Opendata, web and dolomites

ASTHMACRYSTALCLEAR SIGNED

Role of protein crystallization in type 2 immunity and asthma

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 ASTHMACRYSTALCLEAR project word cloud

Explore the words cloud of the ASTHMACRYSTALCLEAR project. It provides you a very rough idea of what is the project "ASTHMACRYSTALCLEAR" about.

combines    disease    soluble    markers    infection    resistant    crystallizing    physiological    patients    crystalline    clinical    tool    eosinophil    full    frontline    science    therapies    immunoregulation    leyden    chose    sequester    eosinophilic    airways    structural    steroid    mice    human    macrophages    turn    asthma    benefit    elution    chitinase    physiology    abundantly    galectin    structure    murine    active    demise    innovative    crystallization    integrative    release    charcot    spontaneous    ym1    molecular    accompanied    eosinophils    antibodies    inflammation    accumulation    biology    helminth    eliminate    activation    crystal    proteins    crystals    ym2    depleting    serves    chronic    danger    event    understand    view    hypothesize    protein    immunity    unknown    alternatively    amounts    cells    rhinosinusitis    prolong    function    immunology    alternatives    rare    harmless    made    signal    activated    slow    hallmark    creation    medical    extracellular   

Project "ASTHMACRYSTALCLEAR" data sheet

The following table provides information about the project.

Coordinator
VIB VZW 

Organization address
address: RIJVISSCHESTRAAT 120
city: ZWIJNAARDE - GENT
postcode: 9052
website: www.vib.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 2˙499˙846 €
 EC max contribution 2˙499˙846 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    VIB VZW BE (ZWIJNAARDE - GENT) coordinator 2˙499˙846.00

Map

 Project objective

Spontaneous protein crystallization is a rare event in biology. Eosinophilic inflammation such as seen in the airways in asthma, chronic rhinosinusitis and helminth infection is however accompanied by accumulation of large amounts of extracellular Charcot-Leyden crystals. These are made of Galectin-10, a protein of unknown function produced by eosinophils, hallmark cells of type 2 immunity. In mice, eosinophilic inflammation is also accompanied by protein crystal build up, composed of the chitinase-like proteins Ym1 and Ym2, produced by alternatively activated macrophages. Here we challenge the current view that these crystals are just markers of eosinophil demise or macrophages activation. We hypothesize that protein crystallization serves an active role in immunoregulation of type 2 immunity. On the one hand, crystallization might turn a harmless protein into a danger signal. On the other hand, crystallization might sequester and eliminate the physiological function of soluble Galectin-10 and Ym1, or prolong it via slow release elution. For full understanding, we therefore need to understand the function of the proteins in a soluble and crystalline state. Our program at the frontline of immunology, molecular structural biology and clinical science combines innovative tool creation and integrative research to investigate the structure, function, and physiology of galectin-10 and related protein crystals. We chose to study asthma as the crystallizing proteins are abundantly present in human and murine disease. There is still a large medical need for novel therapies that could benefit patients with chronic steroid-resistant disease, and are alternatives to eosinophil-depleting antibodies whose long term effects are unknown.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "ASTHMACRYSTALCLEAR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "ASTHMACRYSTALCLEAR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

HYDROGEN (2019)

HighlY performing proton exchange membrane water electrolysers with reinforceD membRanes fOr efficient hydrogen GENeration

Read More  

REPLAY_DMN (2019)

A theory of global memory systems

Read More  

E-DIRECT (2020)

Evolution of Direct Reciprocity in Complex Environments

Read More