LIGHTUP SIGNED
Turning the cortically blind brain to see: from neural computations to system dynamicsgenerating visual awareness in humans and monkeys
Total Cost €
0EC-Contrib. €
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Project "LIGHTUP" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITA DEGLI STUDI DI TORINO
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Total cost | 1˙994˙212 € |
| EC max contribution | 1˙994˙212 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-08-01 to 2023-07-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITA DEGLI STUDI DI TORINO | IT (TORINO) | coordinator | 1˙067˙288.00 |
| 2 | STICHTING KATHOLIEKE UNIVERSITEIT BRABANT | NL (TILBURG) | participant | 666˙923.00 |
| 3 | THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD | UK (OXFORD) | participant | 260˙000.00 |
Map
Project objective
Visual awareness affords flexibility and experiential richness, and its loss following brain damage has devastating effects. However, patients with blindness following cortical damage may retain visual functions, despite visual awareness is lacking (blindsight). But, how can we translate non-conscious visual abilities into conscious ones after damage to the visual cortex? To place our understanding of visual awareness on firm neurobiological and mechanistic bases, I propose to integrate human and monkey neuroscience. Next, I will translate this wisdom into evidence-based clinical intervention. First, LIGHTUP will apply computational neuroimaging methods at the micro-scale level, estimating population receptive fields in humans and monkeys. This will enable analyzing fMRI signal similar to the way tuning properties are studied in neurophysiology, and to clarify how brain areas translate visual properties into responses associated with awareness. Second, LIGHTUP leverages a behavioural paradigm that can dissociate nonconscious visual abilities from awareness in monkeys, thus offering a refined animal model of visual awareness. Applying behavioural-Dynamic Causal Modelling to combine fMRI and behavioral data, LIGHTUP will build up a Bayesian framework that specifies the directionality of information flow in the interactions across distant brain areas, and their causal role in generating visual awareness. In the third part, I will devise a rehabilitation protocol that combines brain stimulation and visual training to promote the (re)emergence of lost visual awareness. LIGHTUP will exploit non-invasive transcranial magnetic stimulation (TMS) in a novel protocol that enables stimulation of complex cortical circuits and selection of the direction of connectivity that is enhanced. This associative stimulation has been proven to induce Hebbian plasticity, and we have piloted its effects in fostering visual awareness in association with visual restoration training.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Alessia Celeghin, Arianna Bagnis, Matteo Diano, Carlos Andrés Méndez, Tommaso Costa, Marco Tamietto Functional neuroanatomy of blindsight revealed by activation likelihood estimation meta-analysis published pages: 109-118, ISSN: 0028-3932, DOI: 10.1016/j.neuropsychologia.2018.06.007 |
Neuropsychologia 128 | 2020-04-15 |
| 2019 |
James Danckert, Marco Tamietto, Yves Rossetti Definition: Blindsight published pages: 569-570, ISSN: 0010-9452, DOI: 10.1016/j.cortex.2019.01.027 |
Cortex 119 | 2020-04-15 |
| 2019 |
Arianna Bagnis, Alessia Celeghin, Cristina Onesta Mosso, Marco Tamietto Toward an integrative science of social vision in intergroup bias published pages: 318-326, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2019.04.020 |
Neuroscience & Biobehavioral Reviews 102 | 2020-04-15 |
| 2019 |
Loraine Georgy, Bert Jans, Marco Tamietto, Alain Ptito Functional reorganization of population receptive fields in a hemispherectomy patient with blindsight published pages: 198-203, ISSN: 0028-3932, DOI: 10.1016/j.neuropsychologia.2018.06.026 |
Neuropsychologia 128 | 2020-04-15 |
| 2020 |
Elizabeth S. Paul, Shlomi Sher, Marco Tamietto, Piotr Winkielman, Michael T. Mendl Towards a comparative science of emotion: Affect and consciousness in humans and animals published pages: 749-770, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2019.11.014 |
Neuroscience & Biobehavioral Reviews 108 | 2020-04-15 |
| 2019 |
Alessia Celeghin, Valentina Galetto, Marco Tamietto, Marina Zettin Emotion Recognition in Low-Spatial Frequencies Is Partly Preserved following Traumatic Brain Injury published pages: 1-10, ISSN: 2314-6133, DOI: 10.1155/2019/9562935 |
BioMed Research International 2019 | 2020-04-15 |
| 2019 |
Marco Tamietto, Robert W. Kentridge Standing on the shoulders of a giant published pages: 2-5, ISSN: 0028-3932, DOI: 10.1016/j.neuropsychologia.2019.04.020 |
Neuropsychologia 128 | 2020-04-15 |
| 2020 |
Elisabetta Palagi, Alessia Celeghin, Marco Tamietto, Piotr Winkielman, Ivan Norscia The neuroethology of spontaneous mimicry and emotional contagion in human and non-human animals published pages: 149-165, ISSN: 0149-7634, DOI: 10.1016/j.neubiorev.2020.01.020 |
Neuroscience & Biobehavioral Reviews 111 | 2020-04-15 |
| 2018 |
Beatrice de Gelder, Rebecca Watson, Minye Zhan, Matteo Diano, Marco Tamietto, Maarten J. Vaessen Classical paintings may trigger pain and pleasure in the gendered brain published pages: 171-180, ISSN: 0010-9452, DOI: 10.1016/j.cortex.2018.09.011 |
Cortex 109 | 2020-04-15 |
| 2019 |
Matthias Michel, Diane Beck, Ned Block, Hal Blumenfeld, Richard Brown, David Carmel, Marisa Carrasco, Mazviita Chirimuuta, Marvin Chun, Axel Cleeremans, Stanislas Dehaene, Stephen M. Fleming, Chris Frith, Patrick Haggard, Biyu J. He, Cecilia Heyes, Melvyn A. Goodale, Liz Irvine, Mitsuo Kawato, Robert Kentridge, Jean-Remi King, Robert T. Knight, Sid Kouider, Victor Lamme, Dominique Lamy, Hakwan Lau Opportunities and challenges for a maturing science of consciousness published pages: 104-107, ISSN: 2397-3374, DOI: 10.1038/s41562-019-0531-8 |
Nature Human Behaviour 3/2 | 2020-04-15 |
| 2018 |
Hisao Nishijo, Robert Rafal, Marco Tamietto Editorial: Limbic-Brainstem Roles in Perception, Cognition, Emotion, and Behavior published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2018.00395 |
Frontiers in Neuroscience 12 | 2020-03-05 |
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