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One4Two SIGNED

All-in-one genetic test for fast and accurate diagnosis of the causes of infertility

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

One4Two project word cloud

Explore the words cloud of the One4Two project. It provides you a very rough idea of what is the project "One4Two" about.

reduce impacts kronosdna effectiveness laboratories gynecologist probability infertility lack report provides diagnostic gynecologists million time business couple prescribed batteries negatively affordable 25 adding commercialization certifications simplify generation service panel diagnosis price blood days strategy pricing first consolidating complete fragmented couples parent cumbersome one4two ground cover proprietary pregnancy tests fertility suitable 35 distress treat preventing origin prepare model disorder handful investigation caused reagents therapies upscaling scores dna desire mutations times infertile uncomprehensive lab diseases fulfilling sequencing optimized workload citizens transmission inherited complicates protocol linked psychological causes reproductive genetic software poised marketing

Project "One4Two" data sheet

The following table provides information about the project.

Coordinator	KRONOSDNA S.R.L. Organization address address: VIA LOGGIA DEI PISANI 25 city: NAPOLI postcode: 80133 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	https://kronosdna.blog/
Total cost	71˙429 €
EC max contribution	50˙000 € (70%)
Programme	1. H2020-EU.3. (PRIORITY 'Societal challenges) 2. H2020-EU.2.3. (INDUSTRIAL LEADERSHIP - Innovation In SMEs) 3. H2020-EU.2.1. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies)
Code Call	H2020-SMEInst-2018-2020-1
Funding Scheme	SME-1
Starting year	2019
Duration (year-month-day)	from 2019-02-01 to 2019-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KRONOSDNA S.R.L. KRONOSDNA S.R.L. Organization address address: VIA LOGGIA DEI PISANI 25 city: NAPOLI postcode: 80133 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (NAPOLI)	coordinator	50˙000.00

Map

Project objective

Infertility is a disorder of the reproductive system which affects 25 million citizens in Europe, preventing them from fulfilling their desire to become a parent. To identify its causes, genetic testing is prescribed to around 35% of the couples under diagnosis, since several factors related to infertility have a genetic origin. However, the effectiveness of infertility genetic analysis and the whole diagnosis process are affected by several issues: an uncomprehensive approach to fertility genetic test, with just a handful of genetic diseases being investigated, each through a dedicated test; a fragmented and cumbersome genetic investigation process that negatively impacts on the couple, adding to the psychological distress caused by infertility, with several batteries of tests often in different laboratories, long diagnosis times and high costs; the lack of a specific genetic testing protocol and diagnosis report for infertility, which increases the workload for laboratories and complicates the diagnosis by gynecologists. KronosDNA has developed One4Two, the first integrated system that provides a comprehensive diagnostic service for the infertile couple, able to cover the whole diagnostic path from lab analysis (through a panel of reagents to analyse DNA through Next Generation Sequencing) to the diagnostic report (by means of a proprietary analysis software). One4Two, with just one blood sample, in 5 days and at an affordable price, provides a complete report on the mutations linked to infertility, probability scores for the transmission of inherited diseases, and the most suitable ART therapies to treat infertility. This is poised to reduce analysis workload, simplify diagnosis by the gynecologist and reduce time to pregnancy. During Phase 1 project, the system will be optimized with end-users to prepare the ground for the required certifications, upscaling and commercialization, by also consolidating the business model, the marketing strategy and the pricing.

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The information about "ONE4TWO" are provided by the European Opendata Portal: CORDIS opendata.

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