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DelNAM SIGNED

Strengthening the Research Area of Delivery of Nucleic acid mimics (NAMS) into bacteria to fight the antibiotic crisis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

DelNAM project word cloud

Explore the words cloud of the DelNAM project. It provides you a very rough idea of what is the project "DelNAM" about.

regional antibiotic acid complementary of integrates extensive gene line fluids consolidated nanodelivery acids scope denmark university engineering synthetic synthesis nanotechnology porto behavior molecular structural microbiology bioprocess crisis widening expertise laboratory odense ughent 2016 2017 feup southern global outstanding gaps decisive obtain health sdu delnam invention leader biological national bacteria breakthroughs chemistry internationally nanomedicines strategies excellence fight nams countries strategic area synergies networking therapy nucleic guidelines economy twinning commercialization faculty native mimics deficiencies drugs scientific belgium ghent counterparts

Project "DelNAM" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDADE DO PORTO Organization address address: PRACA GOMES TEIXEIRA city: PORTO postcode: 4099 002 website: http://www.up.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Project website	http://www.delnam.com/
Total cost	960˙853 €
EC max contribution	960˙853 € (100%)
Programme	1. H2020-EU.4.b. (Twinning of research institutions)
Code Call	H2020-WIDESPREAD-05-2017-Twinning
Funding Scheme	CSA
Starting year	2018
Duration (year-month-day)	from 2018-08-01 to 2021-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDADE DO PORTO UNIVERSIDADE DO PORTO Organization address address: PRACA GOMES TEIXEIRA city: PORTO postcode: 4099 002 website: http://www.up.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (PORTO)	coordinator	475˙978.00
2	SYDDANSK UNIVERSITET SYDDANSK UNIVERSITET Organization address address: CAMPUSVEJ 55 city: ODENSE M postcode: 5230 website: www.sdu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (ODENSE M)	participant	246˙125.00
3	UNIVERSITEIT GENT UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 website: http://www.ugent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GENT)	participant	238˙750.00

Map

Project objective

DelNAM aims at Strengthening the Research Area of Delivery of Nucleic Acid Mimics (NAMS) into bacteria to fight the antibiotic crisis. This will be achieved by twinning the Faculty of Engineering of the University of Porto (FEUP) with outstanding EU institutions with high expertise in the areas of NAMs development and nanodelivery strategies. DelNAM will allow the development of a consolidated strategic research approach and a set of guidelines for exploitation and commercialization of the results that will have a strong regional, national and European impact. The proposal integrates synergies in complementary fields of research that include nanotechnology, synthetic chemistry, microbiology and bioprocess modelling, aiming to obtain scientific breakthroughs that can improve the global health and economy.

The objectives of this proposal are in line with the specific challenge and scope of the topic H2020-WIDESPREAD-2016-2017 of the Twinning call, addressing networking gaps and deficiencies between the research institutions of the Widening countries and internationally-leading counterparts at EU level. This challenge is addressed by twinning FEUP with 2 leading EU research institutions: University of Southern Denmark (SDU), in Odense, Denmark, a global leader in the development and invention of novel NAMs for gene therapy. They contribute with their extensive experience on the synthesis, structural studies and molecular modelling of NAMs; Ghent University (UGhent), in Belgium, an internationally-recognized laboratory for its excellence in the field of nanomedicines for the delivery of drugs and, in particular, nucleic acids. They provide decisive expertise on the design of delivery systems for nucleic acids and their behavior in native biological fluids.

Deliverables

List of deliverables.
Website and social media sites	Websites, patent fillings, videos etc.	2020-03-09 16:07:20
Annual report on high impact publications	Documents, reports	2020-03-09 16:07:19

