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NICI SIGNED

Non-Invasive Chemistry Imaging in the whole human body

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

NICI project word cloud

Explore the words cloud of the NICI project. It provides you a very rough idea of what is the project "NICI" about.

biomarkers platform imaging metabolic foundations chemists metabolites resonance discovering co images ambition biochemistry mechanisms foundational validate measuring clinicians technological biology exact scanners 7t interdisciplinary biochemical discriminative discovery adapt gastrointestinal liver stratification largely dynamically biologists invasive patients strategy physicists chemical cancer mapping treatment visible powerful metabolomics morphologic dynamic cultured vision data models lay advancing unite body establishing full unknown predictive shift researching prognostic human vitro magnetic area 3d paradigm chemistry risk mri discriminant functions window breakthroughs acquisition metastasis detect novelty organoids nici organs basis diseases methodology

Project "NICI" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Project website	http://metascan-nici.eu
Total cost	3˙146˙973 €
EC max contribution	3˙146˙973 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-1-2016-2017
Funding Scheme	RIA
Starting year	2018
Duration (year-month-day)	from 2018-06-01 to 2021-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	coordinator	558˙431.00
2	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	610˙307.00
3	IMAGO 7 FONDAZIONE DI RICERCA ONLUS IMAGO 7 FONDAZIONE DI RICERCA ONLUS Organization address address: VIALE DEL TIRRENO 331 city: CALAMBRONE PISA postcode: 56128 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CALAMBRONE PISA)	participant	608˙343.00
4	ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Organization address address: MEIBERGDREEF 15 city: AMSTERDAM postcode: 1105AZ website: www.amc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM)	participant	598˙593.00
5	MR COILS BV MR COILS BV Organization address address: SHIMMINCK 18 city: ZALTBOMMEL postcode: 5301 KR website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ZALTBOMMEL)	participant	497˙066.00
6	NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU Organization address address: HOGSKOLERINGEN 1 city: TRONDHEIM postcode: 7491 website: www.ntnu.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (TRONDHEIM)	participant	100˙177.00
7	GENERAL ELECTRIC DEUTSCHLAND HOLDING GMBH GENERAL ELECTRIC DEUTSCHLAND HOLDING GMBH Organization address address: BLEICHSTRASSE 64-66 city: FRANKFURT AM MAIN postcode: 60313 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (FRANKFURT AM MAIN)	participant	59˙328.00
8	PHILIPS MEDICAL SYSTEMS NEDERLAND BV PHILIPS MEDICAL SYSTEMS NEDERLAND BV Organization address address: VEENPLUIS 6 city: BEST postcode: 5684 PC website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (BEST)	participant	58˙370.00
9	SIEMENS HEALTHCARE LIMITED SIEMENS HEALTHCARE LIMITED Organization address address: FARADAY HOUSE SIR WILLIAM SIEMENS SQUARE city: CAMBERLEY postcode: GU16 8QD website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBERLEY)	participant	56˙355.00

Map

Project objective

The NICI project’s ambition is to lay the foundations of a new area of research: the study of human biology using non-invasive chemistry imaging. For this, NICI aims to unite two areas of research: metabolomics and magnetic resonance imaging (MRI). Metabolomics studies body functions through the measurement of metabolites; MRI, is able to provide 3D images of the body. By advancing MRI so that it can detect metabolic biomarkers and by discovering powerful new MRI-visible biomarkers, a non-invasive technology can be developed for dynamically mapping biochemical processes in the whole human body.

Vision: This new non-invasive technology for imaging biochemical processes in the human body will open a new and effective window for understanding human biology, diseases and their treatment.

Breakthroughs: I. Methodology for the discovery of discriminative biomarkers and II. Technological platform for full body biochemical imaging.

Novelty: Enabling a paradigm shift from morphologic imaging to biochemical understanding.

Foundational: Establishing the basis for a new research area, the study of human biochemistry using non-invasive biochemical imaging.

High-risk: i) The exact mechanisms of diseases are largely unknown and ii) Measuring specific metabolites is challenging.

Interdisciplinary: Bringing together physicists, biologists, chemists and clinicians.

The NICI project will develop a new methodology for the in vitro discovery of discriminant biomarkers using co-cultured 3D organoids as models for human organs. In addition, the project will develop a measurement platform, integrated with 7T MRI scanners and associated data acquisition approaches to adapt these MRI scanners into 3D biochemical imaging systems. NICI will validate the dynamic 3D chemical imaging approach and its predictive and prognostic value by researching a stratification strategy for patients with liver metastasis of gastrointestinal cancer. (This is one out of many possible applications.)

Deliverables

List of deliverables.
NICI organoid culture bank with 90 organoids	Documents, reports	2020-01-21 17:32:15
List of groups and stakeholders for targeted dissemination	Documents, reports	2020-01-21 17:32:15
Data Management Plan	Open Research Data Pilot	2020-01-21 17:32:15
First design on new imaging characteristics	Documents, reports	2020-01-21 17:32:15
Established cross-vendor DICOM standard for chemistry imaging data	Documents, reports	2020-01-21 17:32:15
Report on imaging strategy	Documents, reports	2020-01-21 17:32:15
Safety margin files for using the quintuple body resonator with and without meta-materials	Documents, reports	2020-01-21 17:32:15
NICI website and logo	Documents, reports	2020-01-21 17:32:15

Take a look to the deliverables list in detail: detailed list of NICI deliverables.

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The information about "NICI" are provided by the European Opendata Portal: CORDIS opendata.