYRKOTORGET 3 city: ABO postcode: 20500 website: http://www.abo.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (ABO)	participant	268˙861.00

Map

Project objective

EVO-NANO aims to create an integrated cross-disciplinary platform for the artificial evolution and assessment of nanoparticle-based drug delivery systems. Nanoparticles (NP) are increasingly being studied in cancer research for their ability to improve diagnosis accuracy and/or deliver tailored treatments directly to tumours. However, their effective biodistribution is still a major limitation. The challenge is to discover how to program collective behaviour of the trillions of NP interacting in a complex tumour environment. Finding effective NP designs that give rise to desired outcome will require a new class of evolutionary algorithms that can simultaneously 1) generate novel NP-based anti-cancer strategies, 2) search over a large space of solutions, and 3) adapt to a wide variety of scenarios. Our novel evolutionary approach will be integrated with PhysiCell (http://physicell.mathcancer.org) and NanoDoc (http://nanodoc.org) simulators that reproduces realistic NP motion and interactions within the tumour environment and with other NP. The most promising NP designs will then be synthesized and tested in vivo and in vitro on breast and colon cancer stem cells using mouse cancer xenografts and microfluidic testbeds featuring cancer microenvironments. To promote translation of the platform from early stage research into a commercialized product for patients, we will work with industrial partner ProChimia Surfaces, organize ‘Industry Open Days’ for potential investors and develop a translation strategy. EVO-NANO is a multidisciplinary project that will create an entirely novel NP design platform for new cancer treatments, capable of autonomously evolving both innovative and adaptive solutions. The proposed platform has the potential to be at the forefront of cancer nanomedicine by enabling much faster development and assessment of new cancer treatments, than is done today. The project will generate concrete tools for the predictive design of nanomedicines that could be applied in other clinical fields.

Deliverables

List of deliverables.
Web site, logo and other mass media presence	Documents, reports	2020-01-14 14:23:48
Data management plan	Open Research Data Pilot	2020-01-14 14:23:51
Technical/scientific review meeting documents for RP1	Documents, reports	2020-01-14 14:23:49
Dissemination and Exploitation Plan at the end of the first Reporting Period (RP1)	Documents, reports	2020-01-14 14:23:14
eCS vascular and CSC strategies	Documents, reports	2020-01-14 14:24:26
Report of the kick-off meeting	Documents, reports	2020-01-14 14:23:50
Initial eCS implementation and testing	Other	2020-01-14 14:23:51
Evolutionary model definition and specifications	Documents, reports	2020-01-14 14:23:49

Take a look to the deliverables list in detail: detailed list of EVO-NANO deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Petra Gener, Sara Montero, Helena Xandri-Monje, Zamira V. DÃaz-Riascos, Diana Rafael, Fernanda Andrade, Francesc MartÃnez-Trucharte, Patricia GonzÃ¡lez, Joaquin Seras-Franzoso, Albert Manzano, Diego Arango, Joan SayÃ³s, Ibane Abasolo, Simo Schwartz Zileutonâ„¢ loaded in polymer micelles effectively reduce breast cancer circulating tumor cells and intratumoral cancer stem cells published pages: 102106, ISSN: 1549-9634, DOI: 10.1016/j.nano.2019.102106	Nanomedicine: Nanotechnology, Biology and Medicine 24	2019-12-16
2019	Richard J. Preen, Larry Bull, Andrew Adamatzky Towards an evolvable cancer treatment simulator published pages: 1-7, ISSN: 0303-2647, DOI: 10.1016/j.biosystems.2019.05.005	Biosystems 182	2019-08-06

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