Opendata, web and dolomites

ASTHMACRYSTALCLEAR SIGNED

Role of protein crystallization in type 2 immunity and asthma

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ASTHMACRYSTALCLEAR project word cloud

Explore the words cloud of the ASTHMACRYSTALCLEAR project. It provides you a very rough idea of what is the project "ASTHMACRYSTALCLEAR" about.

resistant    alternatives    proteins    patients    murine    ym1    amounts    release    innovative    eosinophils    infection    protein    science    cells    hallmark    antibodies    steroid    understand    chronic    markers    demise    activated    mice    asthma    turn    extracellular    airways    crystal    immunoregulation    frontline    unknown    full    tool    helminth    clinical    alternatively    therapies    physiology    eliminate    hypothesize    rhinosinusitis    macrophages    abundantly    human    active    immunity    integrative    ym2    serves    galectin    eosinophilic    structure    crystallization    inflammation    crystallizing    disease    function    biology    accumulation    slow    sequester    depleting    accompanied    prolong    activation    elution    leyden    view    charcot    immunology    physiological    danger    benefit    chose    harmless    crystalline    made    rare    signal    event    crystals    chitinase    structural    spontaneous    medical    molecular    creation    eosinophil    soluble    combines   

Project "ASTHMACRYSTALCLEAR" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙499˙846 €
 EC max contribution 2˙499˙846 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 2˙499˙846.00

Map

 Project objective

Spontaneous protein crystallization is a rare event in biology. Eosinophilic inflammation such as seen in the airways in asthma, chronic rhinosinusitis and helminth infection is however accompanied by accumulation of large amounts of extracellular Charcot-Leyden crystals. These are made of Galectin-10, a protein of unknown function produced by eosinophils, hallmark cells of type 2 immunity. In mice, eosinophilic inflammation is also accompanied by protein crystal build up, composed of the chitinase-like proteins Ym1 and Ym2, produced by alternatively activated macrophages. Here we challenge the current view that these crystals are just markers of eosinophil demise or macrophages activation. We hypothesize that protein crystallization serves an active role in immunoregulation of type 2 immunity. On the one hand, crystallization might turn a harmless protein into a danger signal. On the other hand, crystallization might sequester and eliminate the physiological function of soluble Galectin-10 and Ym1, or prolong it via slow release elution. For full understanding, we therefore need to understand the function of the proteins in a soluble and crystalline state. Our program at the frontline of immunology, molecular structural biology and clinical science combines innovative tool creation and integrative research to investigate the structure, function, and physiology of galectin-10 and related protein crystals. We chose to study asthma as the crystallizing proteins are abundantly present in human and murine disease. There is still a large medical need for novel therapies that could benefit patients with chronic steroid-resistant disease, and are alternatives to eosinophil-depleting antibodies whose long term effects are unknown.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ASTHMACRYSTALCLEAR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ASTHMACRYSTALCLEAR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

RECON (2019)

Reprogramming Conformation by Fluorination: Exploring New Areas of Chemical Space

Read More  

TroyCAN (2020)

Redefining the esophageal stem cell niche – towards targeting of squamous cell carcinoma

Read More  

DISSECT (2020)

DISSECT: Evidence in International Human Rights Adjudication

Read More