Take a look to the deliverables list in detail: detailed list of DelNAM deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2016	SÃlvia Fontenete, Daniel Carvalho, Nuno GuimarÃ£es, Pedro Madureira, CÃ©u Figueiredo, Jesper Wengel, Nuno Filipe Azevedo Application of locked nucleic acid-based probes in fluorescence in situ hybridization published pages: 5897-5906, ISSN: 0175-7598, DOI: 10.1007/s00253-016-7429-4	Applied Microbiology and Biotechnology 100/13	2019-10-08
2017	Rita S. Santos, George R. Dakwar, Elisa Zagato, Toon Brans, CÃ©u Figueiredo, Koen Raemdonck, Nuno F. Azevedo, Stefaan C. De Smedt, Kevin Braeckmans Intracellular delivery of oligonucleotides in Helicobacter pylori by fusogenic liposomes in the presence of gastric mucus published pages: 1-12, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2017.05.029	Biomaterials 138	2019-10-08
2017	Andreia S. Azevedo, Carina Almeida, Luciana C. Gomes, Carla Ferreira, Filipe J. MergulhÃ£o, LuÃs F. Melo, Nuno F. Azevedo An in vitro model of catheter-associated urinary tract infections to investigate the role of uncommon bacteria on the Escherichia coli microbial consortium published pages: 64-69, ISSN: 1369-703X, DOI: 10.1016/j.bej.2016.11.013	Biochemical Engineering Journal 118	2019-10-08
2015	Rita S Santos, George R Dakwar, Ranhua Xiong, Katrien Forier, Katrien Remaut, Stephan Stremersch, Nuno GuimarÃ£es, SÃlvia Fontenete, Jesper Wengel, Marina Leite, CÃ©u Figueiredo, Stefaan C De Smedt, Kevin Braeckmans, Nuno F Azevedo Effect of Native Gastric Mucus on in vivo Hybridization Therapies Directed at Helicobacter pylori published pages: e269, ISSN: 2162-2531, DOI: 10.1038/mtna.2015.46	Molecular Therapy - Nucleic Acids 4	2019-10-08
2016	SÃlvia Fontenete, Marina Leite, Davie Cappoen, Rita Santos, Chris Van Ginneken, CÃ©u Figueiredo, Jesper Wengel, Paul Cos, Nuno Filipe Azevedo Fluorescence In Vivo Hybridization (FIVH) for Detection of Helicobacter pylori Infection in a C57BL/6 Mouse Model published pages: e0148353, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0148353	PLOS ONE 11/2	2019-10-08
2016	Andreia S. Azevedo, Carina Almeida, Bruno Pereira, LuÃs F. Melo, Nuno F. Azevedo Impact of Delftia tsuruhatensis and Achromobacter xylosoxidans on Escherichia coli dual-species biofilms treated with antibiotic agents published pages: 227-241, ISSN: 0892-7014, DOI: 10.1080/08927014.2015.1124096	Biofouling 32/3	2019-10-08
2016	SÃlvia Fontenete, Nuno GuimarÃ£es, Jesper Wengel, Nuno Filipe Azevedo Prediction of melting temperatures in fluorescence in situ hybridization (FISH) procedures using thermodynamic models published pages: 1-12, ISSN: 0738-8551, DOI: 10.3109/07388551.2014.993589	Critical Reviews in Biotechnology	2019-10-08
2015	Fontenete Silvia, Barros Joana, Madureira Pedro, Figueiredo CÃ©u, Wengel Jesper, Azevedo Nuno Filipe Mismatch discrimination in fluorescent in situ hybridization using different types of nucleic acids published pages: 3961-3969, ISSN: 0175-7598, DOI: 10.1007/s00253-015-6389-4	Applied Microbiology and Biotechnology 99/9	2019-10-08
2016	Luzia Mendes, Rui Rocha, Andreia Sofia Azevedo, Catarina Ferreira, Mariana Henriques, Miguel GonÃ§alves Pinto, Nuno Filipe Azevedo Novel strategy to detect and locate periodontal pathogens: The PNA-FISH technique published pages: 185-191, ISSN: 0944-5013, DOI: 10.1016/j.micres.2016.07.002	Microbiological Research 192	2019-10-08
2015	Andreia S. Azevedo, Carina Almeida, Bruno Pereira, Pedro Madureira, Jesper Wengel, Nuno F. Azevedo Detection and discrimination of biofilm populations using locked nucleic acid/2â€²-O-methyl-RNA fluorescence in situ hybridization (LNA/2â€²OMe-FISH) published pages: 64-73, ISSN: 1369-703X, DOI: 10.1016/j.bej.2015.04.024	Biochemical Engineering Journal 104	2019-10-08
2016	Rui Rocha, Rita S. Santos, Pedro Madureira, Carina Almeida, Nuno F. Azevedo Optimization of peptide nucleic acid fluorescence in situ hybridization (PNA-FISH) for the detection of bacteria: The effect of pH, dextran sulfate and probe concentration published pages: 1-7, ISSN: 0168-1656, DOI: 10.1016/j.jbiotec.2016.03.047	Journal of Biotechnology 226	2019-10-08
2017	Susana P. Lopes, Daniel T. Carvalho, Maria O. Pereira, Nuno F. Azevedo Discriminating typical and atypical cystic fibrosis-related bacteria by multiplex PNA-FISH published pages: 355-367, ISSN: 0006-3592, DOI: 10.1002/bit.26085	Biotechnology and Bioengineering 114/2	2019-10-08
2015	SÃlvia Fontenete, Marina Leite, Nuno GuimarÃ£es, Pedro Madureira, Rui Manuel Ferreira, CÃ©u Figueiredo, Jesper Wengel, Nuno Filipe Azevedo Towards Fluorescence In Vivo Hybridization (FIVH) Detection of H. pylori in Gastric Mucosa Using Advanced LNA Probes published pages: e0125494, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0125494	PLOS ONE 10/4	2019-10-08

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