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BSLchlamy SIGNED

Understanding the essential function of the conserved plant-specific protein phosphatase family BSL

Total Cost €

EC-Contrib. €

Partnership

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BSLchlamy project word cloud

Explore the words cloud of the BSLchlamy project. It provides you a very rough idea of what is the project "BSLchlamy" about.

mutant tool conservation homolog regulation size interactome phosphatase family biochemical gene single universally screen proteomic contrast mutation lethality root effectors albeit return broad functions combination genetic conserved land arabidopsis translate isolation protein genes molecular reinhardtii embryonic meristem celular rapid mitosis bsl variety shows completely functional consistent progression immunoprecipitation knock cell substrates mechanistic phosphoproteomic hampered green microscopic switching bsl1 seriously suggests community unknown division redundancy viridiplantae mitotic characterization celled first model conditional coupled mutants biology multicellular look basis alga phenotype perform evolutionarily cycle algae downstream plants plays chlamydomonas plant temperature

Project "BSLchlamy" data sheet

The following table provides information about the project.

Coordinator	TECHNISCHE UNIVERSITAET MUENCHEN Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 website: www.tu-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	257˙860 €
EC max contribution	257˙860 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-GF
Starting year	2018
Duration (year-month-day)	from 2018-12-11 to 2022-01-02

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	TECHNISCHE UNIVERSITAET MUENCHEN TECHNISCHE UNIVERSITAET MUENCHEN Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 website: www.tu-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	coordinator	257˙860.00
2	CARNEGIE INSTITUTION OF WASHINGTON CARNEGIE INSTITUTION OF WASHINGTON Organization address address: P STREET NW 1530 city: WASHINGTON DC postcode: 20005 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (WASHINGTON DC)	partner	0.00

Map

Project objective

The protein phosphatase family BSL is highly conserved and universally present in all green plants, from single-celled algae to multicellular land plants. Genetic evidence shows that it plays an essential, albeit completely unknown, role in plant cell biology. The model plant Arabidopsis has four BSL genes, but genetic redundancy coupled with embryonic lethality of mutants has seriously hampered functional studies of the family. In contrast, the green alga Chlamydomonas reinhardtii has only a single BSL homolog and the recent isolation of a temperature-conditional mutation (bsl1-1) in this gene generated a unique tool for rapid switching of BSL activity to study its molecular/celular functions. Detailed analysis of the bsl1-1 mutant identified a role for BSl1 in cell division in Chlamydomonas, specifically in mitotic progression. This phenotype is also consistent with the reduced meristem size observed in BSL knock-down in Arabidopsis and suggests an evolutionarily conserved role for the BSL phosphatase in cell cycle regulation. In the proposed project I will first perform a comprehensive proteomic/biochemical analysis of BSL1 in Chlamydomonas to identify the mechanistic basis for its key role in mitosis. This analysis with include (i) a phosphoproteomic screen to look for substrates and downstream effectors of the BSL1 phosphatase, and (ii) a characterization the BSL1 interactome using a variety of immunoprecipitation-based methods. I will then, during the return phase, translate the findings from Chlamydomonas into Arabidopsis by studying the role of BSL during root meristem development using a combination of microscopic and genetic approaches. Given the conservation of the BSL family throughout the viridiplantae, the results from this study are likely to have a broad impact on the plant biology research community.

Publications

List of publications.
year	authors and title	journal	last update
2019	Frej Tulin Mating and Tetrad Dissection in Chlamydomonas published pages: , ISSN: 2331-8325, DOI: 10.21769/bioprotoc.3207	BIO-PROTOCOL 9/7	2020-01-21

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